药明生物与GSK就多款创新TCE双抗/多抗达成许可协议

中国，上海

2023年1月5日

全球领先的合同研究、开发和生产（CRDMO）服务公司药明生物（WuXi Biologics, 2269.HK）宣布与葛兰素史克（LSE/NYSE: GSK）达成许可协议，GSK将获得基于药明生物专利技术平台开发的至多四款TCE双特异性/多特异性抗体的独家权利。

根据协议，GSK将获得一款处于临床前阶段的双特异性抗体和其他至多三款处于早期发现阶段的TCE抗体的全球独家研究、开发、生产和商业化权利。该款双抗分别靶向肿瘤细胞表面的肿瘤相关抗原（TAA）和T细胞表面抗原CD3，通过与肿瘤细胞及T细胞结合，特异性激活T细胞，从而杀伤肿瘤细胞，产生抗肿瘤活性。药明生物将获得4000万美元首付款和最高达14.6亿美元的四款TCE抗体的研究、开发、注册和商业化里程碑付款。药明生物也有资格获得基于净销售额的分级销售提成。

此次与GSK达成许可协议不仅再次证明了药明生物潜在同类最优（Best-in-Class）的CD3抗体技术平台和领先的双抗技术平台WuXiBody^®，也凸显了公司独特CRDMO商业模式中‘R’（研究服务）的优势。这一合作也体现了我们以强大执行力为支点，为全球客户提供高质量开放式生物技术平台所做出的不懈努力。我们期待赋能GSK早日将这些潜力疗法惠及病患，为更多全球患者带来新的治疗希望。

此次与药明生物达成许可协议将为GSK引进潜在同类最优（Best-in-Class）的TCE抗体，进一步扩充公司肿瘤靶向药物产品组合。这些优化后的抗体不仅表现出强大的抗肿瘤疗效，还具有卓越的安全性，有望满足巨大的未满足医疗需求，为多个癌种的肿瘤患者提供潜在治疗方案。

WuXi Biologics and GSK Enter into License Agreement on Multiple Novel Bi- & Multi-specific T Cell Engagers

Shanghai, China 

January 5, 2023 

WuXi Biologics ("WuXi Bio") (2269. HK), a leading global Contract Research, Development, and Manufacturing Organization (CRDMO), today announced a license agreement with GSK plc (LSE/NYSE: GSK) under which GSK will have exclusive licenses for up to four bi- & multi-specific TCE antibodies developed using WuXi Biologics' proprietary technology platforms.

Under the terms of the agreement, GSK will be granted an exclusive global license for the research, development, manufacturing, and commercialization of a pre-clinical bispecific antibody that crosslinks tumor cells and T cells by targeting a tumor-associated antigen (TAA) on tumor cells and CD3 expression on T cells and up to three additional pre-clinical TCE antibodies currently at an earlier discovery stage. WuXi Biologics will receive a $40 million upfront payment and up to $1.46 billion in additional payments for research, development, regulatory and commercial milestones across the four TCE antibodies. WuXi Biologics is also eligible to receive tiered royalties on net sales.

This license agreement with GSK represents an important validation of our potential best-in-class CD3 platform and WuXiBody^® platform, the 'R' in our CRDMO business model. This also demonstrates our efforts in offering global open-access technology platforms with premier quality and excellent execution. We are looking forward to enabling GSK to bring these potentially life-saving therapeutics to more patients worldwide. 

This agreement with WuXi Biologics builds on our oncology portfolio of tumor cell targeting agents by providing GSK with access to potential best-in-class T-cell engaging antibodies that have been optimized for effective tumor killing with a desirable safety profile, offering the potential to address significant unmet medical need in patients with multiple tumor types.