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【源叶】SCI文献引用资讯（一百零二）

上海源叶生物科技有限公司

2025-12-12

文献引用资讯

Nature Communications（IF=14.7)

文献引用产品

货号	商品名称	CAS号	规格
S31479	2',7'-二氯荧光素二乙酸酯	4091-99-0	≥97%(HPLC)

摘要：Solid-liquid contact electrification is a widespread interface phenomenon in nature. Recent research and theory demonstrate that electron transfer during this process holds the potential to initiate interfacial chemical reactions. Here, we design a dual-functional device for generation of H2O2 and energy. Interfacial chemical reactions and solid-liquid contact charging occur simultaneously during the liquid phase flow process. Specifically, electron transfer at the solid-liquid interface induces the formation of hydroxyl radicals (·OH) in the liquid phase, leading to spontaneous generation of H2O2. The transfer of charges at the solid-liquid interface is accompanied by energy transfer. By designing an external electrode structure, we can effectively harvest the energy from the flowing liquid phase, yielding an output power of up to 5.8?kW/m3 for water.

文献链接：

https://www.nature.com/articles/s41467-025-57082-4

Advanced Science（IF=14.3)

文献引用产品

货号	商品名称	CAS号	规格
S24044	伊红染色液	/	进口水溶

摘要：Declining levels of physical activity and fitness in children and youth are linked to negative health outcomes. This study investigates whether maternal exercise can enhance offspring's physical fitness. Our results demonstrate that maternal exercise improves offspring's endurance by changing muscle fiber composition and promoting mitochondrial biogenesis, with benefits lasting across generations. This improvement is associated with changes in DNA methylation, specifically the demethylation of the Slc23a2 gene, which codes for SVCT2, crucial for vitamin C (VC) transport, in F1 and F2 generations. Importantly, VC administration during pregnancy mimics the transgenerational benefits of exercise on offspring fitness, but these benefits are absent in genetic VC deficiency mice. VC supplementation increases TET2 expression in murine and human myogenic cells, regulating DNA methylation, promoting the development of oxidative fibers, and enhancing mitochondrial biogenesis. This study highlights the VC-TET2-SVCT2 pathway as a key mechanism for the transgenerational endurance benefits of maternal exercise, suggesting potential strategies to enhance maternal and child health.

文献链接：

https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/advs.202408912

Advanced Science（IF=14.3)

文献引用产品

货号	名称	CAS	规格
B27081	氧化型辅酶Ⅰ	53-84-9	分析标准品,HPLC≥98%
B21424	烟酰胺	98-92-0	分析标准品,HPLC≥99.5%

摘要：Cervical cancer (CC) is a major health threat to women, with immunotherapies targeting the programmed death receptor 1/programmed death ligand 1(PD-1/PD-L1) axis showing promise but encountering resistance in a significant patient population. This resistance has driven a critical quest to uncover the underlying mechanisms. This study uncovers a novel metabolic axis involving the nicotinamide adenine dinucleotide (NAD+) salvage pathway enzyme nicotinamide phosphoribosyltransferase (NAMPT) and the deacetylase Sirtuin 1 (SIRT1), which regulates PD-L1 expression and nuclear localization in CC. This axis may be a key factor contributing to the resistance observed in immunotherapy. This study reveals that PD-L1 overexpression in cancers is regulated by both transcriptional and post-transcriptional processes. Acetyl-proteomic analysis pinpoints SIRT1 as a central regulator in the deacetylation of histone H3 at lysines 27, which may influence PD-L1 subcellular distribution. This finding reveals the epigenetic control of immune checkpoint proteins by metabolic pathways, offering a new perspective on the regulation of PD-L1. The identification of the NAMPT/SIRT1 metabolic axis as a critical factor suggests that targeting this axis may enhance therapeutic responses.