BMG多功能酶标仪国内用户出版物快报 (2022年5月)

>>>An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

近日四川大学华西医院、香港大学李嘉诚医学院、香港大学深圳医院和海南医科大学关研究团队，联合发表可口服的Mpro抑制剂，用于对抗SARS-CoV-2及其变异体，包括奥密克戎。An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron，研究发现了可口服的对抗SARS-CoV-2的先导化合物，是非常有前景的化合物。研究团队对先导化合物进行了体外和体内药物动力学分析。团队采用德国CLARIOstar多功能读板机来进行酶动力学实验，测试先导化合物的半数有效抑制浓度，抑制常数和失活常数，获取化合物体外动力学数据。BMG的CLARIOstar读板机，配备渐变滤光片荧光光栅，是市面上荧光检测灵敏度最高的光栅型多功能酶标仪，并且具有非常高的灵活性，适用于药物研发过程中各种方法实施。

（原文：https://www.nature.com/articles/s41564-022-01119-7）

>>>RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence

近日，吉林大学基础医学学院和东北师范大学附属中学联合发表了关于骨髓间充质干细胞衰老中的糖代谢特征和动态信号的研究成果-RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence，研究筛选并验证了与葡萄糖代谢相关的 DEG，并研究了糖酵解水平，发现老年大鼠的 MSCs 中的葡萄糖摄取、乳酸分泌、ATP 产生和相对细胞外酸化率 (ECAR) 均减少。研究将揭示代谢对调节干细胞衰老的影响，并为改善与年龄相关的表型提供新的治疗靶点。团队采用德国CLARIOstar来进行ECAR实验，获取细胞外酸化率数据。BMG的CLARIOstar配备专用的ECAR检测模块和检测及分析程序，可以简单快速分析实验结果，帮助用户轻松进行代谢相关检测及分析。

（原文：https://pubmed.ncbi.nlm.nih.gov/35568915/）

Rapid and sensitive noncompetitive immunoassay for detection of aflatoxin B1 based on anti-immune complex peptide

山东农业大学生命科学学院

Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication

香港大学李嘉诚医学院内科血液科

Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo

四川大学华西医院生物治疗与肿瘤中心国家重点实验室

Selective blue-filtering spectacle lens protected primary porcine RPE cells against light emitting diode-induced cell damage

香港理工大学视光学院

MicroRNA214 expression inhibits HCC cell proliferation through PTK2b/Pyk2

三峡大学第一临床医学院

Insulin-like growth factor-1 promotes human uterine leiomyoma cells proliferation via PI3K/AKT/mTOR pathway

华南理工大学医学院附属广州市第一人民医院风湿科

Multi-omics analyses of the transition to the Crabtree effect in S. cerevisiae reveals a key role for the citric acid shuttle

华东理工大学生物反应器工程国家重点实验室

Genome-wide association study of ferulic acid content using 90K and 660K SNP chips in wheat

中国农业科学院国家小麦改良中心作物科学研究所

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

中国科学院大学附属肿瘤医院

Performance characterization of PCR-free whole genome sequencing for clinical diagnosis

安徽医科大学第二附属医院妇产科

Molecular Genetic Screening of Neonatal Intensive Care Units: Hyperbilirubinemia as an Example

常州市妇幼保健院医学遗传学科

RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence

吉林大学基础医学学院病理生物学教育部重点实验室

β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130

香港大学

The flexible N-terminal motif of uL11 unique to eukaryotic ribosomes interacts with P-complex and facilitates protein translation

香港中文大学生命科学学院

Design and Synthesis of Novel Celastrol Derivatives as Potential Anticancer Agents against Gastric Cancer Cells

中国药科大学中药学院

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

国立清华大学分子与细胞生物学研究所生命科学系

A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis

浙江大学医学院附属第一医院肝胆胰外科和浙江省胰腺疾病重点实验室

Pre-miRNA Hsa-Let-7a-2: a Novel Intracellular Partner of Angiotensin II Type 2 Receptor Negatively Regulating its Signals

首都医科大学北京朝阳医院医学研究中心心脏中心心内科

Tubulin-binding peptide RR-171 derived from human umbilical cord serum displays antitumor activity against hepatocellular carcinoma via inducing apoptosis and activating the NF-kappa B pathway

第四军医大学西京医院肝胆外科

HMGCS2 silencing attenuates high glucose-induced in vitro diabetic cardiomyopathy by increasing cell viability, and inhibiting apoptosis, inflammation, and oxidative stress

广西医科大学第一附属医院老年科

New insights into the reverse of chromium-induced reprotoxicity of pregnant mice by melatonin

上海理工大学生态技术与工程学院

The fine mapping of dwarf gene Rht5 in bread wheat and its effects on plant height and main agronomic traits

西北农林科技大学农学院干旱区作物胁迫生物学国家重点实验室

Accumulation of polyethylene microplastics induces oxidative stress, microbiome dysbiosis and immunoregulation in crayfish

河南师范大学生命科学学院

Two types of bacteriophage-modified alginate hydrogels as antibacterial coatings for implants

台北医科大学万方医院内科消化内科

An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

四川大学华西医院生物治疗与肿瘤中心国家重点实验室