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上海和瑞士洛桑，2018年12月19日
-借助药明生物自主开发的超高效连续生产工艺平台WuXiUP等在创新生物制品生产领域积累的丰富经验，AC Immune公司能够更好地开发中枢神经系统领域产品，降低生物药开发成本
-AC Immune公司获得授权使用药明生物WuXiBody™等多个拥有自主知识产权的生物制药技术平台，开发新一代双特异性抗体
-药明生物成为AC Immune公司生物工艺开发和生产首选合作伙伴，为其提供强有力支持
全球领先的开放式生物制药技术平台公司药明生物（WuXi Biologics, 2269.HK）与围绕神经退行性疾病建立丰富研发管线的瑞士临床阶段生物制药公司AC Immune SA（纳斯达克股票代码：ACIU，以下简称AC Immune）今日宣布，双方已针对生物药发现、开发及生产等领域达成独家战略合作。
通过此次独家战略合作，AC Immune公司将借助药明生物在传统和创新生物制品生产及供应领域的一流技术能力和强劲产能实力，更好地开发中枢神经系统领域产品，并获得授权使用药明生物多个拥有自主知识产权的生物制药技术平台，包括双特异性抗体开发技术平台WuXiBody™以及超高效连续细胞培养生产工艺平台WuXiUP。同时，药明生物将成为AC Immune公司生物工艺开发和生产首选合作伙伴，为其强劲产品管线的发现、临床前及临床试验样品供应提供有力支持。
根据该合作协议，双方还将充分利用AC Immune公司卓越的抗体发现技术平台开发候选药物服务全球企业，探索针对中枢神经系统以外疾病的创新生物药。与此同时，药明生物和海利生物合资成立的疫苗研发生产服务企业药明海德（WuXi Vaccines）也将赋能AC Immune公司疫苗产品线探索中国市场。
“我们很高兴与中国生物制药行业佼佼者药明生物达成独家战略合作。”AC Immune公司首席执行官Andrea Pfeifer教授表示，“AC Immune公司致力于成为全球神经退行性疾病精准医疗领域的领军者，为治疗阿尔兹海默症提供有效方案。在实现这一伟大愿景的过程中，中国市场及中国企业将发挥至关重要的作用。”
“AC Immune公司已经通过与基因泰克及礼来达成的合作，证明了其在中枢神经系统领域全球领先的地位，我们很兴奋能与AC Immune公司建立全面独家战略合作关系。中枢神经系统生物药的成功与否很大程度上依赖有竞争力的生产技术和较低的生产成本。药明生物拥有自主知识产权的双特异性抗体开发平台WuXiBody™和超高效连续细胞培养生产工艺平台WuXiUP不仅突破了同类技术平台的局限性，同时还具有显著降低开发和生产成本等优势，这都将有力推进合作项目的商业化进程。”药明生物首席执行官陈智胜博士表示，“我们将持续致力于投资开发全球领先的创新技术，加快和变革生物药开发和生产进程，赋能AC Immune公司这样优质的全球合作伙伴针对更多未被满足的临床需求提供高质量标准的创新生物药，造福全球患者。”
关于AC Immune SA
AC Immune SA是一家在纳斯达克上市的瑞士临床阶段生物制药公司，致力于成为全球神经退行性疾病精准医疗领域领军者。公司设计、发现并开发了一系列治疗和诊断产品用于预防以及修复由蛋白错误折叠导致的疾病。基于两个领先的专利技术平台，AC Immune SA公司针对以阿尔兹海默症为代表的多种神经退行性疾病开发了抗体、小分子药物和疫苗。公司产品线包括9个治疗产品和3个候选诊断产品，其中5个产品处于临床试验阶段。公司进展最快的产品crenezumab是一款抗β-淀粉样蛋白的全人源IgG4单克隆抗体，目前正处于两项治疗阿尔兹海默症的III期临床试验中，该产品与罗氏/基因泰克在全球范围展开了合作。公司合作伙伴还包括礼来、Biogen、杨森、雀巢健康科学、Life Molecular Imaging （前身为Piramal Imaging）和Essex Bio-Technology。如需更多信息，请访问：www.acimmune.com。
关于药明生物
药明生物（股票代码：2269.HK）作为一家香港上市公司，是全球领先的开放式、一体化生物制药能力和技术赋能平台。公司为全球生物制药公司和生物技术公司提供全方位的端到端研发服务，帮助任何人、任何公司发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。截至2018年6月30日，在药明生物平台上研发的综合项目达187个，包括98个处于临床前研究阶段，78个在临床早期（I期，II期）阶段，10个在后期临床（III期）以及1个在商业化生产阶段。预计到2021年，公司在中国、爱尔兰、新加坡、美国规划的生物制药生产基地合计产能约22万升，这将有力确保公司通过健全强大的全球供应链网络为客户提供符合全球质量标准的生物药。如需更多信息，请访问：www.wuxibiologics.com.cn。
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WuXi Biologics and AC Immune to Establish an Exclusive Strategic Partnership
SHANGHAI and LAUSANNE Switzerland
December 19, 2018
-AC Immune to draw on WuXi Biologics' expertise in manufacturing innovative New Biological Entities against CNS disorders including proprietary WuXiUP continuous manufacturing platform that can significantly reduce cost of biologics
-AC Immune to gain access to WuXi Biologics' proprietary discovery platforms including the WuXiBody™ Platform used for the generation of bispecific antibodies
-WuXi Biologics to become a preferred partner for bioprocess development and manufacturing
WuXi Biologics (2269.HK), a leading global open-access biologics technology platform company that offers end-to-end solutions for biologics discovery, development and manufacturing and AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company with a broad pipeline focused on neurodegenerative diseases, today announced the first steps of an exclusive strategic collaboration that covers biologics discovery, development and manufacturing.
AC Immune and WuXi Biologics have entered into a memorandum of understanding governing the terms of a preferred partnership allowing AC Immune to leverage WuXi Biologics' capacities and capabilities in the manufacturing and supply of traditional and innovative New Biological Entities (NBE) against disorders of the central nervous system (CNS). Through this collaboration, AC Immune would have priority access to WuXi Biologics' proprietary platforms, including the bispecific antibody platform WuXiBody™ and WuXiUP continuous manufacturing platform. In addition, WuXi Biologics would become a preferred partner of AC Immune for bioprocesss development, as well as manufacturing for discovery, pre-clinical and clinical supply of AC Immune's NBE pipeline.
Under the same agreement, the companies would explore the use of AC Immune's platform to treat non-CNS diseases by identifying areas where AC Immune's antibody discovery platform could generate superior novel candidates. In addition, WuXi Vaccines, the vaccine arm of WuXi Biologics, would explore enabling the application of AC Immune's vaccine portfolio in China.
Prof. Andrea Pfeifer, CEO of AC Immune SA, commented: "I am very happy to work with WuXi Biologics and proud to form the basis for a partnership with such an esteemed partner in China. AC Immune aims to become a global leader in precision medicine of neurodegenerative diseases and in getting closer to develop a therapy against Alzheimer's disease, in which China plays an important role."
Dr. Chris Chen, CEO of WuXi Biologics commented: "We are excited about finalizing this exclusive and comprehensive partnership and are pleased to enable AC Immune which has proven itself as a global leader in CNS diseases by partnering with Genentech and Lilly. Our comprehensive partnership would include discovery, development and manufacturing of multiple biologics and vaccine modalities including bispecific antibodies through our proprietary WuXiBody™ Platform. This platform coupled with WuXiUP tackles technical hurdles of conventional bispecific platforms and tremendously reduces the cost of making these biologics, which is critical for success of biologics in treating CNS disorders. We will continue to invest in developing next-generation globally leading technologies to enable global clients and transform biologics discovery, development and manufacturing. Together with global partners like AC Immune we are developing and manufacturing life-saving biologics to benefit patients around the world."
About AC Immune SA
AC Immune SA is a clinical-stage Swiss-based biopharmaceutical company, listed on NASDAQ, which aims to become a global leader in precision medicine for Neurodegenerative Diseases. The Company designs, discovers and develops therapeutic as well as diagnostic products intended to prevent and modify diseases caused by misfolding proteins. AC Immune's two proprietary technology platforms create antibodies, small molecules and vaccines designed to address a broad spectrum of neurodegenerative indications, such as Alzheimer’s disease (AD). The Company's pipeline features nine therapeutic and three diagnostic product candidates – with five product candidates currently in clinical trials. The most advanced of these is crenezumab, a humanized anti-beta-amyloid monoclonal IgG4 antibody that targets monomeric and aggregated forms of beta-amyloid, with highest affinity for neurotoxic oligomers. Crenezumab is currently in two Phase 3 clinical studies for AD, under a global program conducted by collaboration partner Roche/Genentech. Other collaborations include Eli Lilly, Biogen, Janssen Pharmaceuticals, Nestlé Institute of Health Sciences, Life Molecular Imaging (formerly Piramal Imaging) and Essex Bio-Technology. For more information on AC Immune SA, please visit www.acimmune.com.
About WuXi Biologics
WuXi Biologics (stock code: 2269.HK), a Hong Kong-listed company, is the only open-access biologics technology platform in the world offering end-to-end solutions to empower organizations to discover, develop and manufacture biologics from concept to commercial manufacturing. Our company history and achievements demonstrate our commitment to providing a truly ONE-stop service offering and value proposition to our global clients. As of June 30, 2018, there were a total of 187 integrated projects, including 98 projects in pre-clinical development stage, 78 projects in early-phase (phase I and II) clinical development, 10 projects in late-phase (phase III) development and 1 project in commercial manufacturing. With total estimated capacity of biopharmaceutical production planned in China, Ireland, Singapore and US reaching 220,000 liters by 2021, we will provide our biomanufacturing partners with a robust and premier-quality global supply chain network. For more information on WuXi Biologics, please visit www.wuxibiologics.com.
注：本信息不构成药明生物的信息披露或投资建议
