High Field MRI/MRS Research

With the power to conduct limitless imaging applications, BioSpec® opens up a whole new world of applications. Customers across the world undertake daily investigations into:

• Angiography - flow contrast and flow analysis of the velocity of each voxel for glioblastoma and aneurysm studies
• Cardiology - investigation of cardiac strain, ejection fraction, and septum defects, using triggered sequences or Bruker’s patented IntraGate for navigator based retrospective gating
• Diffusion - visualization of disturbed pathology, such as in multiple sclerosis, epilepsy, and stroke tumors
• fMRI - insight into the brain‘s function
• Molecular MRI - imaging at the cellular level
• Perfusion - with and without CA for tumor- detection, -neoangiogenesis, and -vascularization, and disruption of the blood brain barrier
• Spectroscopy – quantification of metabolic disorders and long term changes in metabolic processe

Leading scientists worldwide are taking their research closer to the molecular and cellular level thanks to BioSpec®. Designed for the emerging market of preclinical imaging and molecular MRI, its innovative modular concept enables virtually any small animal MR imaging application in life science, biomedical, and preclinical research.

BioSpec® already brings proven performance, safety, convenience, and future-proof cost-effective operation to over 600 labs worldwide. With our new multimodal animal platforms and accessories and our latest generation ParaVision® 6 software more users than ever can access a new level of research quicker than they think.

Key Benefts
• Cost effective - Helium zero boil off and Nitrogen-free for reduced maintenance costs and longer service intervals
• Scalable – upgradeable electronics, options, and accessories to keep your system at the cutting edge
• Compatible – multimodal animal handling solutions for use with all Bruker preclinical modalities
• Intuitive – with Bruker’s gold standard preclinical imaging software, ParaVision® 6, users can start scanning immediately
• Proven – more than 30 methods with various contrast modules and hundreds of measurement protocols designed and tested on mice and rats to guarantee the highest image quality

Key Technologies
• Field strengths – 4.7 to 21 Tesla ultra-shielded superconducting magnets with reduced stray field
• Bore sizes – 11 to 40 cm for optimal working space
• Gradient diameters – 6, 9, 12, 20, 26 cm, with 6 and 12 cm gradients available as inserts (dual gradients)
• Gradient strength – up to 1000 mT/m for highest duty cycles
• Shim sets – Full 3rd order (6 cm) and 2nd order (9-26 cm) for best homogeneity

The World’s Leading Hardware

Gradients
The high performance BGA-S HP gradient series delivers unsurpassed slew rates, up to 9000 T/m/s, and gradient strengths up to 1000 mT/m. Integrated shim coils enable optimal feld homogeneity even at the highest magnetic felds. The dedicated cooling design results in unique duty cycle specifcations for high end fMRI applications. Gradients can be used as inserts and thanks to automatic hardware recognition they are easily exchangeable.

RF-coils
RF-coils are the interface to the sample and have a major impact on quality, acquisition time, and workflow. Bruker delivers application-optimized RF-coils for head, brain, cardio, abdomen, spine, and arterial spin labeling, as well as RF-coils for non-proton applications for mice and rats. The closed-loop helium-cooled MRI CryoProbe™ series RF-coils are available for mice and rats and offer uncompromised performance for highest signal-to-noise requirements.

AVANCE™ III HD Electronics
The AVANCE III HD system architecture delivers an unprecedented level of digital control for high quality and high speed MR imaging and spectroscopy applications, while offering great flexibility and highly scalable transmitter and receiver channel architecture. MRI scanner operation has never been easier, with single push-button scanner operation including a new power management and complete hardware detection for RF-coils, gradients, shims, and signal routing.

A Quantum Leap in Neuro Imaging

Unique Technology for Outstanding Results

Based on very low temperature, helium-cooled, closedcycle RF coils and preamplifers, the unique MRI CryoProbe delivers a signifcant increase in SNR over equivalent room-temperature RF-coils in routine in vivo MRI applications. Animal handling and supervision of the MRI CryoProbe is very similar to standard room temperature RF-coils. MRI CryoProbe cooling can be accomplished outside the magnet ensuring optimum usage of scanner time.

MRI CryoProbes provide tremendous benefts compared to standard room temperature RF-coils:
• Increased signal-to-noise ratio of up to factor 5
• Higher resolution in vivo down to 20 µm
• Shorter measurements times directly enable lower costs per sample and higher productivity
• Access to new applications not possible with room temperature RF-coils (high resolution, fMRI)
• Shorter durations of anesthesia

Software for Performance, Flexibility, and Routine Optimization

Enhanced Productivity
A redefned and intuitive workflow introduces optimized, application-oriented and in vivo validated experimental protocols, an interactive 3D scan planning viewport, advanced image analysis tools, and automatic reporting. The new scan queue enables the use of scan programs with automatic copy references in order to minimize user interaction. Thanks to its DICOM-based data exchange module, ParaVision 6 seamlessly integrates with data from multimodal imaging studies employed in many preclinical research labs.

High Performance
With true 64-bit architecture and parallel multi-core acquisition and reconstruction, ParaVision 6 delivers highresolution 3D images up to virtually unlimited size. It includes an extensive set of routine and advanced imaging sequences, offers seamless integration of parallel transmission techniques and navigator handling, and incorporates a unique, integrated feld map-based shimming procedure.

Integrated real-time optimization features enable dynamic adjustment of parameters during scanning, provide integration of navigator scans, and provide on-the-fly pulse generation for optimum slice profles.

Advanced users will welcome the fully integrated method development environment that enables them to redefine their own boundaries in imaging research.

Compatibility
ParaVision 6 is designed to beneft all modern Bruker MRI platforms from AVANCE™ II to AVANCE™ III HD, as well as ICON™ benchtop MRI and MPI (magnetic particle imaging) systems. AVANCE III HD systems in particular beneft from new power management features that display the state of the system and its components, in addition to providing push-button system start-up and shutdown.

Setting New Standards in Preclinical MRI
Delivering a quantum leap in ease of use, the redesigned ParaVision 6 workflow is designed with preclinical imaging in mind, featuring a newly developed user interface and easy parameter handling. A guided imaging workflow produces consistent results and lowers the learning curve for biomedical researchers new to MRI. A contextsensitive view reduces complexity by visualizing only parameters relevant to the operations at hand, ensuring intuitive and focused operation.

Keep Your System at the Cutting-Edge

Multimodal Mouse Bed
Bruker’s multimodal beds accomodate mice and rats and enable a great variety of applications. They feature a bite bar for head fxation and have provisions for the use of fudicial markers, temperature stabilization, anesthesia implementation and exhaust, and monitoring of physiological signals (ECG, respiration, temperature), which can be used for triggering. The one-snap system of all control and monitoring lines allow the beds to be quickly transferred from one imaging system to the next while keeping the animal’s position stable and reproducible. Automatic cut-off of anesthesia when the bed is not connected to the base assures user safety within the laboratory.

AutoPac
AutoPac, the automatic positioning system simplifes animal handling via laser positioning and electronic table driving. A touch pad allows positioning adjustment with an accuracy of 100 µm. Additionally, the AutoPac RF cover eliminates the necessity for a Faraday cage.

Bruker‘s commitment to providing the highest quality of service and support means maximum reliability, productivity, and performance from your MRI system. From the initial site evaluation, through system installation, and throughout the lifetime of your instrument, Bruker’s service program is dedicated to providing personalized support.

Site Planning - Customized Services
Proper site planning for your MRI scanner is the frst step in ensuring optimum system performance. Beyond the site-planning guide, Bruker’s technical departments can provide space-planning and site preparation services tailored to your individual needs. Bruker‘s site-specifc plans, based on your equipment specifcations and local architectural drawings, can be used to develop bidding
documentation and help estimate construction costs.

Responsive Technical and Software Support
Should you ever have questions or require assistance with your MRI system, Bruker‘s free service & support hotlines are your frst point of call. Support center engineers and scientists will quickly and effciently gather key information, suggest relevant diagnostics, and provide a swift solution. Worldwide support centers will liaise with your local service team, enabling on site diagnosis, part replacement, repair, or preventative maintenance.