高分文献速递
客户单位：四川大学
期刊：Materials Today
影响因子（IF）：22
文章题目：
Ultrasound-activated cyclic brush polymer nanotheranostic system for multimodal imaging and therapy in diabetes-induced osteoarthritis
文章摘要：
Diabetes-induced osteoarthritis (DOA) is a degenerative disease of bone and joint induced or aggravated by metabolic disorder of diabetes, with significant concealment and disability. Clinical evidence indicates that traditional osteoarthritis therapies are difficult to meet the complex pathological microenvironment of DOA and precise theranostics of deep lesions remains a significant challenge. Herein, we have developed an advanced NIR-immunotheranostic nanosystem (ACBPD) that integrates cyclic brush polymer-based prodrug immunotherapeutics and imaging agents for precise DOA real-time non-invasive diagnosis with multi-pronged DOA treatments. The sustained superlubricity (COF ∼ 0.016 for 14,400 cycles) and immunomodulatory properties of ACBPD significantly alleviated joint destruction caused by glucose metabolism disorder (89.5 % reduction in osteophytes). Furthermore, Ultrasound-activated hyperthermia ACBPD with high photothermal conversion efficiency (61.8 %) assisted self-adaptive metformin release, activating the PI3K-Akt and calcium signaling pathways, while inhibiting NF-κB inflammatory pathways, thereby regulating T2DM-induced glucotoxicity and oxidative stress to reconstruct DOA osteoimmune microenvironment homeostasis. Notably, the unique photoacoustic and contrast-enhanced ultrasound imaging capabilities of ACBPD allow for precise joint depiction and real-time dynamic monitoring of DOA joint oxygen saturation (79 %). Therefore, this work realizes the theranostics of DOA for the first time, offering new avenues for clinical management of deep bone-related diseases.
原文链接：
https://doi.org/10.1016/j.mattod.2025.11.025
引用产品及培养细胞：BS-1105 软骨细胞，内皮细胞
