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Prof. Chi-Ming CHE, Zhou Guangzhao Professor in Natural Sciences, Chair Professor of Department of Chemistry, The University of Hong Kong. Prof. Che [H-index: 128] obtained his Ph.D. from The University of Hong Kong in 1982. He joined the Department of Chemistry of The University of Hong Kong in 1983 and is presently the Zhou Guangzhao Professor in Natural Sciences. Prof. Che is an Academician of the Chinese Academy of Sciences (1995), International Member (Foreign Associate) of the US National Academy of Sciences (2013) and Fellow of the World Academy of Sciences (2007). His honors include First Class Prize of the State Natural Science Award of China (2006), the TWAS Prize in Chemistry (2006), Seaborg Lectureship of the University of California at Berkeley (2007), Julia S. and Edward C. Lee Lectureship at University of Chicago (2008), Centenary Prize of Royal Society of Chemistry (2013), Davison Lectureship at Massachusetts Institute of Technology (2013), Huang Yao-Zeng Organometallic Chemistry Award of the Chinese Chemical Society–Lifetime Achievement Award (2016), Ryoji Noyori ACES Award (2016), Peiyang Lecture at Tianjin University (2018), Nankai Centenary Lecture at Nankai University (2019), Luigi Sacconi Medal (2020), Silver Bauhinia Star of the HKSAR (2021).Prof. Che’s research interests include basic and translational coordination chemistry; iron catalysis; metal-catalyzed oxidative alkene and alkane functionalization; reactive metal-ligand multiple bonded complexes; photochemistry and excited state dynamics of transition metal complexes; phosphorescent metal emitters and metal-TADF emitters; chemical biology of anti-cancer metal medicines and tradition Chinese medicines. Over the years, Prof. Che has published over 1,000 papers, with citation over 63,900 times (excluding self-citation). 

Gold is a precious metal with higher earth abundance than iridium. The large spin-orbit coupling constant and relativistic effect of gold, as well as the strong gold-ligand bond, make gold complexes have practical application value as photofunctional/luminescent molecular materials and organic synthesis catalysts. Gold(I) complexes are coordinatively unsaturated and self-assemble to provide multinuclear systems with interesting structures and molecular topologies.Gold(III) complexes are electrophilic at the metal site and are reduced to give Au(I)/Au(0) species with simultaneous ligand release under biological conditions. Therefore, the development of gold chemistry depends on the design and selection of ligands.

In this lecture, the basis and impact of gold-gold interaction in the supramolecular assembly and electronic excited states of gold(I) complexes are discussed. Such gold-gold interaction generates metal-metal bonded excited states capable of activating C−X and C−H bonds of organic substrates in the inner coordination sphere. The long-lived, emitting triplet excited states of gold(III) complexes have been exploited for photoredox catalysis and energy down conversion OLEDs. Through judicious design of ligands, we developed extremely stable gold(I) and gold(III) thermally activated delayed fluorescence (TADF) emitters with high radiative decay rate constants over 106 s−1 and emission quantum yields of up to 0.94/0.89 in solutions/films.OLEDs fabricated with these gold TADF emitters exhibit up to 25.0% EQE and long operating lifetime at practical luminance, marking a major advance in the practicality of gold OLEDs.

Anisotropic structural scaffolds and reactivity of gold(III) complexes offer new opportunities for new anticancer therapies against advanced metastatic cancer. Gold(III) porphyrins and pincer gold(III)-NHC carbene complexes exhibit potent in vivo anti-tumor activity in multiple mouse models of human cancer xenografts and metastasis. By using multi-omics validated by chemical biology methods, these anticancer gold complexes have been shown to bind oncogenic proteins with high affinity through non-covalent interactions. Due to the electrophilic nature of gold(III), the periphery of the gold(III) porphyrin scaffold is activated, leading to the formation of covalent adducts with protein thiols, representing a new bio-molecular interaction for anticancer applications.

Jianmei Lu, Professor, Soochow University, former Vice President of Soochow University (2006–2020). She is currently the chairmen of Suzhou Association for Science and Technology. She was elected as Foreign Full Member (Academician) of the Russian Academy of Engineering, fellow of the Royal Society of Chemistry (RSC), fellow of Chinese Chemical Society and fellow of Chinese Chemical Engineering Society.

Since 1980s, Professor Lu has concentrated on the development of flexible materials for selective adsorption and separation of chemical pollutants and proposed a "through-type" research mode from fundamental research to industrial applications. She won the National Technology Invention Award of China (Rank 1) in 2019 and 2014, respectively, National Science and Technology Progress Award of China in 2013, the Scientific and Technological Progress Award from Ho Leung Ho Lee Foundation in 2020 and RSC Horizon Prize with Professor B.K Sharpless in 2021.

She was awarded 206 invention patents, including 43 registered in US. Among these, more than 40 patents had been either licensed or commercialized. Lu has presided more than 60 science and technology projects, including 16 national key projects, 16 provincial and ministerial projects, and 32 industrialization projects. She has published more than 500 papers as corresponding authors in SCI-indexed journals including Nat. Commun., J. Am. Chem. Soc., Adv. Mater. and Angew. Chem. Int. Ed. 

Adsorption and separation are the most important chemical engineering processes, which have been widely applied in the environmental treatment and remediation. The vital mean of selective and efficient adsorption and separation is the design and construction of adsorption and separation materials. In the past few decades, my research group have been focusing on the design and application of flexible adsorption materials for selective adsorption and separation process. In this report, I will briefly discuss some of our related progress in recent years, including 1) design of flexible polysulfate adsorption materials and study on their adsorption behavior and mechanism towards polar aprotic small organics, 2) design of flexible polyacrylate adsorbents and study on their adsorption behavior and mechanism towards ultra-low concentration organic pollutants, 3) design of flexible micellar adsorption materials and study on its adsorption-degradation behavior towards organic pollutants. Besides, our commercialized cases from lab to market will be presented.

Dr. Yong-Qiang Tu is currently a professor at Lanzhou University and Shanghai Jiao Tong University, China. He graduated in 1982 at Lanzhou University, and received his Master and Ph.D in 1985 and 1989 in the field of organic chemistry at Lanzhou University under the supervision of Prof. Wen-Kui Huang and Prof. Yao-Zu Chen. During 1993–1995, he worked as a postdoctoral fellow with Prof. William Kitching at the University of Queensland, Australia. Then he worked as a visiting professor at Bielefeld University, Germany. He was appointed as a full Professor at Lanzhou University in 1995, and as the director of the State Key Laboratory of Applied Organic Chemistry in 2001. In 2009, he was elected as the academician of the Chinese Academy of Sciences. His research interests include the total synthesis of natural products with important biological activities, and the design, synthesis and application of chiral azaspirocyclic ligands and catalysts in the development of asymmetric catalytic methodology.

The design, synthesis, and application of chiral ligands and catalysts have always been one of the pivotal issues in synthetic chemistry.  In context with our interest in asymmetric catalysis, we recently discovered a series of chiral N-heterospirocycle-based ligands and catalysts, and explored their applications in asymmetric catalytic reactions such as Michael addition, Robinson annulation, bisalkylation, and tandem Mannich/acylation/Wittig olefination. Significantly, the development of these enantioselective catalytic methodologies has enabled the effective total synthesis of biologically active natural products and drug molecules such as galanthamine, codeine, and morphine. Herein we will present our recent progress in the studies of N-heterospirocycle-based catalysts, and their catalytic reactions and synthetic applications. 

Prof. Dan Wang obtained his Ph.D. from Yamanashi University in Japan in 2001. He conducted his post-doctoral research at Kochi University, Research Institute of Innovative Technology for the Earth and Kyoto University, successively. He was awarded by Hundred Talent Program of the CAS, and served as a professor at the Institute of Process Engineering, CAS in 2004. In past years, he mainly focused on the synthetic chemistry on multifunctional structural systems, including design and synthesis of the Hollow Multishelled Structure (HoMS), doping and complex of the 2D carbon materials, and their applications for multicomponent efficient electrodes. He was supported by the National Science Fund for Distinguished Young Scholars in 2013; selected as the Young and Middle-aged Leading Scientists, Engineers and Innovators, Ministry of Science and Technology of the People's Republic of China in 2014; the Young and Middle-aged Leading Scientists, Engineers and Innovators, "Ten thousand plan"-National high level talents special support plan in 2016. He is also the Highly Cited Researcher (Thomson Reuters) in 2018–2022.  

The multifunctional structural system provides an important material basis for human survival and development. For example, the complex hollow and multi-shelled cell constitutes a colorful biological world and realizes the effective circulation of matter and energy in nature. The Hollow Multishelled Structure (HoMS), an "artificial cell structure" with adjustable shells and interlayer environment, is a unique multifunctional structure system, which provides the structural foundation for the multifunction of materials.

Accurate synthesis of unique and novel HoMS is a great challenge in synthetic chemistry! In this study, we established a new universal controllable synthesis method of HoMS: the “Sequential Templating Approach” (STA), which revealed the physical nature of HoMS as the macroscopic expression of concentration waves, and realized its precise synthesis. The unique temporal-spatial ordering characteristic of HoMS was discovered, which extended its application field. The synergistic regulation of effective surface and material transfer of HoMS was revealed, and the creation of efficient multifunctional HoMS-based materials was realized.

Xiaoming Feng is the Chinese Academy of Sciences Academician, the Vice President of the Chinese Chemical Society and the Fellow of the Royal Society of Chemistry, UK. He received his B.S. (1985) and M.S. degrees (1988) from Lanzhou University. In 1996, he received his Ph.D. degree from the Institute of Chemistry, CAS. He did postdoctoral research at Colorado State University (1998–1999). In 2000, he joined Sichuan University as a full professor. Feng dedicated himself into the design of chiral catalysts, development of new synthetic methods and synthesis of bioactive compounds. At present, he has published more than five hundreds papers, as well as obtained seven Chinese invention patents and one American invention patent. He also achieved many honors and awards, including the Second Prize of State Natural Science Award (2012), the First Prize of Natural Science of Ministry of Education (2009 and 2019), the Physical Science Prize of Future Science Prize (2018), the National Innovation and Competition Medal of China (2020), the Tan Kah Kee Science Award (2020), the Ho Leung Ho Lee Foundation Prize for Scientific and Technological Progress (2019), the Outstanding Teaching Award (2019), the Chemistry Contribution Award of Chinese Chemical Society-China Petroleum and Chemical Corporation (2021), the Chiral Chemistry Award of CCS (2016), the Huang Yaozeng Metal Organic Chemistry Award of CCS (2018), the Science and Technology Outstanding Contribution Award of Sichuan (2020), the Outstanding Talent Award of Sichuan (2019), the National Outstanding Professional and Technical Talent (2021).

Diazo compounds are an important type of synthon in organic synthesis. They have been widely used in various organic reactions since first synthesized in 1880s. In recent years, our group has done some innovative and systematic studies in this field by designing new chiral catalysts, new diazo compounds and developing new strategies based on the reaction mechanism. A series of highly efficient and enantioselective transformations of α-diazo esters and α-diazo pyrazoleamides were developed by using chiral N,Nʹ-dioxide-metal complexes, including asymmetric Roskamp-Feng reaction, homologation, cyclopropanation, formal C−H insertion reaction as well as several rearrangement reactions. The reaction mechanisms were also elucidated combined with the theoretical calculation, providing a clue for the design of new asymmetric catalytic reactions of α-diazo carbonyl compounds.

Yang Tian received her PhD degree from Tokyo Institute of Technology and was a postdoctoral researcher at the University of Tokyo. She is currently a distinguished professor at East China Normal University. She is interested in instruments development, biomolecular interfacial design and biosensing for understanding brain events. She also focuses on developing probes for imaging and biosensing in the living brain of freely moving animals. She was a National Distinguished Youth Scholar from NSFC in 2013.

Our group focuses on developing new devices and analytical methods for real-time tracking of chemical and electrical signals simultaneously in the brain of free-moving animals. Systematic and in-depth research has been carried out on breaking the key bottleneck of real-time monitoring and quantification of from reactive oxygen species and oxidative stress-related species in physiological and pathological processes with high selectivity, high accuracy, long-term stability, and designing new devices for brain imaging with high temporal resolution. Firstly, the synergistic strategy based on molecular recognition followed electrochemical recognition was first proposed, and the novel approaches for highly selective determination of oxidative stress-related species were established. By combining electrochemical signal recognition with specific chemical reactions, dual recognition strategies were first established to remarkably enhance the detection selectivity in the complicated brain systems. Secondly, Au−C≡C bond was discovered to demonstrate the highest stability under thiol-rich biological conditions and the best electrochemical performance compared with Au−S and Au−Se bonds. Furthermore, a more reliable sensing platform with long-term stability and anti-biofouling was constructed through rationally integrating highly stable graphene-layered molecular interface, remarkably elongating the time dimension for real-time tracking of the dynamic changes in free-moving animals up from several hours to a record-long 60 days. In addition, a SERS optophysiological probe was created for real-time mapping and recording of chemical and electrical signals without cross-talk in the live brain. Moreover, it was the first time that a Raman fiber photometry was built up for real-time tracking and simultaneous quantitation of multiple molecules in mitochondrial across the brain of free-moving animals. Meanwhile, a highly selective non-metallic Raman probe was created through triple-recognition strategies of chemical reaction, charge transfer, and characteristic fingerprint peaks, for monitoring and quantifying of local mitochondrial O2•−, Ca2+ and pH in six brain regions upon hypoxia. It was discovered that hypoxia-induced O2•− burst was regulated by ASIC1a, leading to mitochondrial Ca2+ overload and acidification.