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图1 CCFM1255对去卵巢大鼠性激素和炎症的调节作用
图2 CCFM1255对雌激素合成相关酶的影响
图3 CCFM1255对血清代谢组谱的影响
图4 CCFM 1255对血清中AAs的影响
图5 肠道菌群分析
Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
Qian Chena,b, Haiqin Chena,b,c,d, Jianxin Zhaoa,b,c,d, Wei Chena,b,c, Gang Wanga,b,c,d,*
a State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China
b School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
c National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
d (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China
*Corresponding author.
Abstract
The decline in ovarian estrogen production is known to have detrimental health consequences and negatively affect the quality of life in menopausal women. Increasing estradiol levels is key to preventing disease in menopausal women. In this study, Lactobacillus gasseri CCFM1255 isolated from healthy infants was found to have a positive effect on estradiol production in ovariectomized rats. CYP19, the key enzyme catalysing the conversion of androgens into estrogens, was upregulated in adipose tissue upon CCFM1255 treatment. Untargeted metabolome analysis and targeted metabolite detection were used to identify the key metabolites altered by CCFM1255 treatment. CCFM1255 treatment significantly improved the serum concentration of glutamine (Gln). A significantly positive correlation was observed between serum Gln and estradiol concentrations. CCFM1255 treatment reshaped the structure of the gut microbiome, which was correlated with certain changes in serum metabolite concentrations. These results indicate that the provision of CCFM1255 as a dietary supplement may be an effective strategy to alleviate menopausal symptoms by increasing circulating estradiol.
Reference:
CHEN Q, CHEN H Q, ZHAO J X, et al. Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome[J]. Food Science and Human Wellness, 2024, 13(6): 3301-3310. DOI:10.26599/FSHW.2023.9250016.
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