2024年4月22日，华大生命科学研究院联合国内外多个研究团队在 Nature 期刊发表题为“Multimodal cell atlas of the ageing human skeletal muscle” 的研究论文。研究利用单细胞核转录组、单细胞核染色质开放组技术，结合组织染色，构建了包含31个不同性别和地区背景的人群下肢肌肉骨骼肌多模态单细胞图谱。通过对387000多个细胞/核的深入分析，研究人员详细描述了细胞群体在衰老过程中的变化，包括老年人群新出现的细胞群体，以及这些变化背后的细胞特异性特征和多细胞间的网络互动特性。该研究在转录组学和表观遗传学层面上深入探讨了与骨骼肌衰老相关的分子机制。
非常荣幸能有赛库CellCook相关产品被研究者使用并在文章中被引用。赛库公司作为一家提供细胞整体解决方案的公司，多年来在产品品质及相关技术上的积累，得到了越来越多的客户信任。
以此为契机，我们在PMC数据库检索了部分2024年上半年发表的引用 了赛库CellCook产品的文章，并进行了简单的汇总分析。我们非常欣喜地看到，赛库的客户已经遍布中国，赛库的产品也出现在越来越多的高分杂志上。越来越多而且水平也越来越高的客户成果展现在世界舞台，这也让我们拥有了更多的成就感。这些都激励着我们今后要提供更好的产品和服务，更好地助力生命科学研究者。
附1：2024上半年被引文章汇总列表
| 序号 | 期刊 | 2023影响因子IF | 第一作者单位 | 被引用产品 |
| 1 | Oncogenesis | 5.9 | 山东大学齐鲁医学院 | 细胞系 |
| 2 | Theranostics | 12.4 | 广东省人民医院 | 细胞系 |
| 3 | J Cell Mol Med | 4.3 | 湖南中药大学 | 细胞系 |
| 4 | Cell Commun Signal | 8.2 | 南方科技大学医学院 | 细胞系 |
| 5 | iScience | 4.6 | 福建医科大学附属三明第一医院 | STR细胞鉴定 |
| 6 | Nat Commu | 14.7 | 中山大学药学院 | 细胞系 |
| 7 | PeerJ | 2.3 | 深圳市儿童医院 | 细胞系 |
| 8 | PLoS One | 2.9 | 川北医学院附属医院 | 细胞系 |
| 9 | J Biol Chem | 4 | 东南大学 | CCK-8试剂盒 |
| 10 | J Clin Transl Hepatol | 3.1 | 中山大学附属第三医院 | 胎牛血清FBS |
| 11 | J Transl Med | 6.1 | 东南大学 | CCK-8试剂盒 |
| 12 | J Exp Clin Cancer Res | 11.4 | 福建医科大学 | CCK-8试剂盒 |
| 13 | Nature | 50.5 | BGI 华大 | 胎牛血清FBS |
| 14 | J Cancer Res Clin Oncol | 2.7 | 南京大学医学院 | 细胞系 |
| 15 | J Cancer Res Clin Oncol | 2.7 | 青岛大学附属医院 | 细胞系 |
| 16 | Cancer Med | 2.9 | 哈尔滨医科大学 | 细胞系 |
| 17 | Cell Rep Med | 11.7 | 天津医科大学/国家肿瘤临床医学研究中心 | 细胞系 |
| 18 | Biomed Rep | 2.3 | 东南大学 | 细胞系 |
| 19 | Cell Mol Life Sci | 6.2 | 大连医科大学 | 细胞系 |
| 20 | CNS Neurosci Ther | 4.8 | 南通大学附属医院 | 细胞系 |
| 21 | Exp Hematol Oncol | 9.4 | 南京大学医学院 | 细胞系 |
| 22 | Heliyon | 3.4 | 温州医科大学第三附属医院 | 细胞系 |
| 23 | Cell Mol Biol Lett | 9.2 | 南京中医药大学 | 细胞系 |
| 24 | Adv Sci (Weinh) | 14.3 | 中山大学药学院 | 细胞系 |
| 25 | Cell Death Discov | 6.1 | 河北医科大学第四医院 | 细胞系 |
| 26 | J Tradit Chin Med | 2 | 上海中医药大学附属曙光医院 | 细胞系 |
| 27 | BMC Med | 7 | 华西医院 | CCK-8试剂盒 |
| 28 | PeerJ | 2.3 | 广州医科大学第二附属医院 | 细胞系 |
| 29 | Exp Ther Med | 2.4 | 南方医科大学附属南方医院 | 细胞系 |
| 30 | Stem Cells | 4 | 南开大学医学院 | 细胞系 |
| 31 | Clin Transl Med | 7.9 | 华中科技大学附属协和医院 | 细胞系 |
| 32 | Adv Sci (Weinh) | 14.3 | 福建医科大学 | 细胞系 |
| 33 | J Cancer | 3.3 | 皖南医学院第二附属医院 | 细胞系 |
| 34 | Molecules | 4.2 | 武汉大学药学院 | 细胞系 |
| 35 | Am J Cancer Res | 3.6 | 广东省第二人民医院 | 细胞系、 1640培养基 |
| 36 | J Hepatocell Carcinoma | 4.2 | 广西医科大学第一附属医院 | 细胞系 |
| 37 | BMC Cancer | 3.4 | 东南大学 | 细胞系 |
| 38 | Cancer Cell Int | 5.3 | 广东省人民医院 | 细胞系 |
| 39 | Cancer Sci | 4.5 | 东吴大学第二附属医院 | 细胞系 |
| 40 | Respir Res | 4.7 | 中山大学附属第三医院 | 细胞系 |
| 41 | Nat Commu | 14.7 | 南方科技大学 | 细胞系 |
| 42 | J Cancer | 3.3 | 中山大学附属第一医院 | CCK-8试剂盒 |
| 43 | Int J Mol Sci | 4.9 | 兰州大学口腔医学院 | 细胞系 |
| 44 | Discov Oncol | 2.8 | 郑州大学 | 细胞系 |
| 45 | Hum Genomics | 3.8 | 东南大学医学院 | 细胞系、 胎牛血清FBS |
| 46 | iScience | 4.6 | 山东第一医科大学 | STR细胞鉴定 |
| 47 | Sci Rep | 3.8 | 广西医科大学第一附属医院 | RT-PCR PRIMERS |
| 48 | World J Gastroenterol | 4.3 | 右江民族医学院 | 细胞系 |
| 49 | Mater Today Bio | 8.7 | 吉林大学第二医院 | 细胞系 |
附2：2024上半年赛库 Cellcook产品被引文献 （来自PMC数据库）
1. USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling。Oncogenesis. 2024 Dec; 13(1): 23. Published online 2024 Jun 21. doi: 10.1038/s41389-024-00524-3
2. FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux。Theranostics. 2024; 14(9): 3719–3738. Published online 2024 Jun 17. doi: 10.7150/thno.92771
3. Amentoflavone reverses epithelial‐mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis。J Cell Mol Med. 2024 Jun; 28(11): e18442. Published online 2024 Jun 6. doi: 10.1111/jcmm.18442
4. GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma。Cell Commun Signal. 2024; 22: 303. Published online 2024 Jun 3. doi: 10.1186/s12964-024-01678-8
5. Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma。iScience. 2024 Jun 21; 27(6): 109997. Published online 2024 May 16. doi: 10.1016/j.isci.2024.109997
6. Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity。Nat Commun. 2024; 15: 4162. Published online 2024 May 16. doi: 10.1038/s41467-024-48503-x
7. Hsa_circ_0009096/miR-370-3p modulates hepatic stellate cell proliferation and fibrosis during biliary atresia pathogenesis。PeerJ. 2024; 12: e17356. Published online 2024 May 14. doi: 10.7717/peerj.17356
8. Downregulation of RCN1 inhibits esophageal squamous cell carcinoma progression and M2 macrophage polarization。PLoS One. 2024; 19(5): e0302780. Published online 2024 May 7. doi: 10.1371/journal.pone.0302780
9. Hhatl ameliorates endoplasmic reticulum stress through autophagy by associating with LC3。J Biol Chem. 2024 Jun; 300(6): 107335. Published online 2024 May 4. doi: 10.1016/j.jbc.2024.107335
10. Dopamine Inhibits the Expression of Hepatitis B Virus Surface and e Antigens by Activating the JAK/STAT Pathway and Upregulating Interferon-stimulated Gene 15 Expression。J Clin Transl Hepatol. 2024 May 28; 12(5): 443–456. Published online 2024 Apr 30. doi: 10.14218/JCTH.2024.00051
11. Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid。J Transl Med. 2024; 22: 401. Published online 2024 Apr 30. doi: 10.1186/s12967-024-05157-z
12. Tumor-suppressive miR-4732-3p is sorted into fucosylated exosome by hnRNPK to avoid the inhibition of lung cancer progression。J Exp Clin Cancer Res. 2024; 43: 123. Published online 2024 Apr 23. doi: 10.1186/s13046-024-03048-1
13. Multimodal cell atlas of the ageing human skeletal muscle。Nature. 2024; 629(8010): 154–164. Published online 2024 Apr 22. doi: 10.1038/s41586-024-07348-6
14. Prevotella intermedia boosts OSCC progression through ISG15 upregulation: a new target for intervention。J Cancer Res Clin Oncol. 2024; 150(4): 206. Published online 2024 Apr 21. doi: 10.1007/s00432-024-05730-5
15. Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway。J Cancer Res Clin Oncol. 2024; 150(4): 202. Published online 2024 Apr 17. doi: 10.1007/s00432-024-05711-8
16. The RNA‐binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA。Cancer Med. 2024 Apr; 13(7): e7129. Published online 2024 Apr 15. doi: 10.1002/cam4.7129
17. Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation。Cell Rep Med. 2024 May 21; 5(5): 101505. Published online 2024 Apr 12. doi: 10.1016/j.xcrm.2024.101505
18. miRNAmRNA network contributes to HBVrelated hepatocellular carcinoma via immune infiltration induced by GRB2。Biomed Rep. 2024 Jun; 20(6): 90. Published online 2024 Apr 11. doi: 10.3892/br.2024.1777
19. Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma。Cell Mol Life Sci. 2024 Dec; 81(1): 179. Published online 2024 Apr 11. doi: 10.1007/s00018-024-05210-6
20. Identifying of immune‐associated genes for assessing the obesity‐associated risk to the offspring in maternal obesity: A bioinformatics and machine learning。CNS Neurosci Ther. 2024 Mar; 30(3): e14700. Published online 2024 Mar 27. doi: 10.1111/cns.14700
21. Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment。Exp Hematol Oncol. 2024; 13: 33. Published online 2024 Mar 21. doi: 10.1186/s40164-024-00500-y
22. Prognostic prediction using a gene signature developed based on exhausted T cells for liver cancer patients。Heliyon. 2024 Mar 30; 10(6): e28156. Published online 2024 Mar 16. doi: 10.1016/j.heliyon.2024.e28156
23. MRE11A: a novel negative regulator of human DNA mismatch repair。Cell Mol Biol Lett. 2024; 29: 37. Published online 2024 Mar 14. doi: 10.1186/s11658-024-00547-z
24. Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin‐Induced Liver Injury。Adv Sci (Weinh) 2024 May; 11(19): 2308771. Published online 2024 Mar 13. doi: 10.1002/advs.202308771
25. NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence。Cell Death Discov. 2024; 10: 131. Published online 2024 Mar 12. doi: 10.1038/s41420-024-01892-w
26. Chang'an decoction (肠安方) alleviates endoplasmic reticulum stress by regulating mitofusin 2 to improve colitis。J Tradit Chin Med. 2024 Jun 15; 44(3): 427–436. Published online 2024 Mar 8. doi: 10.19852/j.cnki.jtcm.20240308.001
27. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro。BMC Med. 2024; 22: 96. Published online 2024 Mar 5. doi: 10.1186/s12916-024-03314-1
28. Hsa_circ_0001615 downregulation inhibits esophageal cancer development through miR-142-5p/β-catenin。PeerJ. 2024; 12: e17089. Published online 2024 Mar 4. doi: 10.7717/peerj.17089
29. CHL1 inhibits cell proliferation, migration and invasion by regulating the NFκB signaling pathway in colorectal cancer。Exp Ther Med. 2024 Apr; 27(4): 165. Published online 2024 Feb 26. doi: 10.3892/etm.2024.12454
30. HucMSCs Delay Muscle Atrophy After Peripheral Nerve Injury Through Exosomes by Repressing Muscle-Specific Ubiquitin Ligases。Stem Cells. 2024 May; 42(5): 460–474. Published online 2024 Feb 21.doi: 10.1093/stmcls/sxae017
31. LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m6A modification in triple‐negative breast cancer。Clin Transl Med. 2024 Feb; 14(2): e1583. Published online 2024 Feb 19. doi: 10.1002/ctm2.1583
32. Escherichia coli‐Induced cGLIS3‐Mediated Stress Granules Activate the NF‐κB Pathway to Promote Intrahepatic Cholangiocarcinoma Progression。Adv Sci (Weinh) 2024 Apr; 11(16): 2306174. Published online 2024 Feb 17. doi: 10.1002/advs.202306174
33. MicroRNA-485-5p targets keratin17 to regulate pancreatic cancer cell proliferation and invasion via the FAK / SRC / ERK pathway。J Cancer. 2024; 15(7): 2033–2044. Published online 2024 Feb 17.doi: 10.7150/jca.90689
34. Teadenol B as a Component of Microorganism-Fermented Tea Extract Inhibited Breast Cancers by Promoting Autophagy。Molecules. 2024 Feb; 29(4): 872. Published online 2024 Feb 16. doi: 10.3390/molecules29040872
35. Arsenic trioxide suppresses lung adenocarcinoma stem cell stemness by inhibiting m6A modification to promote ferroptosis。Am J Cancer Res. 2024; 14(2): 507–525. Published online 2024 Feb 15. doi: 10.62347/KFAX9239
36. RAD21: A Key Transcriptional Regulator in the Development of Residual Liver Cancer。J Hepatocell Carcinoma. 2024; 11: 285–304. Published online 2024 Feb 5. doi: 10.2147/JHC.S447915
37. G6PD and machine learning algorithms as prognostic and diagnostic indicators of liver hepatocellular carcinoma。BMC Cancer. 2024; 24: 157. Published online 2024 Jan 31. doi: 10.1186/s12885-024-11887-6
38. An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2。Cancer Cell Int. 2024; 24: 49. Published online 2024 Jan 30. doi: 10.1186/s12935-024-03245-0
39. Tumor‐derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression。Cancer Sci. 2024 Apr; 115(4): 1141–1153. Published online 2024 Jan 29. doi: 10.1111/cas.16080
40. Circ-phkb promotes cell apoptosis and inflammation in LPS-induced alveolar macrophages via the TLR4/MyD88/NF-kB/CCL2 axis。Respir Res. 2024; 25: 62. Published online 2024 Jan 29.doi: 10.1186/s12931-024-02677-6
41. The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus。Nat Commun. 2024; 15: 812. Published online 2024 Jan 27. doi: 10.1038/s41467-024-45202-5
42. Cuproptosis-related genes score and its hub gene GCSH: A novel predictor for cholangiocarcinomas prognosis based on RNA seq and experimental analyses。J Cancer. 2024; 15(6): 1551–1567. Published online 2024 Jan 21. doi: 10.7150/jca.92327
43. Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma。Int J Mol Sci. 2024 Jan; 25(2): 1031. Published online 2024 Jan 14. doi: 10.3390/ijms25021031
44. GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis。Discov Oncol. 2024 Dec; 15: 8. Published online 2024 Jan 12. doi: 10.1007/s12672-024-00860-1
45. A novel upregulated hsa_circ_0032746 regulates the oncogenesis of esophageal squamous cell carcinoma by regulating miR-4270/MCM3 axis。Hum Genomics. 2024; 18: 3. Published online 2024 Jan 10. doi: 10.1186/s40246-023-00564-7
46. CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway。iScience. 2024 Feb 16; 27(2): 108843. Published online 2024 Jan 9. doi: 10.1016/j.isci.2024.108843
47. Paclitaxel-induced inhibition of NSCLC invasion and migration via RBFOX3-mediated circIGF1R biogenesis。Sci Rep. 2024; 14: 774. Published online 2024 Jan 8. doi: 10.1038/s41598-024-51500-1
48. Mechanistic research: Selenium regulates virulence factors, reducing adhesion ability and inflammatory damage of Helicobacter pylori。World J Gastroenterol. 2024 Jan 7; 30(1): 91–107. Published online 2024 Jan 7. doi: 10.3748/wjg.v30.i1.91
49. Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis。Mater Today Bio. 2024 Feb; 24: 100943. Published online 2024 Jan 4. doi: 10.1016/j.mtbio.2024.100943
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赛库（Cellcook）是一家专注于细胞相关技术、服务及产品的高科技企业，公司坐落在优雅美丽的广州国际生物岛。赛库（Cellcook）聘请多名生命科学领域的国家杰出青年基金获得者作为科学顾问，同时拥有朝气蓬勃的年轻队伍，具有强大的研发和技术支持能力。赛库（Cellcook）提供细胞整体解决方案，建立了完善鉴定、种类齐全的细胞资源库，并提供专业的细胞相关技术服务和配套试剂。公司已建立完整的研发、生产和质控体系，在广州国际生物岛拥有高标准研发实验室与细胞工厂，保证了为客户提供优异的产品及服务。我们的客户已经覆盖全中国所有的地区，涵盖的领域包括医学科研实验室、生物制药研发中心、分子诊断企业研发中心等。我们密切注视细胞技术领域的发展，并且致力于相关前沿技术的应用转化。
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