芝加哥大学Zhou Lab正在寻找对用化学生物学和蛋白/抗体工程方法进行靶向免疫疗法开发有强烈兴趣的博士后研究员。我们专注于化学和生物学的交叉领域，重点研究肿瘤微环境中细胞表面的复杂行为。这是一个为寻求在蛋白/抗体工程和免疫疗法领域做出重大贡献的博士毕业生提供的绝佳机会。在此职位上，你将有机会在芝加哥大学的辐射与细胞肿瘤学系和化学系中与Dr. Zhou紧密合作。Dr. Zhou在肽化学、化学生物学、蛋白/抗体/细胞工程和免疫疗法方面有丰富的经验。Zhou Lab也是芝加哥大学综合癌症中心的成员，为学生博后提供了更多的合作研究和职业发展机会。更多信息，请访问以下链接:
https://voices.uchicago.edu/jzhoulab/research-2/
https://biologicalsciences.uchicago.edu/faculty/jie-zhou
https://chemistry.uchicago.edu/faculty/jie-zhou
该博后将主要参与以下研究方向：
1）探索细胞膜上新的化学和生物机制，这些机制与病理表型有关。
2）利用这些新发现推进下一代免疫治疗的发展。
3）利用小分子和生物技术深入了解疾病，并推动创新治疗方法的研发。
该博后将使用包括合成化学、蛋白质组学、功能基因组学和蛋白/抗体/细胞工程在内的多种技术。同时，你还会运用如噬菌体/酵母/细胞/病毒展示等组合选择技术，并结合下一代测序和生物信息学来深化生物研究。
我们希望你能够有效开展和管理多个项目，保持清晰完整的研究记录。你能够在团队会议和外部学术研讨会中展示你的研究成果。我们希望你既能独立工作，又能跟他人有效作。我们希望你有化学、化学生物学或生物化学相关的博士学位。有机化学背景或分子生物 实验经验，如克隆、蛋白质表达和纯化，将是一个加分项。对基本的免疫学概念有所了解，熟悉组合选择技术、下一代测序和生物信息学将非常受欢迎。
薪酬按照NIH NRSA津贴标准。关于芝加哥大学生物科学部博士后的福利和其他信息，请访问此链接。芝加哥大学是一个提供平等机会给残疾人和退伍军人的雇主。
有意者请将简历以及2-3位推荐人的信息(姓名，机构，邮箱，等)发送至邮箱：jiezhou6@uchicago.edu。我们期待你的加入，希望你能成为我们团队的一员。
Title: Postdoc in Chemical Biology and Protein/Antibody Engineering
Biological Sciences Division
Department of Radiation and Cellular Oncology
Faculty Sponsor: Jie Zhou, Ph.D. Assistant Professor
The Zhou Lab at the University of Chicago is seeking an enthusiastic and dedicated Postdoctoral Researcher with a strong interest in the development of targeted immunotherapies with chemical biology and protein/antibody engineering approaches. We work at the vibrant interface of chemistry and biology, with a specific focus on the complex dynamics of cell surfaces within the tumor microenvironment (TME). This interdisciplinary position presents an excellent opportunity for a Ph.D. graduate seeking to make significant contributions to the field of protein/antibody engineering & immunotherapy. This position offers an opportunity to work in a dynamic, collaborative environment within the Departments of Radiation and Cellular Oncology and Chemistry at the University of Chicago. You'll work closely with Dr. Zhou, who has extensive experience and training in peptide chemistry, chemical biology, protein/antibody/cell engineering, and immunotherapy. The Zhou Lab is also part of the University of Chicago Comprehensive Cancer Center, offering additional opportunities for collaborative research and career development.
https://voices.uchicago.edu/jzhoulab/research-2/
https://biologicalsciences.uchicago.edu/faculty/jie-zhou
https://chemistry.uchicago.edu/faculty/jie-zhou
The successful candidate will be integral to our ongoing research projects, with a focus on:
-
Elucidating new chemical and biological phenomena or mechanisms on cell membranes contributing to pathological phenotypes.
-
Harnessing these insights to drive the development of next-generation immunotherapies.
-
Engineering small molecules and biologics to enhance our understanding of diseases and facilitate the creation of innovative therapeutics.
The potential candidate will employ a diverse range of methodologies/technologies, including synthetic chemistry, proteomics, functional genomics, and protein/antibody/cell engineering. They will also leverage combinatorial selection technologies such as phage/yeast/cell/virus display, coupled with next-generation sequencing (NGS) and bioinformatics, to advance biological research.
The selected individual is expected to proficiently manage multiple and competing projects and to maintain comprehensive and clear research notes. The successful candidate should be capable of presenting their research progress in internal group meetings and external scientific seminars to the broader scientific community within and outside the University of Chicago. We are seeking candidates who are highly independent, resourceful, and passionate about pioneering cancer immunotherapies.
A Ph.D. or educational equivalent required Ph.D. in chemistry, chemical biology or biochemistry are preferred. Organic chemistry background OR experience of molecular biology experiments, such as cloning, protein expression and purification, is appreciated. Knowledge of basic immunological concepts is appreciated. Experience in combinatorial selection technologies, next-generation sequencing (NGS), and bioinformatics is highly desirable. Ability to write and verbalize clear and complete research findings in the English language. Demonstrated ability to work independently and as a team member.
Compensation in the Biological Sciences Division follows the NIH NRSA Stipend scale. Additional information on benefits and being a postdoc in the University of Chicago Biological Sciences Division can be found at https://bsdpostdoc.uchicago.edu/. The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer
Motivated candidates should submit a curriculum with two references to Dr. Jie Zhou, Ph.D. at jiezhou6@uchicago.edu. We look forward to your application and the potential to welcome you to our team.
了解在X-MOL发布招聘信息的详细流程，请垂询service@x-mol.com
点击“阅读原文”，直达X-MOL求职广场移动版
