BMG多功能酶标仪国内用户出版物快报 (2023年11月)

>>>Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models

瑞典卡罗林斯卡医学院阿尔茨海默病研究中心在专业学术期刊Molecular Psychiatry上发表了题为Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models的文章，吉林大学第一医院耳鼻咽喉头颈外科参与了这项研究工作。科学家在阿尔茨海默动物模型上发现线粒体氧化磷酸化上调，跟氧化损伤和钙超载有关。随着病理发展，线粒体在突触前末梢丰度减少，脑部基础代谢率减退。在AD模型上发现线粒体功能异常出现时间先于细胞自噬损伤和突触混乱。理解病理进程能帮助找寻AD的治疗新方案。

科研工作者借助BMG的CLARIOstar plus多功能酶标仪进行线粒体能量产生，钙保留能力和活性氧产生的的分析。CLARIOstar plus多功能酶标仪高灵敏和高灵活的的荧光以及化学发光分析功能帮助科学家轻松获得相应的数据结果。

（原文：https://www.nature.com/articles/s41380-023-02289-4）

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