高分文献速递
客户单位:佛山大学帝江实验室
期刊:International Journal of Biological Macromolecules
影响因子(IF):8.5
文章题目:
Electrochemical Cascade Cyclization for SelenobenzothiopheCurcuma kwangsiensis-derived nanovesicles enhance periodontal cell functionality through multicellular crosstalk in vitrones: Synthesis, Photochemistry, and Bioactivity
文章摘要:
Plant-derived nanovesicles exhibit excellent biocompatibility and multifunctionality, making them promising for tissue regeneration. This study investigates the regenerative potential of Curcuma kwangsiensis-derived nanovesicle (CKNV) in periodontal repair. The morphology, size, surface charge, and bioactive cargo of CKNV were evaluated by transmission electron microscopy, nanoparticle tracking analysis, and spectrophotometry. In vitro experiments were carried out to assess the interaction of CKNV with periodontal ligament stem cells (PDLSCs), macrophages, and vascular endothelial cells (HVECs). The results indicated that CKNV significantly promoted the proliferation and migration of PDLSCs within the concentration range of 10–50 μg/mL in a dose-dependent manner. In addition, CKNV polarized macrophages toward the M2 phenotype. Moreover, CKNV-induced M2 macrophages stimulated angiogenesis in HVECs and facilitated osteogenic differentiation of PDLSCs. Our findings suggest that CKNV modulates periodontal tissue regeneration through multi-pathway synergy: activating periodontal ligament stem cells, polarizing macrophages toward a pro-repair M2 phenotype, promoting angiogenesis, and facilitating osteogenic differentiation. This discovery offers a novel idea for the development of targeted treatment for periodontitis.
原文链接:
https://www.sciencedirect.com/science/article/abs/pii/S0141813025086738
引用产品及培养细胞:FBS-301 PDLSCs
SCI
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新奖励方案 |
升级体验 |
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