BMG多功能酶标仪国内用户出版物快报 (2022年2月)

>>>Ketamine inhibits TNF-α-induced cecal damage by enhancing RIP1 ubiquitination to attenuate lethal SIRS

厦门大学翔安医院、西安交通大学附属第一医院、隆德大学等相关研究团队发表了氯胺酮通过增强 RIP1 泛素化以减弱致死性全身炎症反应综合征来抑制 TNF-α 诱导的盲肠损伤，Ketamine inhibits TNF-α-induced cecal damage by enhancing RIP1 ubiquitination to attenuate lethal SIRS，阐明氯胺酮通过增强 RIP1 泛素化和减少 RIP1-RIP3 和 RIP3-MLKL 相互作用以及坏死体的形成来抑制 TNF-α 诱导的坏死性凋亡，为治疗以 SIRS 相关炎症因子风暴为特征的疾病提供新的理论和实验基础并为氯胺酮的治疗干预和临床应用提供潜在的分子机制和靶点。研究团队采用德国BMG FLUOstar Optima多功能读板机来完成泛素化研究的相关工作。研究团队所用的BMG的POLARstar Omega读板机，使用已经超过10年历史，仪器经久耐用，目前仍然产生高质量数据，为科研工作者日常研究工作提供可靠支持。

（原文：https://www.nature.com/articles/s41420-022-00869-x）

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