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Chemical Science (IF: 9.556)
1. Enantioselective carbene insertion into the N–H bond of benzophenone imine
Chem. Sci., 2019, Advance Article
Researchers from Sichuan University here present the efficient enantioselective insertion of α-diazoesters into the N–H bond of N-sp2-hybridized benzophenone imine using Rh2(esp)2 and chiral quanidine cooperative catalysis, obtaining substituted α-amino esters in high yields with good enantioselectivities.
2. Nickel-catalyzed hydroalkylation and hydroalkenylation of 1,3-dienes with hydrazones
Chem. Sci., 2019, Advance Article
Researchers from Nankai University have reported a protocol for nickel-catalyzed hydroalkylation of dienes with hydrazones, which serve as equivalents of alkyl carbon nucleophiles. In addition, they demonstrate a protocol for hydroalkenylation of dienes with α,β-unsaturated hydrazones, providing a new method for the synthesis of 1,4-dienes.
Organic Chemistry Frontiers (IF: 5.076)
1. Asymmetric domino 1,6-addition/annulation reaction of 3-cyano-4-alkenyl-2H-chromen-2-ones with isatin-derived MBH carbonates: enantioselective synthesis of 3,3'-cyclopentenylspirooxindoles bearing 2H-chromen-2-ones
Org. Chem. Front., 2019, 6, 3342-3347
An asymmetric domino 1,6-addition/annulation reaction of 3-cyano-4-alkenyl-2H-chromen-2-ones with isatin-derived MBH carbonates was achieved. With this developed protocol, a series of 3,3′-cyclopentenylspirooxindoles bearing 2H-chromen-2-ones were obtained in moderate to excellent yields with good to excellent diastereo- and enantioselectivities (>20 : 1 dr, up to 97 : 3 er).
2. Highly convergent modular access to poly-carbon substituted cyclopropanes via Cu(I)-catalyzed three-component cyclopropene carboallylation
Org. Chem. Front., 2019, 6, 3387-3391
We report herein the first example of conjunctive C–C cross-coupling of cyclopropenes enabled by a Cu-catalyzed three-component reaction of organoboron, cyclopropene and allylic bromide, which features a modular, stereoselective assembly of poly-carbon substituted cyclopropanes. Preliminary studies showed that the reaction can be extended to benzylation and made enantioselective with C2-symmetrical bisphosphine ligands.
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