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Protein & Cell Issue 1 of 2022 is released!

Protein & Cell Issue 1 of 2022 is released! Protein Cell
2022-01-27
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Cover story:In the cover paper, Yang et al. investigate the expression of PINK1 in mouse, monkey, and human tissues and found that PINK1 kinase form is more abundant in the primate brains but undetectable in the mouse tissues. Moreover, PINK1 is not enriched in mitochondria in the primate brains. Consistently, depletion of PINK1 causes neuronal loss in the monkey brain without impacting mitochondrial protein expression and morphology. Further, loss of PINK1 reduces protein phosphorylation that is important for neuronal survival. The findings suggest that the impairment of PINK1 kinase but not mitophagy accounts for the selective neurodegeneration in the PINK1 deficient monkey model.

Recollection


A tribute to Professor Yong Zhao

Zheng Tan, Jun Tang, Feng Wang, Xiaocui Li, Yanlian Chen, Songyang Zhou





Preview



PINK1 mediates neuronal survival in monkey 

Zhiyu Sun, Jiangyu Ye, Junying Yuan





REVIEW



The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders 

Kaifan Zhang, Yan Wang, Tianda Fan, Cheng Zeng, Zhong Sheng Sun



Research Articles


PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis 

Weili Yang, Xiangyu Guo, Zhuchi Tu, Xiusheng Chen, Rui Han, Yanting Liu, Sen Yan, Qi Wang, Zhifu Wang, Xianxian Zhao, Yunpeng Zhang, Xin Xiong, Huiming Yang, Peng Yin, Huida Wan, Xingxing Chen, Jifeng Guo, Xiao-Xin Yan, Lujian Liao, Shihua Li, Xiao-Jiang Li




cGAS guards against chromosome endto-end fusions during mitosis and facilitates replicative senescence 

Xiaocui Li, Xiaojuan Li, Chen Xie, Sihui Cai, Mengqiu Li, Heping Jin, Shu Wu, Jun Cui, Haiying Liu, Yong Zhao






LETTERS


Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy 

Bin Li, Yongkun Zhan, Qianqian Liang, Chen Xu, Xinyan Zhou, Huanhuan Cai, Yufan Zheng, Yifan Guo, Lei Wang, Wenqing Qiu, Baiping Cui, Chao Lu, Ruizhe Qian, Ping Zhou, Haiyan Chen, Yun Liu, Sifeng Chen, Xiaobo Li, Ning Sun




Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19 

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Liuqin Yu, Wenjia Chen, Wenshan Hong, Jia Wang, Yao Chen, Kun Wu, Wangheng Hou, Yali Zhang, Shengxiang Ge, Yixin Chen, Quan Yuan, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia






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Protein Cell
Protein & Cell为英文学术月刊,由高等教育出版社、中科院北京生命科学研究院和中国生物物理学会于2010年联合创办,OUP负责海外发行。期刊报道生命科学和生物医学前沿热点,特别关注蛋白质和细胞研究的最新成果及发展动向。
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Protein Cell Protein & Cell为英文学术月刊,由高等教育出版社、中科院北京生命科学研究院和中国生物物理学会于2010年联合创办,OUP负责海外发行。期刊报道生命科学和生物医学前沿热点,特别关注蛋白质和细胞研究的最新成果及发展动向。
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内容122