关键词：超高分辨率成像 qMRI 射频线圈 磁场检测 临床应用
ISMRM 2025 Abstract #5201
Quantification of cortical and subcortical integrity within clinically feasible scan time using a 16-Tx/64-Rx RF array
Authors
Kerrin J Pine1, Pierre-Louis Bazin2, Evgeniya Kirilina1, and Nikolaus Weiskopf1,3,4
1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany,
2Full brain picture Analytics, Leiden, Netherlands,
3Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth System Sciences, Leipzig University, Leipzig, Germany,
4Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
This is an important step toward the clinical translation of ultra-high-resolution qMRI. The high sensitivity achieved in cortical and brainstem imaging makes the tested RF array a valuable tool for detecting early neurodegeneration at prodromal stages of AD and PD.
Ultra-high-resolution (0.65 mm) quantitative multi-parameter maps (MPM) acquired with maximum acceleration (CS factor 10), resulting in a total acquisition time of 8 minutes using a 64-channel coil.
High-quality qMRI data were obtained within a clinically feasible time frame, allowing for the quantification of submillimeter structures across neocortex, subcortex, and brainstem.
Subnuclei within SN are visible on quantitative R2* maps (arrowed).
Fine details of cortical myeloarchitecture are also visible (e.g. Stria of Gennari in primary visual cortex, arrowed).
Reduction of SNR in quantitative R2* maps in the midbrain due to increased parallel imaging acceleration factors (columns from left to right) is less pronounced for the 64-channel coil (bottom row) compared to the conventional 32-channel coil (top row).
This provides an additional advantage of the 64-channel coil for brainstem imaging with highly accelerated protocols (x16, 5 min total acquisition time for quantitative multi-parametric mapping).
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