2025年11月国内外泌体领域研究进展

11月份国内新出的细胞外囊泡/外泌体领域论文不完全统计有445篇。IF>10的有88篇；IF>20的有7篇。本期主要内容包括：免疫治疗、骨关节炎、癌症、间充质干细胞、纳米递送、代谢调控、炎症、化疗耐药、生物标志物、工程化改造、自噬、单囊泡分析等方面内容。

1.南京大学毕艳教授、李靓教授：脂肪细胞胞外囊泡调节中枢瘦素敏感性和能量稳态

Wang, J., et al. (2025). "Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis." 

Cell Metab. IF=30.9

2.安徽省第二人民医院医学检验中心：LDHA的Y10磷酸化促进细胞外囊泡来源的circSEPT9释放，通过调节miR - 515 - 5p/KIAA1429轴增强三阴性乳腺癌细胞的化疗耐药性

Wang, Y., et al. (2025). "Y10 phosphorylation of LDHA promotes the release of extracellular vesicle-derived circSEPT9 to enhance the chemoresistance of triple negative breast cancer cells via modulation of miR-515-5p/KIAA1429 axis." 

Drug Resist Updat 84: 101324. IF=21.7

3.国家纳米科学中心陈春英院士团队：佐剂-金属离子螯合的PTEN mRNA与细胞膜包被相结合，可增强免疫敏感性，实现精准癌症免疫治疗

Guo, M., et al. (2025). "Adjuvant-metal-ion-chelating PTEN mRNA with cell-membrane-coating augments the immune sensitivity for precise cancer immunotherapy." 

Sci Bull (Beijing).IF=21.1

4.第四军医大学西京医院杨柳/郑超、上海交通大学医学院附属瑞金医院崔文国团队：基于孟德尔随机化宏观分析、负载可编程全细胞外泌体样纳米囊泡（WELNs）的可注射微凝胶通过恢复昼夜节律来缓解骨关节炎

Yan, R., et al. (2026). "Injectable microgels loaded with programmable WELNs based on mendelian randomization macroanalysis alleviate osteoarthritis by restoring the circadian rhythm." 

Bioact Mater 56: 483-508. IF=20.3

5.南华大学附属第一医院晏怡果、薛静波、李学林：负载CAP - CD56(+)CD271(+)骨髓间充质干细胞外泌体的PVA/SA缓释水凝胶可减轻软骨细胞衰老并改善腰椎小关节骨关节炎

Xie, Y., et al. (2026). "CAP-CD56(+)CD271(+) BMSCs exos-loaded PVA/SA sustained-release hydrogel attenuates chondrocyte senescence and ameliorates lumbar facet joint osteoarthritis." 

Bioact Mater 57: 73-92. IF=20.3

6.中山大学生物医学工程学院张超、深圳市药品检验研究院王书晗：包封间充质干细胞外泌体和沸石咪唑酯骨架材料-8的水凝胶支架通过协调成骨和免疫调节促进骨再生

Si, Y., et al. (2025). "Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation." 

Bioact Mater 54: 329-351. IF=20.3

7.南方医科大学齐向东团队：人脐带间充质干细胞来源的三维外泌体联合透明质酸甲酯微针治疗深二度烧伤的机制研究

Elakkawi, M. M. J., et al. (2026). "Study on the mechanism of hUCMSCs-derived 3D exosome combined with HAMA microneedles in the treatment of deep second-degree burns." 

Bioact Mater 56: 468-482. IF=20.3

8.哈尔滨工业大学的韩晓军团队：构建具有尿素循环途径的人工细胞用于氨解毒

Ren, T., et al. (2025). "Construction of Artificial Cells with Urea Cycle Pathway for Ammonia Detoxification." 

Angew Chem Int Ed Engl: e16955. IF=17

9.苏州大学许方、苏州大学汪超、南京中医药大学孙东东：工程化树突状细胞衍生囊泡用于靶向T细胞的镁递送和代谢重编程

Yu, X., et al. (2025). "Engineered Dendritic Cell-Derived Vesicles for T-Cell-Targeted Magnesium Delivery and Metabolic Reprogramming." 

ACS Nano. IF=16.1

10.重庆医科大学附属第一医院廖军义：干扰素-γ诱导的间充质干细胞外泌体通过热休克蛋白70减轻软骨细胞衰老和骨关节炎进展

Liu, S., et al. (2025). "Interferon-γ-Induced Mesenchymal Stem Cell Exosomes Attenuate Chondrocyte Senescence and Osteoarthritis Progression by Hsp70." 

ACS Nano. IF=16.1

11.南方医科大学基础医学院余潇团队：TBK1的棕榈酰化增强了I型干扰素信号传导，并增强了小鼠的抗疟疾免疫力

Han, Z., et al. (2025). "Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice." 

Nat Commun 16(1): 10109. IF=15.7

12.苏州大学附属第一医院血液科田孝鹏：工程化大肠杆菌Nissle 1917靶向递送细胞外PD - L1 - mFc片段用于治疗炎症性肠病

Wang, Y., et al. (2025). "Engineered Escherichia coli Nissle 1917 targeted delivery of extracellular PD-L1-mFc fragment for treating inflammatory bowel disease." 

Acta Pharm Sin B 15(11): 6019-6033. IF=14.6

13.上海中医药大学冯年平/张永太教授团队：微针辅助的马齿苋来源纳米囊泡通过调节巨噬细胞M1/M2极化以及抑制NF-κB和STING信号通路改善特应性皮炎

Long, M., et al. (2025). "Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways." 

Acta Pharm Sin B 15(11): 5966-5987. IF=14.6

14.【综述】南京中医药大学王若宁/狄留庆团队：工程化植物细胞外囊泡，用于联合癌症免疫治疗的新兴纳米平台

Chen, F., et al. (2025). "Engineered plant extracellular vesicles: Emerging nanoplatforms for combinational cancer immunotherapy." 

Acta Pharm Sin B 15(11): 5663-5701. IF=14.6

15.生命科学学院唐艺芝：鉴定外膜囊泡为介导弯曲杆菌中抗生素耐药基因转移的新载体

Zhao, M., et al. (2025). "Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter." 

J Extracell Vesicles 14(11): e70195. IF=14.5

16.【综述】北京清华大学尹航教授团队牵头，联合海内外学者：揭示异质性，用于临床转化的单囊泡分析的创新与挑战

Zhang, Y., et al. (2025). "Unveiling Heterogeneity: Innovations and Challenges in Single-Vesicle Analysis for Clinical Translation." 

J Extracell Vesicles 14(12): e70209. IF=14.5

17.中国药科大学梁宏伟教授：足细胞来源的细胞外囊泡中的CKAP4可作为糖尿病肾病的非侵入性诊断生物标志物，并促进血管钙化

Zhang, H., et al. (2025). "CKAP4 in Extracellular Vesicle-Derived From Podocyte Serves as a Non-Invasive Diagnostic Biomarker for Diabetic Nephropathy and Promotes Vascular Calcification." 

J Extracell Vesicles 14(12): e70208. IF=14.5

18.西南医科大学附属中医医院汪国友：USP5负载的细胞外囊泡与E2F1稳定在椎间盘修复中的作用，关于衰老、特异性和内体逃逸的未解问题

Yang, D., et al. (2025). "USP5-Laden ApoEVs and E2F1 Stabilization in Disc Repair: Unresolved Questions on Senescence, Specificity and Endosomal Escape." 

J Extracell Vesicles 14(11): e70196. IF=14.5

19.福建医科大学附属协和医院陈昭阳：通过细胞纳米穿孔技术高效扩大EV-AAV生产用于家族性高胆固醇血症治疗

Yan, Y., et al. (2025). "Efficient Scaling up EV-AAVs Production via Cellular Nanoporation for Familial Hypercholesterolaemia Therapy." 

J Extracell Vesicles 14(11): e70186. IF=14.5

20.中国农业科学院哈尔滨兽医研究所杨勇博：工程化低内毒素细菌仿生囊泡用于增强口服双抗原亚单位疫苗递送

Shen, X., et al. (2025). "Engineered Low-Endotoxin Bacterial Biomimetic Vesicles for Enhanced Oral Dual-Antigen Subunit Vaccine Delivery." 

J Extracell Vesicles 14(12): e70207. IF=14.5

21.武汉大学人民医院李娟娟：乳腺癌分泌的DPP3通过Rap1信号通路重塑肺部血管微环境促进肺转移

Li, X., et al. (2025). "Breast Cancer-Secreted DPP3 Promotes Lung Metastasis by Remodelling the Vascular Niche in Lung via the Rap1 Signalling Pathway."

J Extracell Vesicles 14(12): e70182. IF=14.5

22.南方医科大学南方医院曾庆春：心肌成纤维细胞来源的小细胞外囊泡通过piRNA-62788/PIWIL2介导的SRF沉默减轻纤维化反应

Li, S., et al. (2025). "Cardiac Myofibroblast-Derived Small Extracellular Vesicles Moderate Fibrotic Responses via piRNA-62788/PIWIL2-Mediated SRF Silencing." 

J Extracell Vesicles 14(12): e70204. IF=14.5

23.浙江大学医学院附属第二医院/浙江大学爱丁堡大学联合学院/浙江大学鄂尔多斯鄂托克生物医药联合研究中心周民教授和浙江大学医学院附属第一医院路静合作：普通小球藻细胞外囊泡的鼻脑递送及其抗抑郁作用

Jin, K., et al. (2025). "Nose-to-Brain Delivery of Chlorella vulgaris Extracellular Vesicles for Antidepressant Effects." 

J Extracell Vesicles 14(11): e70198. IF=14.5

24.重庆医科大学蒋立：叶酸修饰的生姜来源类外泌体纳米颗粒共递送舒尼替尼通过抑制PI3K-Akt通路、下调P -糖蛋白和重编程巨噬细胞来抑制肾细胞癌

Xu, H., et al. (2025). "Folic Acid-Modified Ginger-Derived Exosome-Like Nanoparticles Co-Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K-Akt Pathway Inhibition, P-gp Downregulation, and Macrophage Reprogramming." 

Adv Sci (Weinh): e12563. IF=14.1

25.温州医科大学王成贵、王向阳团队：乙酰化通过分子伴侣介导的自噬调节ACSL4降解以缓解椎间盘退变

Wu, Z., et al. (2025). "Acetylation Regulates ACSL4 Degradation Through Chaperone-Mediated Autophagy to Alleviate Intervertebral Disc Degeneration." 

Adv Sci (Weinh): e16015. IF=14.1

26.中山大学孙逸仙纪念医院的宋尔卫院士/黄迪教授团队：肿瘤来源的CDC37抑制树突状细胞中的抗原交叉呈递并损害乳腺癌的抗肿瘤免疫

Wang, R., et al. (2025). "Tumor-Derived CDC37 Inhibits Antigen Cross-Presentation in Dendritic Cells and Impairs Anti-Tumor Immunity in Breast Cancer." 

Adv Sci (Weinh): e06518. IF=14.1

27.江南大学附属医院鲁晓杰团队：鼻黏膜来源的细胞外囊泡作为一种全身性抗衰老干预措施

Shi, W., et al. (2025). "Nasal Mucosa-Derived Extracellular Vesicles as a Systemic Antiaging Intervention." 

Adv Sci (Weinh): e11372.IF=14.1

28.南华大学吴旭、刘文捷、首都医科大学基础医学院张须龙：II型肺泡上皮细胞通过外泌体长链非编码RNA Rmrp释放促进脓毒症诱导的肺泡巨噬细胞免疫抑制

Liu, C., et al. (2025). "Type II Alveolar Epithelial Cells Promote Sepsis-Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release." 

Adv Sci (Weinh): e00376. IF=14.1

29.郑州大学陈真真：原位工程化肿瘤细胞作为自我维持的1型常规树突状细胞（cDC1）编程工厂用于有效的癌症免疫治疗

Jin, S., et al. (2025). "In Situ Engineering of Tumor Cells as Self-Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy." 

Adv Sci (Weinh): e08632. IF=14.1

30.中山大学附属第三医院彭晖教授等：间充质干细胞来源的细胞外囊泡通过代谢和表观遗传调控调节腹膜炎症进程

Huang, Q., et al. (2025). "Mesenchymal Stem Cell-Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation." 

Adv Sci (Weinh): e08645. IF=14.1

31.中山大学附属第一医院的文卫平/雷文斌教授团队：肿瘤来源细胞外囊泡上的PD-L1诱导头颈部鳞状细胞癌中CD8(+) T细胞终末耗竭并介导抗PD-1耐药

Fang, R., et al. (2025). "PD-L1 on Tumor-Derived Extracellular Vesicles Induces CD8(+) T Cell Terminal Exhaustion and Mediates Anti-PD-1 Resistance in Head and Neck Squamous Cell Carcinoma."

Adv Sci (Weinh): e16348.IF=14.1

32.山东大学国家健康医疗大数据研究院侯庆振教授团队：单外泌体多组学数据库SVAltas

Wei, Z., et al. (2025). "SVAtlas: a comprehensive single extracellular vesicle omics resource." 

Nucleic Acids Res. IF=13.1

33.香港中文大学生命科学学院陈斯杰团队：一种用于可视化迁移小体机械时空动态的机械敏感荧光探针

Chen, K., et al. (2025). "A mechanosensitive fluorescent probe for visualizing migrasome mechano-spatiotemporal dynamics." 

Biomaterials 328: 123853. IF=12.9

34.杭州市中医院潘浩/王栋团队：韭菜来源的细胞外囊泡通过AMPK调节线粒体生物发生和自噬并维持肌球蛋白稳态来改善肌肉减少症

Qi, W., et al. (2025). "Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis." 

J Nanobiotechnology 23(1): 721. IF=12.6

35.海军军医大学长海医院消化内科、中国医学科学院基础医学研究所、郑州大学第一附属医院等多机构联合团队：血浆外泌体的综合转录组分析揭示了外分泌和内分泌疾病的分子分层以及慢性胰腺炎中S100A8介导的细胞相互作用

Zhang, D., et al. (2025). "Integrated transcriptome profiling of plasma exosomes reveals molecular stratification of exocrine and endocrine disorders and S100A8-mediated cell interactions in chronic pancreatitis." 

Cell Discov 11(1): 91. IF=12.5

36.复旦大学戚建平：负载微小RNA（miRNA）的仿生纳米颗粒调控肠道微生物以改善炎症性肠病

Liu, W., et al. (2025). "miRNA-loaded biomimetic nanoparticles orchestrate gut microbe to ameliorate inflammatory bowel disease." 

Sci Adv 11(47): eadw5984. IF=12.5

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