自2025年1月推出 "SCI论文奖励活动" 后，我们收获了多篇高质量研究论文，其中最高影响因子（IF）27.4分！闪耀创新引擎，驱动科研锐意进取！金源康生物将以卓越品质，驱动科研创新突破。
高分文献速递
客户单位：苏州大学纳米学院
期刊：Journal Of The American Chemical Society（JACS）
影响因子（IF）：15.6
文章题目：
Engineered Nano-micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization
文章摘要：
Gasdermin-mediated pyroptosis represents a promising immunotherapeutic strategy, yet requires precise tumor-specific activation. Magnetic hyperthermia therapy (MHT) has the potential to induce pyroptosis in hepatocellular carcinoma (HCC), while its efficacy is limited by suboptimal heating efficiency and tumor resistance. Herein, we developed an innovative magnetic-metallo-immunotherapeutic platform by engineering nanomicro pyroptosis generators, thereby enhancing transarterial embolization (TAE). Through compositional and structural optimization, Zn–Fe3O4@Co–Fe3O4 core–shell nanocubes (ZnCo–Fe3O4 CSNCs) with enhanced magnetothermal properties were obtained, which exhibited significantly improved saturation magnetization (Ms) and coercivity (Hc). These nanocubes were further assembled via microfluidic technology into magnetic microspheres (MSs) with tunable sizes, integrating the therapeutic functions of TAE and MHT. Under an alternating magnetic field (AMF), the ZnCo–Fe3O4 MSs demonstrated temperature-dependent ion release and localized hyperthermia while simultaneously inhibiting heat shock protein (HSP) upregulation through metabolic interference. This orchestrated therapeutic cascade effectively triggered pyroptosis in cancer cells, subsequently activating the immune response and thereby enhancing the efficacy of magnetic-metallo-immunotherapy. The strategic combination of this platform with immune checkpoint blockade (ICB) therapy provoked comprehensive systemic immune activation, markedly enhancing treatment efficacy and suppressing the progression of both primary tumors and distant tumors. Notably, ZnCo–Fe3O4 MSs demonstrated an exceptional capacity to modulate the immunosuppressive tumor niche while substantially improving TAE performance through their unique embolization-immunomodulation functionality. Overall, this study highlights new avenues for exploring pyroptosis-mediated magnetic-metallo-immunotherapy for effective cancer therapy.
原文链接：
https://pubs.acs.org/doi/10.1021/jacs.5c06039
引用产品及培养细胞：FBS-303 H22，4T1
文献奖励参与方式：
助力科研，一路同行 | 2025 SCI论文奖励活动全新升级
