文献速递丨IF高达16的【纳米载体力学】研究背后，藏着哪些科研灵感？

文章题目：

Nanocarrier Nanomechanics: A Key to Unlocking Endocytosis in Cancer Cells Navigating Epithelial−Mesenchymal Transition Dynamics

文章摘要：

The mechanical properties of nanocarriers and the ability of tumor cells to sense mechanical cues are critical factors in regulating cellular internalization. During epithelial–mesenchymal transition (EMT), tumor cells undergo changes that enhance their invasiveness, but how these changes affect their ability to sense mechanical cues, thereby impacting drug delivery efficiency and treatment effects, is still unknown. Here, we synthesized chitosan nanoparticles (CSNPs) with different Young’s moduli ranging from 0.325 to 18.25 MPa. Our findings revealed that as EMT progresses, tumor cells exhibited enhanced internalization capacity, attributing to the elevated integrin expression by EMT. During the cellular internalization of CSNPs with different Young’s moduli, the stiffer CSNPs displayed more internalization in tumor cells. It was due to the upregulation of p-FAK expression after the integrin of cells sensed stronger mechanical cues generated by stiffer CSNPs, resulting in promoted F-actin polymerization, ultimately achieving more cellular internalization. After loading doxorubicin (DOX) into CSNPs (DOX-CSNPs), the stiffer DOX-CSNPs exhibited higher inhibitory ability, with mesenchymal phenotype tumor cells displaying the highest treatment effect. Taken together, our work demonstrated how the mechanical properties of nanocarriers affect cellular internalization across different EMT stages and provided a mechanical-based nanocarrier engineering strategy for cells undergoing EMT.

原文链接：

https://doi.org/10.1021/acsnano.5c09366

引用产品及培养细胞：FBS-303  SV-HUC-1 T24

细胞清单，扫码查看

· ·奖励对象及规则 · ·

 2025年05月01日-2025年12月31日 

1.奖励对象

使用金源康生物胎牛血清产品FBS-300、FBS-301、FBS-303，并在SCI期刊杂志发表文章，且文章正文中在使用产品的位置标注相应产品型号及我公司名“Inner Mongolia Jinyuankang Biotechnology Co., Ltd”或“Jin Yuan Kang Biotechnology”均可参与本次活动。

2. 奖励说明

1) 申请人论文已发表三个月内，且为第一作者或通讯作者，第一作者与通讯作者同时申请，以通讯作者为准；同一申请人若有多篇见刊论文引用同一产品，则按最高影响因子所在档实施单次最大奖励，不予重复奖励；

2) 提供文献全文(PDF格式)以及文章链接，并同意在金源康及其旗下子品牌后续推广展示；

3) 每篇文献仅限领取一次奖励；

4) 影响因子(IF)以申请奖励时间为准；

5) 试用装产品，不参与活动奖励；

6) 经公司审核通过后，我们会尽快与申请人联系，确定购物卡及赠送细胞的派发。

· ·活动参与方式 · ·

扫描下方二维码，填写问卷，7个工作日内，工作人员将与您联系。

完整填写信息丨申请文献奖励

扫描下方二维码，关注“金源康生物”微信公众号。

“金源康生物”微信公众号

回复“文献奖励”关键词，弹出问卷链接，完成问卷填写并提交。

关注“金源康生物”微信公众号，点击如图所示【文献奖励报名】菜单栏，可直接申请。