药明生物与腾盛博药针对全新双特异抗体免疫疗法达成独家研发合作
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上海，2018年12月10日
全球领先的开放式生物制药技术平台公司药明生物（WuXi Biologics, 2269.HK）今日宣布，与致力于满足中国患者及公共卫生需求的新锐生物技术公司腾盛博药（Brii Biosciences）针对治疗传染病及免疫疾病的全新双特异性抗体研发达成战略合作，并成为这些项目的独家工艺开发和生产合作伙伴，为腾盛博药提供强有力支持。
药明生物首席执行官陈智胜博士（左）和腾盛博药联合创始人兼首席执行官洪志博士（右）共同出席签约仪式
此次战略合作，将集双方之长进一步加快拓展腾盛博药的产品管线。根据合作协议，腾盛博药获授权使用包括WuXiBody™双抗平台在内的药明生物一体化生物制药技术赋能平台，在中国发现、开发与生产双特异性抗体。
“开发创新免疫调节剂来调控宿主免疫应答机制的研究目前在全球还处于萌芽阶段，有望推动传染病治疗领域的发展。”腾盛博药联合创始人兼首席执行官洪志博士表示，“药明生物具有世界领先的生物药发现、开发和生产技术实力，与这样优秀的生物技术平台型公司合作将赋能腾盛博药开发更多创新疗法，将我们对全新靶点的认识在中国转化为服务全球市场的关键性新疗法。”
“我们很高兴包括WuXiBody™在内的端到端抗体开发专利技术平台赋能腾盛博药，助力其进一步开发全新双特异性抗体。公司具有自主知识产权的双特异性抗体开发平台WuXiBody™不仅突破了同类技术平台的局限性，同时还具有显著降低双特异性抗体生产成本等优势。”药明生物首席执行官陈智胜博士表示，“我们希望赋能合作伙伴，为更多临床急需的治疗领域提供高质量标准的创新生物药，造福全球患者。”
关于WuXiBody™
WuXiBody™是药明生物具有自主知识产权的双特异性抗体技术平台，有望成为业界最好的双特异性抗体平台之一。该平台突破了绝大多数双特异性抗体平台技术瓶颈，有效克服了双特异性抗体开发过程中表达量低、多聚体高、纯化收率低等挑战，具有为每个项目节约6到18个月研发时间以及显著降低双特异性抗体生产成本等优势。目前已开发的双特异性抗体表达量最高达16g/L，并且达到一步Protein A纯化后纯度和收率均超过95%。同时，WuXiBody™平台还兼具独特的灵活性，可以构建各种不同的价数（如二价、三价或四价双特异性抗体）和结构，以满足不同项目的生物学特性需求。
关于药明生物
药明生物（股票代码：2269.HK）作为一家香港上市公司，是全球领先的开放式、一体化生物制药能力和技术赋能平台。公司为全球生物制药公司和生物技术公司提供全方位的端到端研发服务，帮助任何人、任何公司发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。截至2018年6月30日，在药明生物平台上研发的综合项目达187个，包括98个处于临床前研究阶段，78个在临床早期（I期，II期）阶段，10个在后期临床（III期）以及1个在商业化生产阶段。预计到2021年，公司在中国、爱尔兰、新加坡、美国规划的生物制药生产基地合计产能约22万升，这将有力确保公司通过健全强大的全球供应链网络为客户提供符合全球质量标准的生物药。如需更多信息，请访问：www.wuxibiologics.com.cn。
WuXi Biologics Announced Exclusive Discovery Research with Brii Biosciences for Novel Bispecific Antibody Immunotherapeutics
SHANGHAI, December 10, 2018
WuXi Biologics (2269.HK), a leading global open-access biologics technology platform company offering end-to-end solutions for biologics discovery, development and manufacturing, announced today a strategic collaboration with Brii Biosciences (Brii Bio), an innovative biotechnology company operates in China and the US, focusing on accelerating innovation and optimizing access to serve the need of Chinese patients and public health, to discover and develop bispecific antibodies to treat infectious diseases and other immunologic disorders.
Dr. Chris Chen, Chief Executive Officer of WuXi Biologics (left) and Dr. Zhi Hong, Co-founder and Chief Executive Officer of Brii Biosciences (right) attended the signing ceremony
This collaboration will further integrate the advantages of the two companies and expedite the development of Brii Bio's pipeline. Under the terms of the exclusive research agreement, Brii Bio has the access to WuXi Biologics' entire antibody platform capabilities including the WuXiBody™ technology to discover novel bispecific antibodies. WuXi Biologics will also be the exclusive development and manufacturing partner of any novel bispecific antibodies discovered from the WuXiBody™ Platform.
"Discovery of novel immunotherapeutics modulating the host immune responses represents an untapped paradigm that may improve the treatment of infectious diseases," said Dr. Zhi Hong, Co-founder and Chief Executive Officer of Brii Biosciences, "WuXi Biologics has successfully grown and expanded its capability and capacity in biopharmaceutical, which will enable us to translate target insight to key therapeutic modalities and innovate in China for the world."
"We are pleased to enable Brii Bio in developing and manufacturing bispecific therapeutics through the proprietary WuXiBody™ Platform that tackles technical hurdles of bispecific platforms and tremendously reduces the cost of making these biologics, therefore offer novel treatments for unmet medical needs," said Dr. Chris Chen, Chief Executive Officer of WuXi Biologics. "The collaboration is expected to develop and manufacture life-saving biologics targeting different diseases, and then benefit patients around the world."
About WuXiBody™
WuXiBody™, a proprietary bispecific antibody platform of WuXi Biologics, is potentially the Best-in-Class bispecific platform in the field. It can effectively break through the CMC barriers of bispecific antibodies development, expedite the process by 6-18 months and significantly reduce manufacturing cost, a severe limitation of other current bispecific platforms. WuXiBody™ bispecifics have achieved 16g/L in cell culture titer, 95+% purity after one-step Protein A purification and 95+% yield for Protein A step. WuXiBody™ Platform enables almost any mAb sequence pairs to be assembled into bispecific constructs. They are characterized as low immunogencity, long in vivo half-life like mAbs and excellent stability. WuXiBody™ Platform also owns its unique structural flexibility, which makes it convenient to build various formats with different valency (2, 3 or 4 binding sites) to meet the requirements of different bispecific targets.
About WuXi Biologics
WuXi Biologics (stock code: 2269.HK), a Hong Kong-listed company, is the only open-access biologics technology platform in the world offering end-to-end solutions to empower organizations to discover, develop and manufacture biologics from concept to commercial manufacturing. Our company history and achievements demonstrate our commitment to providing a truly ONE-stop service offering and value proposition to our global clients. As of June 30, 2018, there were a total of 187 integrated projects, including 98 projects in pre-clinical development stage, 78 projects in early-phase (phase I and II) clinical development, 10 projects in late-phase (phase III) development and 1 project in commercial manufacturing. With total estimated capacity of biopharmaceutical production planned in China, Ireland, Singapore and US reaching 220,000 liters by 2021, we will provide our biomanufacturing partners with a robust and premier-quality global supply chain network. For more information on WuXi Biologics, please visit www.wuxibiologics.com.
注：本信息不构成药明生物的信息披露或投资建议
