BMG多功能酶标仪国内用户出版物快报 (2024年7月)

>>>Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway

河北省中西医结合研究院，罗冰理论创新与转化国家重点实验室，石家庄亿灵药业有限公司新药评价中心联合在专业学术期刊British Journal of Pharmacology发表了题为Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway的文章，破译甘草次酸 （GA） 的潜在抗 SARS-CoV-2 机制。GA 的抗 SARS-CoV-2 作用在体外和体内均得到了验证。采用均相时间分辨荧光测定、生物膜干涉测量技术和分子对接来检查 GA 与干扰素基因人类刺激物 （hSTING） 的相互作用。免疫荧光染色、western blot 和 RT-qPCR 检测干扰素调节因子 3 （IRF3） 的核转位和 STING 靶基因水平。

科研工作者借助使用 BMG的PHERAstar FSX 多功能微孔板检测系统采用时间分辨 （TR） -荧光共振能量转移 （FRET） 测定来评估 ACE2-Spike 结合抑制活性。采用 FRET 测定法评估对 3CL 蛋白酶 （3CLpro） 的抑制活性。采用 CLARIOstar Plus 多功能微孔板检测系统评估荧光值。高通量高灵敏度BMG的PHERAstar FSX 多功能微孔板检测系统和高灵敏高度灵活的CLARIOstar Plus 多功能微孔板检测系统是用于药物筛选和药物研发的有力工具。

（原文：https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16473）

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Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway

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