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WuXiaADCC PLUSTM旨在生产高ADCC（抗体依赖性细胞介导的细胞毒性）活性的无岩藻糖基化抗体，满足提高治疗效果的市场需求，为全球客户提供多样化选择
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WuXiaADCC PLUSTM由药明生物细胞株构建技术平台WuXiaTM拓展而来，WuXiaTM开发的细胞株已通过监管机构认证
上海,
2024年1月25日
全球领先的合同研究、开发和生产（CRDMO）服务公司药明生物（WuXi Biologics, 2269.HK）宣布推出全新哺乳动物细胞株构建技术平台WuXiaADCC PLUSTM。该平台为高效、高产量、高ADCC活性的无岩藻糖基化抗体开发和生产平台（详见图1）。
业界普遍认为ADCC在基于靶向抗体的免疫疗法中发挥着关键作用。目前新型癌症疗法开发的方向之一就是通过抗体设计和工程化改造增强ADCC效应，从而提升患者临床治疗效果。
图1：实验数据证明，与对照组相比，WuXiaADCC PLUSTM平台表达的抗体的ADCC活性显著提高
去除N糖基化位点上的岩藻糖修饰来增强ADCC效应，是提高抗体免疫疗法疗效的一种经济且高效的方法。为了满足全球客户日益增长的表达无岩藻糖基化抗体的需求，药明生物在经过高度验证的细胞株构建平台WuXiaTM的基础上，进一步打造了WuXiaADCC PLUSTM。该技术平台不仅与WuXiaTM细胞株平台工艺兼容，还能够稳定表达高ADCC活性的无岩藻糖基化抗体，用于不同规模的临床和商业化生产。
陈智胜
博士
药明生物首席执行官
我们很高兴推出全新细胞株技术平台WuXiaADCC PLUSTM，为全球客户研发创新抗体疗法提供新型生物工艺解决方案。长期以来，药明生物不断推陈出新，持续打造创新技术平台，突破业界技术瓶颈，促进生物药开发和生产的技术进步与变革，这一切都是为了更好地赋能全球合作伙伴，让全球患者用得到、用得起更多高质量生物药。
关于WuXiaTM细胞株构建平台
WuXiaTM是药明生物开发的高产哺乳动物细胞株构建平台，产量最高达11g/L。该技术平台已获得全球药品监管机构的认可，开发了超过800个表达单克隆抗体、双特异性抗体、融合蛋白、酶和其他重组蛋白的细胞株，用于临床和商业化生产。
如需更多信息，请浏览：www.wuxibiologics.com/mammalian/cell-line-development/。
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关于药明生物
药明生物（股票代码：2269.HK）是一家全球领先的合同研究、开发和生产（CRDMO）服务公司。公司通过开放式、一体化生物制药能力和技术赋能平台，提供全方位的端到端服务，帮助合作伙伴发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。
药明生物在中国、美国、爱尔兰、德国和新加坡拥有超过12000名员工。通过药明生物人的专业服务团队，以及先进技术和精深洞见，公司为客户提供高效经济的生物药解决方案。截至2023年12月底，药明生物帮助客户研发和生产的综合项目高达698个，其中包括24个商业化生产项目。
药明生物将环境、社会和治理（ESG）视为业务发展和企业精神的重要组成部分，并致力于成为全球生物药CRDMO领域的ESG领导者，例如应用更绿色环保的新一代生物制药技术和能源等引领行业发展。公司成立了由首席执行官领导的ESG委员会，全面落实ESG战略并践行可持续性发展承诺。
更多信息，请访问：www.wuxibiologics.com
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WuXi Biologics Launches WuXiaADCC PLUSTM for the Development and Manufacturing of Afucosylated Antibodies that Elicit Enhanced ADCC Effect
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WuXiaADCC PLUSTM is designed to meet the market need for improved antibody therapeutic efficacy by producing afucosylated antibodies with the ability to increase antibody-dependent cell-mediated cytotoxicity (ADCC), providing diverse bioprocessing solutions for global clients
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WuXiaADCC PLUSTM is derived from WuXi Biologics' highly-vetted WuXiaTM cell line platform
Shanghai,
January 25, 2024
WuXi Biologics ("WuXi Bio") (2269.HK), a leading global Contract Research, Development, and Manufacturing Organization (CRDMO), today announced that it has launched WuXiaADCC PLUSTM, a superior-performing and high-yielding mammalian cell line platform for the development and manufacturing of afucosylated antibodies to elicit an enhanced ADCC response (Figure 1).
ADCC is recognized as a crucial mechanism underlying targeted antibody-based immunotherapy approaches. The development of novel cancer therapies entails designing and engineering antibodies with increased ability to heighten the ADCC response, which is known to improve therapeutic efficacy and patient outcomes.
Figure 1: Demonstration that an afucosylated antibody produced from the WuXiaADCC PLUSTM cell line exhibits significantly enhanced ADCC activity
Removal of fucose on the N-glycosylation site is an efficient and cost-effective way to enhance ADCC activity and increase the potency of antibody-based immunotherapies. To meet growing global demand for the production of afucosylated antibodies, the WuXiaADCC PLUSTM cell line was derived from the WuXi Biologics' highly-vetted WuXiaTM cell line. The WuXiaADCC PLUSTM cell line is compatible with the WuXiaTM platform process, which enables the stable production of the afucosylated antibodies at various scales for clinical and commercial manufacturing.
Dr. Chris Chen
CEO
WuXi Biologics
We are pleased to launch WuXiaADCC PLUSTM to provide a new bioprocessing solution for our global clients developing novel antibody therapies. WuXi Biologics’ continual launch of new technology platforms comes from our drive to push boundaries and foster innovation – all with the goal of enabling our global partners to bring more high-quality and affordable biologics to patients worldwide.
About the WuXia™ Cell Line
Development Platform
WuXiaTM is a proven, high-yielding (up to about 11 g/L) mammalian cell line platform developed by WuXi Biologics. Accepted by regulatory agencies worldwide, the WuXiaTM platform has generated over 800 cell lines expressing monoclonal and bispecific antibodies, fusion proteins, enzymes and other recombinant proteins for clinical and commercial manufacturing.
For more information about WuXiaTM, please visit: www.wuxibiologics.com/mammalian/cell-line-development/.
About
WuXi Biologics
WuXi Biologics (stock code: 2269.HK) is a leading global Contract Research, Development and Manufacturing Organization (CRDMO) offering end-to-end solutions that enable partners to discover, develop and manufacture biologics – from concept to commercialization – for the benefit of patients worldwide.
With over 12,000 skilled employees in China, the United States, Ireland, Germany and Singapore, WuXi Biologics leverages its technologies and expertise to provide customers with efficient and cost-effective biologics discovery, development and manufacturing solutions. As of December 31, 2023, WuXi Biologics is supporting 698 integrated client projects, including 24 in commercial manufacturing.
WuXi Biologics views Environmental, Social, and Governance (ESG) responsibilities as an integral component of our ethos and business strategy, and we aim to become an ESG leader in the biologics CRDMO sector. Our facilities use next-generation biomanufacturing technologies and clean-energy sources. We have also established an ESG committee led by our CEO to steer the comprehensive ESG strategy and its implementation, enhancing our commitment to sustainability.
For more information about WuXi Biologics, please visit: www.wuxibiologics.com.
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注：本信息不构成药明生物的信息披露或投资建议
