Introduction
In the world of chemistry, every molecule has its own unique story and purpose. Today, we are going to explore the scientific mystery behind CAS: 101-80-4, a seemingly insignificant chemical number.
Basic Information
4,4'-Diaminodiphenyl ether (4,4'-ODA), with the chemical formula of C12H12N2O and a molecular weight of 200.24, is an important organic compound. 4,4'-Diaminodiphenyl ether has a series of unique physical and chemical properties. It has a high melting point of about 186-187°C and a boiling point greater than 300°C. It is a fine chemical intermediate for the synthesis of medicines, dyes, insulating materials and flame retardant materials. The polyimide resin synthesized from this substance has the characteristics of high thermal stability, low flammability and excellent mechanical properties. As a high molecular weight monomer, 4,4'-Diaminodiphenyl ether has a wide range of applications in chemical industry, medicine, dyes, pigments, pesticides, electricity, electronics and other fields.
Synthesis Route
(1) Using DNDPE as raw material
1. Metal reduction method
2. Alkali sulfide reduction method
3. Hydrazine hydrate reduction method
4. Catalytic hydrogenation reduction method
5. Photocatalytic reduction method
(2) Using diphenyl ether as raw material
1. Ammonolysis of dihalogenated diphenyl ether
2. Reduction of dinitrosodiphenyl ether
(3) Synthesis of other raw materials
1. 4,4'-diacetyl diphenyl ether as raw material
2. p-Chloroaniline as raw material
3. Hydrogenation reduction of 4-amino-4'-nitrodiphenyl ether
4. Hydroquinone as raw material
Application Field
4,4'-Diaminodiphenyl ether has a wide range of applications in many fields due to its unique chemical properties:
1. Pharmaceutical industry
In the pharmaceutical field, 4,4'-diaminodiphenyl ether is a key intermediate for the synthesis of a variety of drugs. It can be used to synthesize antihypertensive drugs, antidepressants and some anticancer drugs. During the synthesis of these drugs, the amino and benzene rings in the structure provide the necessary reaction sites, allowing the drug molecules to form specific structures and functions.
2. Material science
4,4'-Diaminodiphenyl ether also has a place in material science. 4,4'-Diaminodiphenyl ether is an important monomer for the synthesis of heat-resistant plastics such as polyimide resin, polymaleimide resin, polyamide-imide resin, polyester-imide resin, epoxy resin and polyurethane. These plastics have excellent heat resistance, mechanical properties and insulation properties, and are widely used in electrical fields such as wind power, high-speed rail transportation, new energy vehicles, transformers and electromagnetic wires, as well as electronic fields such as FCCL, package substrate (COF), and graphite heat dissipation film. 4,4'-Diaminodiphenyl ether can also be used as a crosslinking agent to improve the crosslinking degree and performance of materials.
3. Dye industry
4,4'-Diaminodiphenyl ether is also one of the important raw materials for synthetic dyes. By reacting with different compounds, a series of dyes with different colors and properties can be generated. These dyes are widely used in industries such as textiles, plastics and inks, adding rich colors to our lives.
Safety Information
4,4'-Diaminodiphenyl ether should be kept away from strong oxidants. It is toxic. Production equipment should be sealed and the production site should be well ventilated to prevent dust from flying. Operators should wear protective equipment. 4,4'-Diaminodiphenyl ether can cause cancer. Inhalation of vapor or powder or absorption through the skin can cause poisoning. It can damage the human nervous system, cause the blood to form denatured hemoglobin, and has a hemolytic effect.
Conclusion
With the advancement of science and technology and the acceleration of industrialization, the market demand for 4,4'-diaminodiphenyl ether continues to grow. Especially in the fields of electrical engineering, electronics, new energy, etc., the application prospects of 4,4'-diaminodiphenyl ether are very broad. In the future, with the continuous innovation of technology and the improvement of the industrial chain, the production cost of 4,4'-diaminodiphenyl ether will be further reduced, the product quality and performance will continue to improve, and the application field will be further expanded.
By deeply understanding its basic information, synthesis process, physical and chemical properties, application fields, and safety information, we can better grasp its market trends and development prospects, and provide strong support for the development of related fields. At the same time, we should also pay attention to its safety and environmental protection issues, strengthen safety protection and environmental protection measures, and ensure its safety and environmental protection during production and use.
凌凯科技旗下全球数字化医药科研服务平台
Chemenu是LinkChem旗下全球数字化医药科研服务平台，深耕药物分子砌块的设计与研发，旨在赋能早期科学研究，加速药物发现。公司拥有数量庞大、品类多样的高品质、高性价比的分子砌块，并具备优秀的合成化学能力，可为国内外化学和药物研发领域用户提供高质量的有机分子化合物，助力医药研发。
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上海凌凯科技股份有限公司
LinkChem Technology Co., Ltd.
— 上海总部研发中心 —
凌凯科技·LinkChem成立于2011年，是一家专注于有机合成化学、流体工程技术应用的研发型产业化高新技术企业，主要提供小分子化合物研发、生产及商业化解决方案。公司业务横跨且深耕医药、新材料、新能源三大领域，以创新驱动、工程工艺协同，实现对客户多元化需求的快速响应、加速产品服务落地、帮助客户提升整体经济效益。
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上海微新生物科技有限公司
Shanghai Weixin Biotechnology Co., Ltd.
— 化妆品领域创新与应用 —
微新生物是凌凯科技股份旗下的全资子公司。自成立之日起，微新生物就秉承着创新第一、用户满意的宗旨，依托凌凯集团强大的科研实力和完整的产业链，专注于小分子透皮材料及微囊脂质透皮吸收技术在化妆品领域的创新与应用，结合现代植物萃取及香味缓释技术等现代工艺技术，为用户设计功效性芳香疗愈化妆品。
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上海旭流化学科技有限公司
Shanghai XFlow Chemical Technology Co., Ltd.
— 新催化剂应用研究及流动化学技术开发 —
上海旭流化学科技有限公司是一家专业做新催化剂应用研究和流动化学技术开发的公司。公司位于上海市浦东新区康新公路3399号5号楼，在上海拥有1600平方米的研发实验室，拥有员工35名，实验室内拥有CSTR、PFR、微通道反应器、连续空气氧化反应器、连续格式反应器、固定床、滴流床反应器，连续光反应器等等各种流动化学的反应器装置。在江西的5000平方米的中试车间也正在建设之中。公司有工艺开发/反应器设计/工艺模拟/工程设计/工艺安全/分析支持等部门。
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江西亚太科技发展有限公司
Jiangxi Yatai Technology Co., Ltd.
— 中试研究与商业化生产 —
2018年下半年，上海凌凯科技全资收购江西亚太科技，一家高端医药中间体生产工厂。目前江西亚太工厂一、二期改造均已完成，工厂采用国际先进的EHS管理体系，目前已完全具备完善的研发，中控与商业化生产能力。江西亚太科技已于2020年通过跨国知名制药集团如AMGEN,SANOFI等全球知名药企的现场审计。2021年上半年，江西亚太科技自主新建的7000平米研发中心完成装修并全面投入使用，该研发中心集研发、中试、分析和行政办公于一体，并配备高端的连续流技术专用实验室，可同时容纳60-80个新药分子砌块项目的试验开展工作。
江西凌富生物科技有限公司
Jiangxi Linkfull Biological Technology Co., Ltd.
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江西凌富生物科技有限公司是上海凌富药物研究有限公司在景德镇设立的全资子公司，占地面积约214,000㎡，主要提供医药中间体、原料药、新材料单体和锂电池添加剂的商业化生产服务，新材料PI单体设计产能可达3,000吨/年、医药关键中间体达100吨/年。
其母公司上海凌富是由上海凌凯科技股份有限公司与江西富祥药业股份有限公司联合发起并成立。公司凭借上海凌凯科技多年来积累的丰富研发经验和市场终端客户资源，以及江西富祥药业国际质量监管理念接轨的GMP管理体系、科学完善的EHS管理体系，不断开拓并深耕全球国际业务，积极提高企业的研发创新能力，稳步推进小分子化合物研究到商业化生产的一体化综合服务能力。
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