独家授权| 药明生物赋能Exelixis扩充肿瘤生物药管线

中国上海和美国加利福尼亚州阿拉米达

2021年3月8日

全球领先的开放式生物制药技术平台公司药明生物（WuXi Biologics, 2269.HK）与Exelixis（纳斯达克股票代码：EXEL）今日宣布达成独家授权协议，药明生物将进一步支持Exelixis扩充肿瘤生物药管线。今年1月，Exelixis商业化产品CABOMETYX®（cabozantinib）获得美国食品药品监督管理局（FDA）批准第四个适应症。此次与药明生物达成的独家授权协议是Exelixis持续扩充生物药管线新的里程碑。 

根据协议，在药明生物一体化技术平台的赋能下，Exelixis将获得多个针对肿瘤适应症的单克隆抗体独家权益，并能够针对该已验证的靶点研发单克隆抗体、抗体偶联药物（ADC）、双特异性抗体以及其他针对癌症适应症的生物药。药明生物将获得一笔首付款，并根据后续研发和商业化进程获得潜在里程碑付款和净销售提成。

Exelixis, Inc.（纳斯达克股票代码：EXEL）成立于1994年，是一家新药产品已经成功商业化，专注于肿瘤学的生物技术公司，致力于加速难治性癌症新药的发现，开发和商业化。基于模型系统遗传学的早期工作，公司建立了广泛的药物发现和开发平台，为患者提供新型癌症治疗方法奠定了基础。公司目前拥有四款上市销售产品，CABOMETYX® (cabozantinib)，COMETRIQ® (cabozantinib)，COTELLIC® (cobimetinib)和MINNEBRO® (esaxerenone)，并且与世界领先的制药公司建立了合作伙伴关系，为全球患者提供这些产品。在上市产品和广泛合作的支持下，Exelixis谨慎地对业务进行再投资，以最大程度地优化产品管线的价值。通过针对性的外部业务拓展和内部药物发现，Exelixis不断丰富其现有产品管线，提供新一代药物造福广大患者。Exelixis是标准普尔（S＆P）MidCap 400指数成员，该指数用于衡量盈利的中型公司业绩。2020年11月，公司首次入选《财富》杂志评选的100家最快成长的公司榜单，并排名第17位，在生物制药公司中位列第三。如需了解Exelixis更多信息，请访问www.exelixis.com，Twitter上请关注@ExelixisInc，Facebook请关注Exelixis, Inc.。

药明生物（股票代码：2269.HK）作为一家香港上市公司，是全球领先的开放式、一体化生物制药能力和技术赋能平台。公司为全球生物制药公司和生物技术公司提供全方位的端到端研发服务，帮助任何人、任何公司发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。截至2020年6月30日，在药明生物平台上研发的综合项目达286个，包括141个处于临床前研究阶段，125个在临床早期（I期，II期）阶段，19个在后期临床（III期）以及1个在商业化生产阶段。预计到2023年后，公司在中国、爱尔兰、美国、德国和新加坡规划的生物制药生产基地合计产能将超过30万升，这将有力确保公司通过健全强大的全球供应链网络为客户提供符合全球质量标准的生物药。如需更多信息，请访问：www.wuxibiologics.com。

SHANGHAI and ALAMEDA, Calif.

March 8, 2021 

WuXi Biologics (“WuXi Bio”) (2269.HK), a global company with leading open-access biologics technology platforms, and Exelixis, Inc. (Nasdaq: EXEL) today announced the companies have entered into an exclusive license agreement to support the continued expansion of Exelixis' oncology biologics pipeline. The agreement is the latest in a series of biologics-focused transactions for Exelixis as the company builds out its pipeline behind CABOMETYX® (cabozantinib), its flagship product and global oncology franchise, which received its fourth approval from the U.S. Food and Drug Administration in January.

Under the terms of the agreement, Exelixis will make a modest upfront payment to WuXi Bio in exchange for an exclusive license to a panel of monoclonal antibodies to a preclinically validated target, discovered based on WuXi Biologics integrated technology platforms, for the development of antibody-drug conjugate, bispecific, and certain other novel tumor-targeting biologics applications. WuXi Bio will be eligible for development and commercialization milestones, as well as tiered royalties on net sales of any potential products commercialized from the panel.

Founded in 1994, Exelixis, Inc. (Nasdaq: EXEL) is a commercially successful, oncology-focused biotechnology company that strives to accelerate the discovery, development and commercialization of new medicines for difficult-to-treat cancers. Following early work in model system genetics, we established a broad drug discovery and development platform that has served as the foundation for our continued efforts to bring new cancer therapies to patients in need. Our discovery efforts have resulted in four commercially available products, CABOMETYX® (cabozantinib), COMETRIQ® (cabozantinib), COTELLIC® (cobimetinib) and MINNEBRO® (esaxerenone), and we have entered into partnerships with leading pharmaceutical companies to bring these important medicines to patients worldwide. Supported by revenues from our marketed products and collaborations, we are committed to prudently reinvesting in our business to maximize the potential of our pipeline. We are supplementing our existing therapeutic assets with targeted business development activities and internal drug discovery — all to deliver the next generation of Exelixis medicines and help patients recover stronger and live longer. Exelixis is a member of the Standard & Poor's (S&P) MidCap 400 index, which measures the performance of profitable mid-sized companies. In November 2020, the company was named to Fortune's 100 Fastest-Growing Companies list for the first time, ranking 17th overall and the third-highest biopharmaceutical company. For more information about Exelixis, please visit www.exelixis.com, follow @ExelixisInc on Twitter or like Exelixis, Inc. on Facebook.

WuXi Biologics (stock code: 2269.HK), a Hong Kong-listed company, is a leading global open-access biologics technology platform offering end-to-end solutions to empower organizations to discover, develop, and manufacture biologics from concept to commercial manufacturing. The company's history and achievements demonstrate its commitment to providing a truly one-stop service offering and strong value proposition to its global clients. As of June 30, 2020, there were a total of 286 integrated projects, including 141 projects in pre-clinical development stage, 125 projects in early-phase (phase I and II) clinical development, 19 projects in late-phase (phase III) development and one project in commercial manufacturing. With total estimated capacity for biopharmaceutical production planned in China, Ireland, the U.S., Germany, and Singapore exceeding 300,000 liters after 2023, WuXi Biologics will provide its biomanufacturing partners with a robust and premier-quality global supply chain network. For more information about WuXi Biologics, please visit: www.wuxibiologics.com.