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2024年10月28日
全球领先的合同研究、开发和生产（CRDMO）服务公司药明生物（WuXi Biologics, 2269.HK）宣布推出基于高产量谷氨酰胺合成酶（GS）的中国仓鼠卵巢（CHO）表达系统WuXia™ RidGS细胞株构建平台。该平台为非抗生素筛选细胞株的研发平台，利用锌指核酸酶（ZFN）技术，敲除CHO细胞中的内源性GS基因。
WuXia™ RidGS衍生自WuXia™细胞株构建平台，并继承了WuXia™强大的细胞生长、代谢和表达水平。其单克隆抗体产品的平均克隆表达水平超过6 g/L，同时，WuXia™ RidGS能够确保单克隆抗体、双特异性抗体、融合蛋白和重组蛋白等多种疗法类型的细胞株稳定性。此外，该技术平台所表达的蛋白产品质量拥有良好的糖基化修饰水平，同时保持了极高的纯度。值得一提的是，在不使用抗生素情况下，WuXia™ RidGS宿主细胞和生产细胞在长期细胞传代中，始终保持稳定的产物表达量及产品质量。
陈智胜
博士
药明生物首席执行官
我们很高兴推出WuXia™ RidGS技术平台，为先进的治疗性蛋白产品的开发提供更高效的解决方案。为满足全球客户的多元化需求，药明生物矢志不渝地构建定制化的自主研发技术平台。我们赋能全球合作伙伴，加快创新药的研发，让全球患者能够用上更多、更具有可及性的高质量生物药。
关于WuXia™细胞株构建系列平台
WuXia™是药明生物开发的高产哺乳动物细胞株构建平台，产量最高达11g/L。该技术平台已获得全球药品监管机构的认可，开发了超过900个表达单克隆抗体、双特异性抗体、融合蛋白、酶和其他重组蛋白的细胞株，用于临床和商业化生产。在WuXia™卓越特性的基础上，WuXiaADCC Plus™【推荐阅读：药明生物推出全新细胞株平台WuXiaADCC Plus™赋能合作伙伴研发生产高ADCC活性无岩藻糖基化抗体】和WuXia™ RidGS积极满足全球客户的多元化需求。
关于药明生物
药明生物（股票代码：2269.HK）是一家全球领先的合同研究、开发和生产（CRDMO）公司。公司通过开放式、一体化生物制药能力和技术赋能平台，提供全方位的端到端服务，帮助合作伙伴发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。
药明生物在中国、美国、爱尔兰、德国和新加坡拥有超过12000名员工。通过药明生物的专业服务团队，以及先进技术和精深洞见，公司为客户提供高效经济的生物药解决方案。截至2024年6月底，药明生物帮助客户研发和生产的综合项目高达742个，其中包括16个商业化生产项目（不包括新冠项目和非活跃项目）。
药明生物将环境、社会和治理（ESG）视为业务发展和企业精神的重要组成部分，并致力于成为全球生物药CRDMO领域的ESG领导者，例如应用更绿色环保的新一代生物制药技术和能源等引领行业发展。公司成立了由首席执行官领导的ESG委员会，全面落实ESG战略并践行可持续性发展承诺。更多信息，请访问：www.wuxibiologics.com。
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WuXi Biologics Launches WuXia™ RidGS for Non-Antibiotic Cell Line Development
Shanghai,
October 28, 2024
WuXi Biologics ("WuXi Bio") (2269.HK), a leading global Contract Research, Development, and Manufacturing Organization (CRDMO), today announced the launch of WuXia™ RidGS, a high-yield glutamine synthetase (GS)-knockout Chinese hamster ovary (CHO) expression system platform. The platform, specialized in non-antibiotic cell line development, employs zinc finger nucleases (ZFN) technology for targeted knockout of the endogenous GS gene in CHO cells.
Based on the WuXia™ platform, WuXia™ RidGS not only retains the robust cell growth, metabolism, and expression profile characteristic of WuXia™, but also boasts an average clonal expression level exceeding 6 g/L for monoclonal antibodies(mAbs). WuXia™ RidGS ensures cell line stability for mAbs, as well as for various other therapeutic modalities, including bispecific antibodies, Fc-fusion proteins, and recombinant proteins. The quality of protein products expressed by the platform showcases favorable glycosylation patterns while maintaining an exceptional purity profile. In addition, without the need for antibiotics, WuXia™ RidGS host and production cells consistently maintain stable productivity and uniform product quality throughout extensive, long-term cell line stability studies.
Dr. Chris Chen
Chief Executive Officer
WuXi Biologics
With the launch of WuXia™ RidGS, we are pleased to offer a more efficient alternative for the development of advanced therapeutic proteins. WuXi Biologics continues its commitment to developing tailored technology platforms that cater to the evolving needs of our global clients, accelerating the speed to market for life-saving therapies and advancing the accessibility of high-quality biologics for patients worldwide.
About the WuXia™ Cell Line Development Platform Family
WuXia™ is a proven, high-yielding (up to about 11 g/L) mammalian cell line platform developed by WuXi Biologics. Accepted by regulatory agencies worldwide, the WuXia™ platform has generated over 900 cell lines expressing monoclonal and bispecific antibodies, fusion proteins, enzymes and other recombinant proteins for clinical and commercial manufacturing. WuXiaADCC Plus™ and WuXia™ RidGS mirror the impressive attributes of WuXia™, while catering to the diverse needs of global customers.
About
WuXi Biologics
WuXi Biologics (stock code: 2269.HK) is a leading global Contract Research, Development and Manufacturing Organization (CRDMO) offering end-to-end solutions that enable partners to discover, develop and manufacture biologics – from concept to commercialization – for the benefit of patients worldwide.
With over 12,000 skilled employees in China, the United States, Ireland, Germany and Singapore, WuXi Biologics leverages its technologies and expertise to provide customers with efficient and cost-effective biologics discovery, development and manufacturing solutions. As of June 30, 2024, WuXi Biologics is supporting 742 integrated client projects, including 16 in commercial manufacturing (excluding COVID CMO and non-COVID dormant CMO projects).
WuXi Biologics views Environmental, Social, and Governance (ESG) responsibilities a an integral component of our ethos and business strategy, and we aim to become an ESG leader in the biologics CRDMO sector. Our facilities use next-generation biomanufacturing technologies and clean-energy sources. We have also established an ESG committee led by our CEO to steer the comprehensive ESG strategy and its implementation, enhancing our commitment to sustainability.
For more information about WuXi Biologics, please visit: www.wuxibiologics.com
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注：本信息不构成药明生物的信息披露或投资建议
