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【源叶】SCI文献引用资讯（一百）

上海源叶生物科技有限公司

2025-11-28

文献引用资讯

ACS Nano（IF=15.8)

文献引用产品

货号	商品名称	CAS号	规格
S16054	三(2-羧乙基)膦盐酸盐	51805-45-9	高纯,98%

摘要：Efficient profiling of circulating extracellular vesicles (EVs) benefits noninvasive cancer diagnosis and therapeutic monitoring, but is technically hampered by tedious isolation, multistep washing, and poor sensitivity. Here, we report multifunctional bubbles that enable self-separation, wash-free, single-step, and ultrasensitive profiling of EV surface markers in plasma samples for early diagnosis and treatment monitoring of lung cancer. In this assay, the buoyancy-dominated bubble is electric field-resistant, allowing EV-responsive release of electroactive probes for electrohydrodynamic nanoshearing force-enhanced hybridization, self-separation from the electrode interface for minimizing noise in electrochemical measurements, and one-step wash-free EV profiling. This assay achieves sensitivity near a single-EV level, shows high specificity against nontarget EVs, and tracks EV phenotypic changes induced by drugs. We further show that this technology can classify plasma samples (n = 111) between cancer patients and noncancer controls with accuracies >95%, enable accurate early diagnosis via machine learning, and monitor pre/post-surgery efficacy with higher accuracy over routine clinical serum markers. This bubble-driven one-step EV assay provides a promising wash-free quantitative tool to enable clinical precision liquid biopsies.

文献链接：

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c16353

Acta Pharmaceutica Sinica BMatter（IF=14.7)

文献引用产品

货号	商品名称	CAS号	规格
B20150	柴胡皂苷D	20874-52-6	分析标准品,HPLC≥98%

摘要：Dendritic cells (DCs) serve as the primary antigen-presenting cells in autoimmune diseases, like rheumatoid arthritis (RA), and exhibit distinct signaling profiles due to antigenic diversity. Type II collagen (CII) has been recognized as an RA-specific antigen; however, little is known about CII-stimulated DCs, limiting the development of RA-specific therapeutic interventions. In this study, we show that CII-stimulated DCs display a preferential gene expression profile associated with migration, offering a new perspective for targeting DC migration in RA treatment. Then, saikosaponin D (SSD) was identified as a compound capable of blocking CII-induced DC migration and effectively ameliorating arthritis. Optineurin (OPTN) is further revealed as a potential SSD target, with Optn deletion impairing CII-pulsed DC migration without affecting maturation. Function analyses uncover that OPTN prevents the proteasomal transport and ubiquitin-dependent degradation of C–C chemokine receptor 7 (CCR7), a pivotal chemokine receptor in DC migration. Optn-deficient DCs exhibit reduced CCR7 expression, leading to slower migration in CII-surrounded environment, thus alleviating arthritis progression. Our findings underscore the significance of antigen-specific DC activation in RA and suggest OPTN is a crucial regulator of CII-specific DC migration. OPTN emerges as a promising drug target for RA, potentially offering significant value for the therapeutic management of RA.

文献链接：

https://www.sciencedirect.com/science/article/pii/S2211383525000371

Nature Communications（IF=14.7)

文献引用产品

货号	商品名称	CAS号	规格
S12066	粘蛋白	84082-64-4	BR，猪肠胃

摘要：Soft robots with real-time volatile organic compound (VOC) perceptivity are promising for dynamic hazard detection. However, reconciling VOC-responsive actuation with an autonomous perception remains challenging. Inspired by Victoria amazonica, which blooms and closes with synchronous color change under environmental stimulations, we developed a solvatophore-induced solvatochromic-piezoelectric material by synthesizing a solvatochromic molecule-modified palygorskite-enhanced polyvinylidene difluoride and realized a VOC-responsive all-fiber actuator with solvatochromic and piezoelectric properties for cooperative visual and electrical perception of volatile organics. Under VOCs, the actuator exhibits bidirectional bending, obvious and stable color change, and characteristic piezoelectric output, allowing the identification of the type and concentration of the VOC. The solvatochromic-piezoelectric actuator demonstrates a large bending curvature of 4.63 cm–1, an ultrafast response speed of up to 4.36 cm–1 s–1, and excellent stability of 1500 actuation cycles without fatigue, with synchronous VOC-induced piezoelectric output reflecting actuation conditions. VOC-responsive solvatochromic and piezoelectric sensing, manipulation, and robots were demonstrated as applications. The VOC-triggered soft robot demonstrates stable motion with synchronous piezoelectric output, capable of autonomously perceiving and responding to environmental VOC. This work presents a widely applicable interactive visual-electronic VOC detection strategy for safety, health, and environmental protection, which could also inspire the exploitation of high-performance responsive fiber materials.