Cover story：By combining imaging and sequencing, Chang et al. studied the role of lamin B1 in chromatin architecture and dynamics. They found that lamin B1 depletion leads to detachment of LADs from the nuclear periphery accompanied with global chromatin redistribution and decompaction. Consequently, the inter-chromosomal as well as inter-compartment interactions are increased, but the structure of topologically associating domains (TADs) is not affected. Using live-cell genomic loci tracking, the authors further proved that depletion of lamin B1 leads to increased chromatin dynamics, owing to chromatin decompaction and redistribution toward nucleoplasm. Taken together, these data suggest that lamin B1 and chromatin interactions at the nuclear periphery promote LAD maintenance, chromatin compaction, genomic compartmentalization into chromosome territories and A/B compartments and confine chromatin dynamics, supporting its crucial role in chromatin higher-order structure and chromatin dynamics.
Recollection
Xiaojiang Hu, Jinshuang Ma
Commentary
Alejandro De Los Angeles, Jun Wu
Review
Xiaofei Zhang, Zhuo Ma, Eli Song, Tao Xu
Research Articles
Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells
Lei Chang, Mengfan Li, Shipeng Shao, Chen Li, Shanshan Ai, Boxin Xue, Yingping Hou, Yiwen Zhang, Ruifeng Li, Xiaoying Fan, Aibin He, Cheng Li, Yujie Sun
Drug target inference by mining transcriptional data using a novel graph convolutional network framework
Feisheng Zhong, Xiaolong Wu, Ruirui Yang, Xutong Li, Dingyan Wang, Zunyun Fu, Xiaohong Liu, XiaoZhe Wan, Tianbiao Yang, Zisheng Fan, Yinghui Zhang, Xiaomin Luo, Kaixian Chen, Sulin Zhang, Hualiang Jiang, Mingyue Zheng
Letters
Yujie Tian, Xueheng Guo, Tao Wu, Kuangyu Fei, Li Wu
Correction
Ziyu Sun, Jianyu Ye, Junying Yuan
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