COVER STORY: The Significance of Endosome in Resisting Pathogen Invasion In this cover, the blacksmith shop (endosome) is portrayed as the setting where the defense mechanism against invaders (pathogens) is executed. RAB-10 plays a pivotal role in repelling pathogenic threats, while its partner, EGL-8, is responsible for manufacturing weapons (hydrolyzing PIP2 to DAG). Acting as a liaison between RAB-10 and EGL-8, UNC-16 ensures their preparedness for combat by binding to both proteins. The blacksmith shop is adorned with red lanterns, conveying festive wishes to readers for a prosperous New Year.
Commentary
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