COVER STORY: Along the sun-drenched shoreline where waves dance with the rhythm of the ocean. Scattered across beach are numerous stones symbolizing over 1,600 distinct small molecules. Much like prospectors panning for gold in a riverbed, four optimized culture systems—LAY, LADY, LUDY, and LKPY—have been identified. Among these, cells cultured in the LAY system exhibit enhanced genomic stability. This research significantly advances the robust induction and long-term maintenance of naïve pluripotency, offering crucial insights for the future application of naïve hPSCs in therapeutic and regenerative contexts.
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Protein & Cell, 2025, 16(10): 837-839
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects
Bernard Moussian
Review
Protein & Cell, 2025, 16(10): 840-857
The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility
Xiaoting Hou, Yu Chen, Bo Zhou, Fengting Liu, Lingyun Dai, Chunbo Chen, Noah D Carrillo, Vincent L Cryns, Richard A Anderson, Jichao Sun, Mo Chen
Research Articles
Protein & Cell, 2025, 16(10): 858-872
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability
Yan Bi, Jindian Hu, Tao Wu, Zhaohui Ouyang, Tan Lin, Jiaxing Sun, Xinbao Zhang, Xiaoyu Xu, Hong Wang, Ke Wei, Shaorong Gao, Yixuan Wang
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Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution
Ping Lu, Yu Zhang, Yueli Cui, Yuhan Liao, Zhenyu Liu, Zhi-Jie Cao, Jun-e Liu, Lu Wen, Xin Zhou, Wei Fu, Fuchou Tang
Letters
Protein & Cell, 2025, 16(10): 896-904
African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile
Fathima Athar, Francesco Morandini, Iqra Fatima, Isabella Silvestri, Sei Joong Kim, Minseon Lee, Xiaoyan Liao, Andrei Sharov, Vladimir Botchkarev, Andrei Seluanov, Vera Gorbunova
Protein & Cell, 2025, 16(10): 905-910
Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity
Brian C Lin, Katarzyna I Jankowska, Upendra K Katneni, Randilu Amarasinghe, Nigam Padhiar, Nobuko Hamasaki-Katagiri, Wells W Wu, Haojie Zhu, Hideki Taguchi, Arnab Ghosh, David D Holcomb, Je-Nie Phue, Sarah E Fumagalli, Darón I Freedberg, Ofer Kimchi, Rong-Fong Shen, Anton A Komar, Zuben E Sauna, Chava Kimchi-Sarfaty
Protein & Cell, 2025, 16(10): 911-915
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus
Qi Yu, Wangjun Fu, Zhenjiang Zhang, Dening Liang, Lulu Wang, Yuanmao Zhu, Encheng Sun, Fang Li, Zhigao Bu, Yutao Chen, Xiangxi Wang, Dongming Zhao
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