由于 Aminex 系列 HPLC 色谱柱在糖类和有机酸检测中的出色应用，因此相关专家随即将其应用扩展到了临床研究领域。
通过对包括唾液、尿液、血液血浆以及其他生物液体中的各种有机酸以及单寡糖的成分检测，可以对诸如代谢缺陷病、糖尿病、肿瘤以及其他类病症、微生物群落情况进行监测和分析，在很多情况下可以作为临床诊断的有效指标之一。
此外，对于血液以及血浆的质量控制，临床试用的药物的制剂包括注射液、口服液等 Aminex 也有着出色的应用。
更多的信息请大家参考下表文献！
以下是 Aminex 色谱柱在临床研究领域的应用文献汇总。
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1. 细菌性阴道病有机酸检测分析 |
Stanek, R., Gain, R. E., Glover, D. D. and Larsen, B., Biomed. Chrom., 6,231-235 (1992).High Performance Ion Exclusion Chromatographic Characterization of the Vaginal Organic Acids in Women with Bacterial Vaginosis. |
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2. 口服液中碳水化合物甜味剂和有机酸的定量 |
Linke, H. A. B. and Moss, S. J., Z. Ernaehrungswiss., 31, 147-154 (1992).Quantitation of Carbohydrate Sweeteners and Organic Acids in Human Oral Fluid Using HPLC Analysis. |
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3. 测定生物体液中的胰岛素 |
Ruo, T. I., Wang, Z., Dordal, M. S. and Atkinson, Jr., A. J., Clinica Chimica Acta, 204, 217-222 (1991). Assay of Insulin in Biological Fluids by HPLC with Pulsed Amperometric Detection. |
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4. 保存的血浆中的抗坏血酸和脱氢抗坏血酸 c 测量 |
Margolis, S. A., Paule, R. C. and Ziegler, R. G., Clin. Chem., 36, 1750-1755 (1990). Ascorbic and Dehydroascorbic Acids Measured in Plasma Preserved with Dithiothreitol or Metaphosphoric Acid. |
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5. 快速分析血浆和尿的有机酸 |
Chong, W. K., Mills, G. A., Weavind, G. P. and Walker, V., J. Chrom., 487,147-153 (1989). HPLC Method for the Rapid Profiling of Plasma and Urinary Organic Acids. |
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6. 测定血液中柠檬酸循环中间体 |
aas, R. H., Breuer, J. and Hammen, M., J. Chrom., 425, 47-57 (1988).HPLC Measurement of Selected Blood Citric Acid Cycle Intermediates. |
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7. 脑乳酸中毒：丙酮酸代谢缺陷导致的脑损伤以及全身酸中毒 |
Brown, G. K., Haan, E. A., Kirby, D. M., Scholem, R. D., Wraith, J. E.,Rogers, J. G. and Danks, D. M., Eur. J. Pediatr., 147, 10-14 (1988).“Cerebral” Lactic Acidosis: Defects in Pyruvate Metabolism with Profound Brain Damage and Minimal Systemic Acidosis. |
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8. 糖尿病患者血浆中的3-羟基-3-甲基戊二酸、己二酸和 2-氧代戊二酸测定 |
Lippe, G., Trevisan, R., Nosadini, R., Fabris, R. and Deana, R., Clin. Biochem.,20, 275-279 (1987).3-Hydroxy-3-Methylglutaric, Adipic, and 2-Oxoglutaric Acids Measured by HPLC in the Plasma from Diabetic Patients. |
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9. 过敏源提取物以及诊断抗原的研究 |
Del Grosso, A. V. and May, J. C., J. Assoc. Off. Anal. Chem., 70, 825-828(1987).Gas Chromatographic, Liquid Chromatographic and Titrimetric Procedures for Determination of Glycerin in Allergenic Extracts and Diagnostic Antigens:Comparative Study. |
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10. 唾液酸的检测 |
Mononen, I., J. Chrom., 381, 219-224 (1986). Detection of Sialuria by Cation-Exchange HPLC. |
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11. 血液中有机酸的检测 |
Halls, H. J. and Teubner, J. K., Clin. Chem., 32, 1979 (1986). Liquid-Chromatographic Determination of Organic Acids in Plasma. |
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12. 生理液中的羧酸：3-羟基-3-甲基戊二酸酸尿症 |
Buchanan, D. N. and Thoene, J. G., Clin. Chem., 32, 169-171 (1986).Photodiode Array Detection for Liquid Chromatographic Profiling of Carboxylic Acids in Physiological Fluids: 3-Hydroxy-3-Methylglutaric Aciduria. |
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12. 生理液中的羧酸：3-羟基-3-甲基戊二酸酸尿症 |
Buchanan, D. N. and Thoene, J. G., Clin. Chem., 32, 169-171 (1986).Photodiode Array Detection for Liquid Chromatographic Profiling of Carboxylic Acids in Physiological Fluids: 3-Hydroxy-3-Methylglutaric Aciduria. |
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12. 生理液中的羧酸：3-羟基-3-甲基戊二酸酸尿症 |
Buchanan, D. N. and Thoene, J. G., Clin. Chem., 32, 169-171 (1986).Photodiode Array Detection for Liquid Chromatographic Profiling of Carboxylic Acids in Physiological Fluids: 3-Hydroxy-3-Methylglutaric Aciduria. |
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13. 新生儿有机酸尿症的检测 |
Allen, K. R., Khan, R. and Watson, D., Clin. Chem., 31, 561-563 (1985).Use of a Diode Array Detector in Investigation of Neonatal Organic Aciduria. |
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14. Milrinone 注射液以及口服液中的乳酸测定 |
Wilson, T.D., J. Liq. Chrom., 8, 1629-1650 (1985). HPLC Determination of Lactic Acid in Milrinone Injection and Oral Solution Using Ion-Exchange Sample Preparation Methods. |
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15. 碳水化合物，有机酸，糖醇的 HPLC 分析 |
Oefner, P., Bonn, G. and Bartsch, G., J. Liq. Chrom., 8, 1009-1023 (1985). Ultrafiltration and HPLC Analysis of Seminal Carbohydrates, Organic Acids and Sugar Alcohols. |
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16. HPLC 快速分析血浆中的有机酸 |
Daish, P. and Leonard, J. V., Clinica Chimica Acta, 146, 87-91 (1985).Rapid Profiling of Plasma Organic Acids by HPLC. |
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17. 有机酸紊乱的筛查 |
Bennett, M. J. and Bradey, C. E., Clin. Chem., 30, 542-546 (1984).Simpler Liquid Chromatographic Screening for Organic Acid Disorders. |
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18. HPLC 检测尿中的寡糖来进行 GM1 神经节苷脂的贮积症诊断 |
Warner, T. G., Robertson, A. D. and O’Brien, J. S., Clin. Chem. Acta, 127, 313-326 (1983).Diagnosis of GM1 Gangliosidosis Based on detection of Urinary Oligosaccharides with HPLC. |
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19. 双柱法进行尿的有机酸分析 |
Buchanan, D. N. and Thoene, J. G., Anal. Biochem., 124, 108-116 (1982).Dual-Column HPLC Urinary Organic Acid Profiling. |
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20. 红细胞的D-葡萄糖测定 |
Wong, S. H., Kalache, G. and Morse, E. E., J. Liq. Chrom., 4, 1831-1845 (1981).HPLC Assay of D-Glucose in Erythrocytes. |
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21. HPLC 法进行尿有机酸分析 |
Buchanan, D. N. and Thoene, J. G., J. Liq. Chrom., 4, 1587-1600 (1981).HPLC Urinary Organic Acid Profiling: Role of the Ultraviolet andAmperometric Detectors. |
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22. a- 酮羧酸的检测 |
Buchanan, D. N. and Thoene, J. G., J. Liq. Chrom., 4, 1219-1224 (1981).Analysis of Alpha-Ketocarboxylic Acids by Ion Exchange HPLC with UV andAmperometric Detection. |
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23. 恶性黑色素瘤和乳腺癌中 N- 乙酰神经氨酸的 HPLC 定量。 |
Silver, H. K. B. and Karim, K. A., J. Chrom., 224, 381-388 (1981).HPLC Quantitation of N-Acetylneuraminic Acid in Malignant Melanoma and Breast Carcinoma. |
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24. HPLC 和光学活测定尿液中的碳水化合物 |
Kuo, J. C. and Yeung, E. S., J. Chrom., 223, 321-329 (1981).Determination of Carbohydrates in Urine by HPLC and Optical Activity Detection. |
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