AT LISA tri 839MP作为多焦点人工晶状体的标杆之一，自上市以来，已经积累了丰富的临床研究证据，证明其优质的屈光性能，可预测性和术后视觉质量。
自2012年以来，已有超过80篇同行评审的研究性论文，超过4500名患者（9000眼）植入AT LISA tri 839MP的术后结果。AT LISA tri 839MP为眼科医生提供了一种术后视觉质量和患者满意度方面都具有优越表现的人工晶状体。
高满意度✦
AT LISA tri 839MP已发表文献，有23篇明确调查了患者术后满意度。其中8篇研究证实患者的术后满意度达到了100% 3, 12, 19, 22, 28, 35, 45, 47，另外9篇研究显示患者满意度高于90%2, 4, 6, 18, 24, 29, 30, 34, 36。例如，Kretz等人19的一项前瞻性研究发现，几乎所有患者(100%)都对手术结果表示满意。具体来说，“所有患者都对他们的阅读视力、中视力、远视力、所有距离的视觉质量感到满意，且日常活动及使用电脑时可以脱镜”。 Florian Kretz表示：“临床上，患者不仅获得了良好的视觉质量和屈光效果，还拥有较高的脱镜率，较低的视觉干扰，这些都使我们的患者满意度很高。”
优异的全程视力 —— 远视力
通过对这些研究的 meta 分析证实，AT LISA tri 839MP提供了优异的远、中、近全程视力。所有评估双眼未矫正远视力(UDVA)的研究均证实，AT LISA tri 839MP植入术后患者双眼UDVA 均优于0.1 logMAR1-8, 10-23, 25-29, 31-35, 37-39, 41-47。
点击放大查看
优异的全程视力 —— 中视力
关于三焦点人工晶状体，一个经常被讨论的关键问题是中视力，因为中视力用于满足数字化时代的阅读需求。大量的研究结果显示，AT LISA tri 839MP术后患者双眼平均UIVA为0.1 logMAR或更好14, 16-19, 22, 28, 34, 39。中距离的视力对于满足人们购物、使用电脑和智能手机以及读取汽车仪表盘上的数字等日常活动至关重要。
Kretz17研究发现，AT LISA tri 839MP术后患者的中视力结果非常好，79%术眼UIVA达到0.1 logMAR甚至更好，94%达到0.2 logMAR甚至更好，所有术眼均达到0.3 logMAR或更好。
点击放大查看
优异的全程视力 —— 近视力
老视矫正型人工晶状体的主要目标之一是能够拥有良好的近视力并摆脱对眼镜的依赖。AT LISA tri 839MP在近视力方面同样表现不凡2-4, 6, 7, 9, 25, 27, 29, 31, 35, 37, 39, 47。
其中21篇研究结果，患者双眼UNVA均优于0.2 logMAR。
Abdulmohsen K. Almulhim教授表示 “中视力的重要性再怎么强调也不为过。AT LISA tri 839MP三焦点人工晶状体不仅提供了优秀的中视力，同时还保证了远视力和近视力不受影响。”
点击放大查看
稳定的屈光结果
大量研究证实，AT LISA tri 839MP提供可预测且稳定的屈光结果。Kretz2等人报道，术后3个月植入839MP的100眼中，90%等效球镜度（SE）为± 0.50D。Mendicute1研究表明，在术后1个月和3个月SE在±0.50 D范围内的比例分别为177例(85.9%)和171例(83.0%)。在术后1个月和3个月时，196眼(95.1%)和201眼(97.6%)的预期屈光度在±1.00 D内。
在一项前瞻性研究中，Ganesh8等发现839MP术后的屈光结果具有良好的长期稳定性，并且在术后1个月、6个月和12个月的SE差异无统计学意义。
Yang Yang教授表示：“总体而言，植入AT LISA tri 839MP后，无论是在明亮或者昏暗的条件下都改善了患者的视觉功能且保持稳定。”
高脱镜率
如今，患者希望实现所有距离脱镜而不仅仅是近距离脱镜。其中12项有评价患者术后脱镜率的研究发现，AT LISA tri 839MP在所有距离上均有较高的脱镜率4, 6, 7, 10, 12, 17, 18, 20, 23, 25, 27, 29, 30, 36, 45, 47。
在一项多中心前瞻性研究中，Mendicute等人28报道，植入839MP的患者3个月后在所有距离上的脱镜率均高于90%，远中近距离分别为99%，95.1%，89.2%。
Javier Mendicute总结到：“在我们植入839MP的患者中，患者满意度高(超过90%)主要得益于839MP给他们带来了优质的远、中及近视力，高脱镜率(超过90%)以及极低的光干扰现象。”
点击放大查看
总结
自AT LISA tri 839MP上市以来，大量临床研究证实，AT LISA tri 839MP三焦点人工晶状体提供出色的远、中、近全程视力，患者术后屈光状态稳定，脱镜率高，满意度高。
参考文献：
向上滑动阅览
1 Alfonso JF, Fernández-Vega Cueto L, Belda-Salmerón L,et al. Visual function after implantation of a diffractive aspheric trifocal intraocular lens. Eur J Ophthalmol 2016;26(5):405–11.
2 Alió JL, Kaymak H, Breyer D, et al. Quality of life related variables measured for three multifocal diffractive intraocular lenses: A prospective randomised clinical trial.Clinical & Experimental Ophthalmology 2017.
3 Al-Khateeb G, Shajari M, Kohnen T. Intraindividual comparative analysis of the visual performance after cataract surgery with implantation of a trifocal and a bifocal intraocular lens. J Cataract Refract Surg 2017;43(5):695–98.
4 Almulhim AK, Alarfaj KM, Altaisan AA, Alromaih AZ, Aldawod RA. Visual outcomes and patient satisfaction after bilateral implantation of a new trifocal diffractive intraocular lens. Saudi J Ophthalmol.2018 Oct–Dec;32(4):310–317.
5 Ang RE. Comparison of tolerance to induced astigmatism in pseudophakic eyes implanted with small aperture, trifocal, or monofocal intraocular lenses. Clin Ophthalmol.2019 May 30;13:905-911. doi: 10.2147/OPTH.S208651.eCollection 2019.
6 Bilbao-Calabuig R, Llovet-Rausell A, Ortega-Usobiaga J,et al. Visual Outcomes Following Bilateral lmplantation of Two Diffractive Trifocal IOLs in 10 084 eyes.American Journal of Ophthalmology 2017.
7 Böhm M, Hemkeppler E, Herzog M, Schönbrunn S, de’Lorenzo N, Petermann K, Kohnen T. Comparison of a panfocal and trifocal diffractive intraocular lens after femtosecond laser-assisted lens surgery. J Cataract Refract Surg. 2018 Dec;44(12):1454-1462.
8 Brito P, Salgado-Borges J, Neves H, et al. Light-distortion analysis as a possible indicator of visual quality after refractive lens exchange with diffractive multifocal intraocular lenses. J Cataract Refract Surg 2015;41(3): 613–22.
9 Chen S-Y, Xie C, Wang Y, et al. Full-vision maintenance in extrahigh myopia from implantable collamer lens totrifocal intraocular lens implantation. Int J Ophthalmol 2018;11(7):1239–42.
10 Chow SSW, Chan TCY, Ng ALK, Kwok AKH. Outcomes of presbyopia-correcting intraocular lenses after laser in situ keratomileusis. Int Ophthalmol.2019 May;39(5): 1199-1204.
11 Farideh D, Azad S, Feizollah N, et al. Clinical outcomes of new toric trifocal diffractive intraocular lens in patients with cataract and stable keratoconus: Six months followup. Medicine (Baltimore) 2017;96(12):e6340.
12 Ganesh S, Brar S, Pawar A. Long-term visual outcomes and patient satisfaction following bilateral implantation of trifocal intraocular lenses. Clin Ophthalmol 2017;11: 1453–59. 28860693.
13 Gerl M, Breyer DRH, Hagen P, et al. Klinischer Vergleich einer trifokalen und einer trifokaltorischen Intraokularlinse auf gleicher diffraktiver Plattform: Clinical Comparison of a Trifocal and a Trifocal-Toric Intraocular Lens Based on the Same Diffractive Platform. Klin Monbl Augenheilkd 2017.
14 Höhn F, Tandogan T, Breyer DRH, et al. Funktionelle Ergebnisse 1 Jahr nach Implantation einer bitorischen, trifokalen Intraokularlinse. Klin Monbl Augenheilkd.2015;232(8):957–61.
15 Kim BH, Hyon JY, Kim MK. Effects of Bifocal versus Trifocal Diffractive Intraocular Lens Implantation on Visual Quality after Cataract Surgery. Korean J Ophthalmol.2019 Aug;33(4):333-342.
16 Kim M, Kim JH, Lim TH, et al. Comparison of Reading Speed after Bilateral Bifocal and Trifocal Intraocular Lens Implantation. Korean J Ophthalmol 2018;32(2):77–82.
17 Kohnen T, Titke C, Böhm M. Trifocal Intraocular Lens Implantation to Treat Visual Demands in Various Distances Following Lens Removal. American Journal of Ophthalmology 2016;161:71-7.e1 (accessed 19 Apr 2016).
18 Kretz FTA, Choi CY, Müller M, et al. Visual Outcomes, Patient Satisfaction and Spectacle Independence with a Trifocal Diffractive Intraocular Lens. Korean J Ophthalmol 2016;30(3):180–91.
19 Kretz, Florian T A, Breyer D, Diakonis VF, et al. Clinical Outcomes after Binocular Implantation of a New Trifocal Diffractive Intraocular Lens. Journal of Ophthalmology 2015; 2015:962891.
20 Kretz, Florian T A, Breyer D, Klabe K, et al. Clinical Outcomes After Implantation of a Trifocal Toric Intraocular Lens. J Refract Surg 2015;31(8):504–10.
21 Kretz, Florian T A, Müller M, Gerl M, et al. Binocular function to increase visual outcome in patients implanted with a diffractive trifocal intraocular lens. BMC Ophthalmol 2015;15:110.
22 Law EM, Aggarwal RK, Kasaby H. Clinical outcomes with a new trifocal intraocular lens. Eur J Ophthalmol
2014;24(4):501–08.
23 Lenton L. Visual performance in a flight simulator: multifocal intraocular lenses in pilots. BMJ Open Ophthalmol 2018;3(1):e000139.
24 Liu X, Xie L, Huang Y. Comparison of the Visual Performance After Implantation of Bifocal and Trifocal
Intraocular Lenses Having an Identical Platform. J Refract Surg 2018;34(4):273–80.
25 Marques EF, Ferreira TB. Comparison of visual outcomes of 2 diffractive trifocal intraocular lenses. J Cataract Refract Surg 2015;41(2):354–63. 25661129.
26 Martínez de Carneros-Llorente A, Martínez de Carneros A, Martínez de Carneros-Llorente P, Jiménez-Alfaro I.Comparison of visual quality and subjective outcomes among 3 trifocal intraocular lenses and 1 bifocal intraocular lens. J Cataract Refract Surg. 2019 May;45(5):587-594.
27 Martinez-de-la-Casa JM, Carballo-Alvarez J, Garcia-Bella J, et al. Photopic and mesopic performance of 2 different trifocal diffractive intraocular lenses. Eur J Ophthalmol 2016:0.
28 Mencucci R, Favuzza E, Caporossi O, et al. Comparative analysis of visual outcomes, reading skills, contrast sensitivity, and patient satisfaction with two models of trifocal diffractive intraocular lenses and an extended range of vision intraocular lens. Graefes Arch Clin Exp Ophthalmol 2018.
29 Mencucci R, Favuzza E, Caporossi O, et al. Visual performance, reading ability and patient satisfaction after implantation of a diffractive trifocal intraocular lens. Clin Ophthalmol 2017;11:1987–93.
30 Mendicute J, Kapp A, Levy P, et al. Evaluation of visual outcomes and patient satisfaction after implantation of a diffractive trifocal intraocular lens. J Cataract Refract Surg 2016;42(2):203–10.
31 Mojzis P, Kukuckova L, Majerova K, et al. (2017). Postoperative visual performance with a bifocal and trifocal diffractive intraocular lens during a 1-year follow-up. Int J Ophthalmol, 17 October 2017:1528–33.
32 Mojzis P, Kukuckova L, Majerova K, et al. Comparative analysis of the visual performance after cataract surgery with implantation of a bifocal or trifocal diffractive IOL. J Refract Surg 2014;30(10):666–72.
33 Mojzis P, Majerova K, Hrckova L, et al. Implantation of a diffractive trifocal intraocular lens: one-year follow-up. J Cataract Refract Surg 2015;41(8):1623–30.
34 Mojzis P, Majerova K, Plaza-Puche AB, et al. Visual outcomes of a new toric trifocal diffractive intraocular lens. J Cataract Refract Surg 2015;41(12):2695–706.
35 Mojzis P, Peña-García P, Liehneova I, et al. Outcomes of a new diffractive trifocal intraocular lens. J Cataract
Refract Surg 2014;40(1):60–69.
36 Piovella M, Colonval S, Kapp A, et al. Patient outcomes following implantation with a trifocal toric IOL: twelvemonth prospective multicentre study. Eye (Lond).
37 Plaza-Puche AB, Alio JL, Sala E, et al. Impact of low mesopic contrast sensitivity outcomes in different types of modern multifocal intraocular lenses. Eur J Ophthalmol 2016:0.
38 Plaza-Puche AB, Alio JL. Analysis of defocus curves of different modern multifocal intraocular lenses. Eur J Ophthalmol 2016:0.
39 Postolache C, Postolache O. Comparation of refractive results with bifocal implants AT LISA 809 and trifocal AT LISA tri 839. Rom J Ophthalmol 2015;59(2):100–02.
40 Qi Y, Lin J, Leng L, et al. Role of angle κ in visual quality in patients with a trifocal diffractive intraocular lens. J Cataract Refract Surg 2018;44(8):949–54.
41 Sezgin Asena B. Visual and refractive outcomes, spectacle independence, and visual disturbances after cataract or refractive lens exchange surgery: Comparison of 2 trifocal intraocular lenses. J Cataract Refract Surg. 2019 Nov;45(11):1539-1546.
42 Steinwender G, Schwarz L, Böhm M, et al. Visual results after implantation of a trifocal intraocular lens in high myopes. J Cataract Refract Surg 2018;44(6):680–85.
43 Tarib I, Diakonis VF, Breyer D, Höhn F, Hahn U, Kretz FTA. Outcomes of combining a trifocal and a lowaddition bifocal intraocular lens in patients seeking spectacle independence at all distances. J Cataract Refract Surg. 2019 May;45(5):620-629.
44 Velasco-Barona C, Corredor-Ortega C, Mendez-Leon A, Casillas-Chavarın N L.,Valdepeña-Lopez Velarde D, Cervantes-Coste G, Malacara-Hernandez D and Gonzalez-Salinas R. Influence of angle κ and higher-order
aberrations on visual quality employing two diffractive trifocal IOLs: (AT LISA tri 839MP vs Acrysof IQ PanOptix). Journal of Ophthalmology 2019, Article ID 7018937.
45 Wang W, Ni S, Li X, et al. Femtosecond laser-assisted cataract surgery with implantation of a diffractive trifocal intraocular lens after laser in situ keratomileusis: a case report. BMC Ophthalmol 2018;18(1):160.
46 Xue S, Zhao G, Yin X, et al. Effect of incision on visual outcomes after implantation of a trifocal diffractive IOL. BMC Ophthalmol 2018;18(1):171.
47 Yang Y, Lv H, Wang Y, et al. Clinical outcomes following trifocal diffractive intraocular lens implantation for age-related cataract in China. Clin Ophthalmol 2018; 12:1317–24.