Rooted in the 1885 founding philosophy of Momotani Juntendo—"respect the skin's true nature"—the brand began with its founder's gentle skincare formula for his wife, establishing a belief in "non‑invasive support, not forceful intervention." In 1913, Japan's first dermatological research institute was established, and the 1929 Nobel Prize in Chemistry (for coenzyme and enzyme mechanisms) provided the scientific foundation for "skincare that follows the skin's natural rhythm."
RF28 holds that skin has its own circadian rhythm—defending by day, repairing by night—and that aggressive "over‑skincare" undermines its self‑recovery. The core Biorhythm Technology works in harmony with this rhythm: it employs subtilisin, an enzyme homologous to human proteases and known as the "gold of enzymes," to gently dissolve dead cells without compromising the barrier; the FLEXI‑EZ intelligent enzyme‑locking technology aligns with collagen's natural "production‑retention" cycle, using the SE complex to stimulate fibroblast activity while selectively inhibiting collagen‑degrading enzymes, so that anti‑aging works in sync with repair. −45°C freeze‑drying and collaborative R&D across five research institutes all serve to preserve enzyme activity, ensuring that every active ingredient adapts to the skin's own rhythm.
As a premium line under Momotani Juntendo, exclusively for dermatology clinics, RF28 has earned trust from the Imperial Household to users in 33 countries, consistently honoring the principle: "Follow the skin's rhythm, nurture its true beauty."