RNA甲基化
2025发文速览
宾夕法尼亚大学宋洪军、明国莉团队
Shen Y, Wong SZH, Ma T, et al. m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice. Cell Stem Cell. Published online March 12, 2025. doi:10.1016/j.stem.2025.02.011
上海市眼窝疾病与眼部肿瘤重点实验室
Gu, Xiang et al. “Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A.” Nucleic acids research vol. 52,5 (2024): 2273-2289. doi:10.1093/nar/gkad1193
郑大一附院&中国科学院
Li, Ouwen et al. “Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma.” Clinical and translational medicine vol. 15,3 (2025): e70270. doi:10.1002/ctm2.70270
重庆大学附属肿瘤医院
Liu, Yi et al. “The 7-Methylguanosine (m7G) methylation METTL1 acts as a potential biomarker of clear cell renal cell carcinoma progression.” Translational oncology vol. 51 (2025): 102202. doi:10.1016/j.tranon.2024.102202
扩展阅读
专题集锦 | 信号通路、蛋白翻译后修饰（PTMs）、肿瘤癌症、肺癌、胃癌、肝癌、胰腺癌、乳腺癌、甲状腺癌、鼻咽癌、结直肠癌、巨噬细胞、自噬、泛素、凋亡、焦亡、铁死亡、免疫、炎症、脓毒症、衰老、阿尔茨海默病、肥胖、糖尿病、肾病、血管生成、心脑血管、肝病、呼吸、结核病、皮肤、眼科、妇科、干细胞、外泌体、类器官、组织工程、骨科、新药研发、中医药、多糖、神奇动物、病毒、麻醉……
▼ RayBio®抗体芯片近期部分学术引用
| Year | Journal | 2023 IF | Article Title |
| 2017 | Nature Communications | 16.6 | Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis |
| 2017 | Nature Immunology | 30.5 | Direct control of regulatory T cells by keratinocytes |
| 2017 | Nature | 64.8 | Cytoplasmic chromatin triggers inflammation in senescence and cancer |
| 2017 | Nature Medicines | 82.9 | Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms |
| 2018 | Acta Biomaterialia | 9.7 | Manipulation of the response of human endothelial colony-forming cells by focal adhesion assembly using gradient nanopattern plates |
| 2018 | Journal for Immuno Therapy of Cancer | 10.9 | Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma 5-year follow up and additional analyses |
| 2018 | Arthritis & Rheumatology | 13.3 | Myogenic Progenitor Cells Exhibit Type I Interferon–Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis |
| 2018 | Hepatology | 13.5 | Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type-A Receptor 5 Kinases in Hepatocellular Carcinoma |
| 2018 | Hepatology | 13.5 | Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2 |
| 2018 | Cell Host & Microbe | 30.3 | Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation |
| 2018 | Cell | 64.5 | CD10+ GPR77+ cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness |
| 2019 | Theranostics | 12.4 | Monoclonal Antibody againstCXCL1 (HL2401) as a Novel Agent in Suppressing IL6 Expression and Tumoral Growth |
| 2019 | Neurology | 9.9 | Changes in cerebralautoregulation and blood biomarkers after remote ischemic preconditioning |
| 2019 | Nature Communications | 16.6 | Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children |
| 2019 | Nature Communications | 16.6 | Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling |
| 2019 | Nature Cell Biology | 21.3 | NAD+ metabolism governs the proinflammatory senescence-associated secretome |
| 2019 | Nature Medicine | 82.9 | Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity |
| 2019 | Cell Research | 44.1 | Sodium oligomannate therapeutically remodels gutmicrobiota and suppresses gut bacterial amino acids-shaped neuroinflammation toinhibit Alzheimer’s disease progression |
| 2019 | Cell | 64.5 | Regional activation of myosin II in cancer cells drives tumor progression via a secretory cross-talk with the immune microenvironment |
| 2020 | Theranostics | 12.4 | Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells |
| 2020 | Theranostics | 12.4 | Plasma protein-based signature predicts distant metastasis and inductionchemotherapy benefit in Nasopharyngeal Carcinoma |
| 2020 | Molecular Therapy | 12.4 | HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis |
| 2020 | Acta Pharmaceutica Sinica B | 14.5 | Chrysin serves as a novel inhibitor of DGKa/FAK interaction to suppress the malignancy of esophageal squamous cellcarcinoma (ESCC) |
| 2020 | Journal of Extracellular Vesicles | 16 | Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innatelymphoid cell-dominant allergic airway inflammation through delivery ofmiR-146a-5p |
| 2020 | Nature Communications | 16.6 | Distinct effects of generalanesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models |
| 2020 | Molecular Cell | 16.6 | Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment |
| 2020 | Immunity | 32.4 | Excessive polyamine generation in keratinocytes promotes self-RNA sensing by dendritic cells in psoriasis |
| 2021 | Pharmacological Research | 9.3 | Affiliated Hospital of Integrated Traditional Chinese and WesternMedicine, Nanjing University of Chinese Medicine |
| 2021 | Theranostics | 12.4 | Intravenous transplantationof olfactory ensheathing cells reduces neuroinflammation after spinal cordinjury via interleukin-1 receptor antagonist |
| 2021 | Theranostics | 12.4 | Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer |
| 2021 | Hepatology | 13.5 | Group-2 Innate LymphoidCells Promote Hepatocellular Carcinoma Progression via CXCL2-Neutrophil Induced Immunosuppression |
| 2021 | Nature Cell Biology | 21.3 | m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype |
| 2021 | Signal Transduction and Targeted Therapy | 39.3 | Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer |
| 2021 | Cancer Cell | 50.3 | Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms |
| 2022 | Journal for ImmunoTherapy of Cancer | 10.9 | Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade |
| 2022 | PNAS | 11.1 | Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients |
| 2022 | Advanced Science | 15.1 | Mouse Modeling Dissecting Macrophage–BreastCancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis |
| 2022 | Nature Microbiology | 28.3 | Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions |
| 2023 | Nature Metabolism | 20.8 | TREM2hiresident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis |
| 2023 | Journal of Hematology & Oncology | 28.5 | LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia |
| 2023 | Cancer Cell | 50.3 | Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling |
▼ RayBio®ELISA近期部分学术引用
| Year | Journal | 2023 IF | Article Title |
| 2017 | Science Translational Medicine | 17.1 | Detection of early pancreatic ductal adenocarcinoma using thrombospondin-2 and CA19-9 blood markers |
| 2017 | JAMA Internal Medicine | 39.0 | Association of Ozone Exposure With Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults |
| 2017 | Journal of Clinical Investigation | 15.9 | Thrombin promotes diet-induced obesity through fibrin-driven inflammation |
| 2017 | Nature Medicine | 82.9 | Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates |
| 2017 | Nature Communications | 16.6 | Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis |
| 2018 | Nature | 64.8 | Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome |
| 2018 | Autophagy | 13.3 | HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer |
| 2020 | Annals of Surgery | 9.0 | Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma |
| 2020 | Nature Communications | 16.6 | Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans |
| 2020 | Nature Communications | 16.6 | Chemotaxis-driven delivery ofnano-pathogenoids for co mplete eradication oftumorspost-phototherapy |
| 2020 | Nature Communications | 16.6 | Receptor-targetedengineered probiotics mitigatele thal Listeria infection |
| 2020 | Brain Behavior and Immunity | 15.1 | Increased vulnerability to impulsive behavior after streptococcal antigen exposure and antibiotic treatment in rats |
| 2020 | Cell Metabolism | 29.0 | Defined p16High Senescent Cell Types Are Indispensablefor Mouse Healthspan |
| 2020 | Immunity | 32.4 | Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis |
| 2020 | Cell | 64.5 | Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures |
| 2021 | Journal of Clinical Investigation | 15.9 | Mutant SF3B1 promotes AKT-and NF-KB-driven mammary tumorigenesis |
| 2022 | Biomaterials | 14.0 | Dual-functionalhydrogel systemfor spinal cordr egeneration with sustained releaseofarylsulfataseBalleviatesfibrotic mi croenvironment and promotes axonalregeneration |
