BMG多功能酶标仪国内用户出版物快报 (2022年4月)

>>>Targeting papain-like protease for broad-spectrum coronavirus inhibition

近日来自香港大学李嘉诚医学院和中国医学科学院北京协和医学院的关研究团队，发表广谱的抗冠状病毒药剂的作用靶点的研究进展成果-Targeting papain-like protease for broad-spectrum coronavirus inhibition，研究发现Plpro是开发广谱的抗冠状病毒药剂的有效的作用靶点。F0213可能是对抗COVID-19的大规模流行和未来冠状病毒有希望的候选化合物。其中，研究团队采用德国BMG PHERAstar FSX多功能读板机来完成蛋白酶切割分析。BMG的PHERAstar FSX读板机，配备荧光检测的优化光学模块，是市面上荧光检测灵敏度最高的多功能酶标仪，适用于384板或者更高通量的药物筛选。

（原文：https://link.springer.com/article/10.1007/s13238-022-00909-3）

Populations of Puccinia striiformis f. sp. tritici in Winter Spore Production Regions Were Spread from Southwestern Oversummering Areas in China

西北农林科技大学植物保护学院

Piezodeposition of Metal Cocatalysts for Promoted Piezocatalytic Generation of Reactive Oxygen Species and Hydrogen in Water

山东大学口腔医学院

A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway

中山大学药学院

A bio-responsive, cargo-catchable gel for postsurgical tumor treatment via ICD-based immunotherapy

中国药科大学药学院药学系天然药物国家重点实验室

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

中山大学药学院

Histone demethylase KDM5A regulates the functions of human periodontal ligament stem cells during periodontitis via the miR-495-3p/HOXC8 axis

郑州大学第一附属医院口腔种植与修复科

Engineering and Structural Insights of a Novel BBI-like Protease Inhibitor Livisin from the Frog Skin Secretion

温州医科大学药学院化学生物学研究中心

A Sub-6 nm MnFe2O4-dichloroacetic acid nanocomposite modulates tumor metabolism and catabolism for reversing tumor immunosuppressive microenvironment and boosting immunotherapy

南京大学化学化工学院高分子科学与工程系

GRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer Patients

南开大学医学院细胞生物学系

miR-203, fine-tunning neuroinflammation by juggling different components of NF-κB signaling

暨南大学广州市病毒学重点实验室

Dietary Choline Alleviates High-Fat Diet-Induced Hepatic Lipid Dysregulation via UPRmt Modulated by SIRT3-Mediated mtHSP70 Deacetylation

华中农业大学水产学院

Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors

浙江大学化学与生物工程学院杭州创新中心

Upregulated YAP promotes oncogenic CTNNB1 expression contributing to molecular pathology of hepatoblastoma

郑州大学第三附属医院小儿外科

Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway

河北医科大学药理学系

Bromodomain containing 4 transcriptionally activated Deltex E3 ubiquitin ligase 2 contributes to glioma progression and predicts an unfavorable prognosis

福建省立医院南院神经外科

Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity

北京中医药大学中药学院

A noncoding regulatory RNA Gm31932 induces cell cycle arrest and differentiation in melanoma via the miR-344d-3-5p/Prc1 (and Nuf2) axis

滨州医科大学中西医结合学院

Design, synthesis and biological evaluation of novel nitric oxide donors with antioxidative activity

第四军医大学药学院化学系

Targeting papain-like protease for broad-spectrum coronavirus inhibition

香港大学李嘉诚医学院新发传染病国家重点实验室

Protein disulfide isomerase modulation of TRPV1 controls heat hyperalgesia in chronic pain

河北医科大学神经与血管生物学教育部重点实验室

Niacin promotes the efflux of lysosomal cholesterol from macrophages via the CD38/NAADP signaling pathway

桂林医科大学附属医院心内科

DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo

贵州医科大学药用植物功能与应用国家重点实验室

Two Main Routes of Spore Migration Contributing to the Occurrence of Wheat Stripe Rust in the Jiangsu and Zhejiang Costal Sporadic Epidemiological Region in 2019 Based on Phenotyping and Genotyping Analyses

西北农林科技大学

Effects of Abelmoschus manihot Flower Extract on Enhancing Sexual Arousal and Reproductive Performance in Zebrafish

义守大学医学院留学生医学院

Fragment-Based Discovery of AF9 YEATS Domain Inhibitors

中国科学技术大学生命科学

Influence of modification methods on physicochemical and structural properties of soluble dietary fiber from corn bran

吉林农业大学食品科学与工程学院