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全球领先的开放式生物制药技术平台公司药眀生物（WuXi Biologics, 2269.HK）与专注于肿瘤免疫和神经退行性疾病抗体新药开发的韩国生物技术公司ABL Bio Corporation（以下简称ABL Bio）今日宣布，双方针对多达八个抗体新药达成独家研发与临床生产战略合作。
根据合作协议，药明生物将为ABL Bio自有研发管线及其与天境生物的合作项目提供强有力支持。此次合作彰显了ABL Bio丰富的研发管线以及药明生物的双特异性抗体开发技术能力和强劲的产能实力。
“我们很高兴与药明生物达成独家战略合作，这将助力公司布局双特异性抗体等新一代生物创新药领域，推进公司自主研发及外部合作产品管线的开发。药明生物已成功赋能ABL Bio和天境生物，为多个临床前和临床项目提供开发和生产服务。”ABL Bio创始人兼首席执行官Sang Hoon Lee博士表示，“此次合作对ABL Bio而言意义非凡，一方面能积极拓展公司的双特异性抗体产品管线开发进程，另一方面将帮助我们跻身肿瘤免疫和神经退行性疾病领域拥有国际水平的公司之列。”
“这是我们首次与韩国合作伙伴建立独家战略合作协议，对此我感到非常荣幸。这再次证明药明生物作为开发和生产双特异抗体等高难度工艺生物药的全球行业领导者，其国际水准的技术实力已经获得广泛认可。”药明生物首席执行官陈智胜博士表示，“药明生物打造了全球最大规模的生物药研发团队之一，在近2000名经验丰富科学家的共同努力下，我们每年可以赋能客户将60个项目推至新药临床试验申请（IND）以及3个项目推向生物制品上市申请（BLA）。凭借全球合作伙伴认可的强大生物制药技术能力及全球首屈一指的产能规模，药明生物正在变革全球生物药开发和生产进程。”
关于ABL Bio
ABL Bio是一家成立于2016年的韩国生物技术公司，专注肿瘤免疫和神经退行性疾病的抗体疗法开发。成立三年以来，公司已顺利完成近1亿美元融资，目前正在筹备韩国证券交易所（KOSDAQ）公开上市事宜。公司在研产品ABL001，即靶向VEGF和DLL4的双特异肿瘤抗体，目前已进入一期临床试验。在神经退行性疾病领域，ABL Bio正利用其双特异抗体专长，开发旨在最大化提高血脑屏障穿透性和疗效的新一代产品。现阶段，公司研发进展最快的产品ABL301，是靶向α-突触核蛋白的双特异性抗体，可以通过受体介导的转胞吞作用穿透血脑屏障，用于治疗帕金森。ABL Bio已建立起强大的研发团队，在免疫肿瘤学治疗领域积极开展Best-in-Class及First-in-Class的双特异抗体开发工作。如需更多信息，请访问：www.ablbio.com。
关于药明生物
药明生物（股票代码：2269.HK）作为一家香港上市公司，是全球领先的开放式、一体化生物制药能力和技术赋能平台。公司为全球生物制药公司和生物技术公司提供全方位的端到端研发服务，帮助任何人、任何公司发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。截至2018年6月30日，在药明生物平台上研发的综合项目达187个，包括98个处于临床前研究阶段，78个在临床早期（I期，II期）阶段，10个在后期临床（III期）以及1个在商业化生产阶段。预计到2021年，公司在中国、爱尔兰、新加坡、美国规划的生物制药生产基地合计产能约22万升，这将有力确保公司通过健全强大的全球供应链网络为客户提供符合全球质量标准的生物药。如需更多信息，请访问：www.wuxibiologics.com.cn。
相关阅读
WuXi Biologics and ABL Bio Enter an Exclusive Development and Clinical Manufacturing Partnership for Multiple Bispecific Antibodies
SHANGHAI, China and SEOUL, South Korea
November 28, 2018
WuXi Biologics (2269.HK, WuXi Bio), a leading global open-access biologics technology platform company offering end-to-end solutions for biologics discovery, development and manufacturing, and ABL Bio Corporation (ABL Bio), a privately-held South Korean biotechnology company developing antibody therapeutics for immuno-oncology and neurodegenerative diseases, today announced that the companies have entered into an exclusive development and clinical manufacturing partnership for up to 8 antibody therapeutics including ABL Bio’s biologics pipelines and collaboration programs between ABL Bio and I-Mab Biopharma (I-Mab). The agreement showcases the expansive biologics pipeline of ABL Bio and the world leading technical expertise and capabilities of WuXi Biologics in developing bispecific programs.
“We are very pleased to enter into this partnership with WuXi Biologics. The partnership with WuXi Biologics is an important strategy for growing our internal and external programs of next-generation of biologics such as bispecific antibody. WuXi Biologics has enabled several preclinical and clinical manufacturing programs for ABL Bio as well as collaboration with I-Mab,” said Dr. Sang Hoon Lee, Chief Executive Officer of ABL Bio. “I believe that the partnership with WuXi Biologics will bring a synergy effect for developing our bispecific antibody pipelines and help us step up to be a global top-tier biotechnology company for immuno-oncology and neurodegenerative disease treatment.”
“We are excited about this exclusive partnership, our first in South Korea. WuXi Biologics has been well recognized as a global leader in the development and manufacturing of difficult biologics such as bispecific antibodies.This agreement continues to exemplify our technical strength and unparalleled capacity in global biologics development and manufacturing,” said Dr. Chris Chen, Chief Executive Officer of WuXi Biologics. “We are able to initiate 60 IND-enabling programs and 3 BLA-enabling programs per year, enabled by one of the largest biologics development teams in the industry of approximately 2000 scientists. With globally recognized technical capabilities and unparalleled capacities, we are transforming how biologics are developed in the global setting.”
About ABL Bio
ABL Bio is a privately-held South Korean biotechnology company developing antibody therapeutics for immuno-oncology and neurodegenerative disease. ABL Bio was founded in 2016 and successfully raised close to $ 100 million USD in less than 3 years and is currently preparing to IPO on the Korean stock exchange (KOSDAQ). ABL001, a bispecific antibody (BsAb) targeting VEGF and DLL4 is currently in Phase 1 clinical trial for oncology. In the neurodegenerative disorder space, ABL Bio is harnessing its BsAb expertise to develop next-generation BsAbs designed to maximize blood–brain barrier (BBB) penetrance and therapeutic efficacy. The most advanced molecule is ABL301, an α-synuclein-targeting BsAb that penetrates the BBB via a receptor-mediated transcytosis (RMT) and is in development for Parkinson’s disease (PD). ABL Bio is also actively developing immune-oncology therapies and has built strong R&D team to develop First-in-Class and Best-in-Class BsAbs. For more information, check out www.ablbio.com.
About WuXi Biologics
WuXi Biologics (stock code: 2269.HK), a Hong Kong-listed company, is the only open-access biologics technology platform in the world offering end-to-end solutions to empower organizations to discover, develop and manufacture biologics from concept to commercial manufacturing. Our company history and achievements demonstrate our commitment to providing a truly ONE-stop service offering and value proposition to our global clients. As of June 30, 2018, there were a total of 187 integrated projects, including 98 projects in pre-clinical development stage, 78 projects in early-phase (phase I and II) clinical development, 10 projects in late-phase (phase III) development and 1 project in commercial manufacturing. With total estimated capacity of biopharmaceutical production planned in China, Ireland, Singapore and US reaching 220,000 liters by 2021, we will provide our biomanufacturing partners with a robust and premier-quality global supply chain network. For more information on WuXi Biologics, please visit www.wuxibiologics.com.
注：本信息不构成药明生物的信息披露或投资建议
