BMG多功能酶标仪国内用户出版物快报 (2025年11月)

>>>Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets

华中科技大学同济医学院基础医学院生物化学与分子生物学教研室，重症人畜共患传染病诊疗国家重点实验室，深圳湾实验室，华中科技大学细胞结构研究中心研究团队近日联合在高影响因子专业学术期刊Nature Communications 的论文题为《Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets》，主要揭示了 Sec14L6 作为一种磷酸肌醇转运蛋白，在调节磷酸肌醇稳态和脂滴形成中的关键作用。Sec14L6 是一个关键的磷酸肌醇转运蛋白，通过介导 PI4P 和 PI(4,5)P₂ 在内质网与脂滴之间的转移，调节脂滴的形成和稳态，并在脂肪细胞分化中发挥重要作用。在文章中，CLARIOstar Plus Microplate Reader 用于 体外脂质转移实验中的荧光检测。具体来说：在测定 Sec14L6 对 PI4P 和 PI(4,5)P₂ 的转运活性时，使用 NBD 标记的脂质探针；CLARIOstar 用于监测 NBD 荧光强度的变化，从而量化脂质从供体脂质体向受体脂质体的转移效率；该仪器还在 FRET 实验 中用于检测 Sec14L6 构象变化，以及在其他脂质转移活性测试中提供高灵敏度的荧光读数。                                            

BMG的CLARIOstar 酶标仪具有高灵敏的可媲美滤光片的荧光光栅系统，针对荧光信号变化，CLARIOstar 酶标仪动态范围扩展技术可免去实验条件的优化步骤，动态范围单次检测可达8个数量级，不用担心信号增加后的溢出风险，为实验室平台和广大科研人员提供最佳的检测数据。

（原文：https://www.nature.com/articles/s41467-025-65540-2）

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