抗体芯片免疫研究文献集锦
1、肿瘤免疫应答与精神疾病交叉研究
杂志名称：Nature medicine
影响因子：2023 IF 82.9
文章题目：Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity
第一作者：Heng Yang
作者单位：中国医学科学院和北京协和医科大学
本实验所用产品：AAM-BLG-1
芯片名称：Mouse L308 Array, Glass Slide
检测指标：308个
芯片类型：标记法玻璃芯片，半定量
详情链接：https://www.raybiotech.com/mouse-l308-array-glass-slide-aam-blg-1
实验样品类型：小鼠血浆
该研究证明精神压力等应激反应能够诱导糖皮质激素的迅速上升和Tsc22d3上调，抗体芯片检测结果显示所有重要免疫指标均被抑制，这会削弱抗癌疗法诱导的免疫监视作用，诱导免疫抑制降低化疗，免疫治疗等疗法的效率。此外在多种癌症包括消化道癌症、肺癌及黑色素瘤患者中也发现血浆皮质醇水平及TSC22D3在循环白细胞中的高表达，这与患者的消极情绪密切相关，并且预示较差的预后及生存率。因此糖皮质激素及其下游效应分子Tsc22d3可能作为“免疫检查点”，中和或阻断其作用可能有效地提高抗癌治疗的疗效。另一方面也提示人们需要多关注患者的精神障碍及调节、谨慎使用糖皮质激素类药物，为提高疗效提供了新的战略思路。
抗体芯片免疫研究文献集锦
2、免疫病治疗策略研究
杂志名称：Immunity
影响因子：2023 IF 32.4
文章题目：Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis
第一作者：Fangzhou Lou
作者单位：上海交通大学医学院，上海免疫研究所，上海总医院转化医学中心，上海细胞分化与凋亡教育部重点实验室
本实验所用产品：GSM-CAA-4000
芯片名称：Mouse Cytokine Array GS4000
检测指标：200个
芯片类型：夹心法玻璃芯片，半定量
详情链接：https://www.raybiotech.com/mouse-cytokine-array-gs4000-gsm-caa-4000
实验样品类型：细胞组织
该研究首次揭示，组织特异性细胞的代谢重编程所引起的代谢物异常累积是银屑病等慢性炎症性疾病发生发展的重要“帮凶”，GSM-CAA-4000芯片结果表明表皮细胞的“多胺+自身核酸+短肽”复合物是激活皮肤免疫反应的“自身抗原”，并影响IL17相关细胞因子表达变化，促进病情发展。而靶向调节表皮细胞精氨酸代谢通路的异常有望成为治疗银屑病的全新策略。
抗体芯片免疫研究文献集锦
3、肿瘤治疗机制研究
杂志名称：Nature Communications
影响因子：2023 IF 16.6
文章题目：The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells
第一作者：Xue Chen
作者单位：上海交通大学生命科学学院；上海交通大学医学院生物化学与分子细胞生物学教研室，细胞分化与凋亡教育部重点实验室；
本实验所用产品：AAM-CUST-8
芯片名称：Mouse Cytokine Antibody Array
芯片类型：定制款，膜芯片，半定量
实验样品类型：血小板上清液
研究团队发现血小板特异性Pten缺陷小鼠能够发生与年龄相关的淋巴细胞增生和自身免疫性疾病，通过使用小鼠细胞因子抗体芯片(AAM-CUST-8)比较了野生型及Pten缺陷型血小板上清中细胞因子的表达水平，发现PTEN缺陷能够过量产生Tfh相关的细胞因子。随后通过一系列实验证明Pten缺陷型血小板能够增强其与CD4+T细胞的相互作用，促进Tfh细胞分化，并能够浸润到淋巴组织并形成聚集体。
其他免疫学相关研究使用产品文献推荐
▼ RayBio®抗体芯片近期部分学术引用
| Year | Journal | 2023 IF | Article Title |
| 2017 | Nature Communications | 16.6 | Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis |
| 2017 | Nature Immunology | 30.5 | Direct control of regulatory T cells by keratinocytes |
| 2017 | Nature | 64.8 | Cytoplasmic chromatin triggers inflammation in senescence and cancer |
| 2017 | Nature Medicines | 82.9 | Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms |
| 2018 | Acta Biomaterialia | 9.7 | Manipulation of the response of human endothelial colony-forming cells by focal adhesion assembly using gradient nanopattern plates |
| 2018 | Journal for Immuno Therapy of Cancer | 10.9 | Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma 5-year follow up and additional analyses |
| 2018 | Arthritis & Rheumatology | 13.3 | Myogenic Progenitor Cells Exhibit Type I Interferon–Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis |
| 2018 | Hepatology | 13.5 | Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type-A Receptor 5 Kinases in Hepatocellular Carcinoma |
| 2018 | Hepatology | 13.5 | Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2 |
| 2018 | Cell Host & Microbe | 30.3 | Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation |
| 2018 | Cell | 64.5 | CD10+ GPR77+ cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness |
| 2019 | Theranostics | 12.4 | Monoclonal Antibody againstCXCL1 (HL2401) as a Novel Agent in Suppressing IL6 Expression and Tumoral Growth |
| 2019 | Neurology | 9.9 | Changes in cerebralautoregulation and blood biomarkers after remote ischemic preconditioning |
| 2019 | Nature Communications | 16.6 | Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children |
| 2019 | Nature Communications | 16.6 | Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling |
| 2019 | Nature Cell Biology | 21.3 | NAD+ metabolism governs the proinflammatory senescence-associated secretome |
| 2019 | Nature Medicine | 82.9 | Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity |
| 2019 | Cell Research | 44.1 | Sodium oligomannate therapeutically remodels gutmicrobiota and suppresses gut bacterial amino acids-shaped neuroinflammation toinhibit Alzheimer’s disease progression |
| 2019 | Cell | 64.5 | Regional activation of myosin II in cancer cells drives tumor progression via a secretory cross-talk with the immune microenvironment |
| 2020 | Theranostics | 12.4 | Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells |
| 2020 | Theranostics | 12.4 | Plasma protein-based signature predicts distant metastasis and inductionchemotherapy benefit in Nasopharyngeal Carcinoma |
| 2020 | Molecular Therapy | 12.4 | HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis |
| 2020 | Acta Pharmaceutica Sinica B | 14.5 | Chrysin serves as a novel inhibitor of DGKa/FAK interaction to suppress the malignancy of esophageal squamous cellcarcinoma (ESCC) |
| 2020 | Journal of Extracellular Vesicles | 16 | Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innatelymphoid cell-dominant allergic airway inflammation through delivery ofmiR-146a-5p |
| 2020 | Nature Communications | 16.6 | Distinct effects of generalanesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models |
| 2020 | Molecular Cell | 16.6 | Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment |
| 2020 | Immunity | 32.4 | Excessive polyamine generation in keratinocytes promotes self-RNA sensing by dendritic cells in psoriasis |
| 2021 | Pharmacological Research | 9.3 | Affiliated Hospital of Integrated Traditional Chinese and WesternMedicine, Nanjing University of Chinese Medicine |
| 2021 | Theranostics | 12.4 | Intravenous transplantationof olfactory ensheathing cells reduces neuroinflammation after spinal cordinjury via interleukin-1 receptor antagonist |
| 2021 | Theranostics | 12.4 | Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer |
| 2021 | Hepatology | 13.5 | Group-2 Innate LymphoidCells Promote Hepatocellular Carcinoma Progression via CXCL2-Neutrophil Induced Immunosuppression |
| 2021 | Nature Cell Biology | 21.3 | m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype |
| 2021 | Signal Transduction and Targeted Therapy | 39.3 | Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer |
| 2021 | Cancer Cell | 50.3 | Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms |
| 2022 | Journal for ImmunoTherapy of Cancer | 10.9 | Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade |
| 2022 | PNAS | 11.1 | Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients |
| 2022 | Advanced Science | 15.1 | Mouse Modeling Dissecting Macrophage–BreastCancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment andBreast Tumorigenesis |
| 2022 | Nature Microbiology | 28.3 | Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions |
| 2023 | Nature Metabolism | 20.8 | TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis |
| 2023 | Journal of Hematology & Oncology | 28.5 | LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia |
| 2023 | Cancer cell | 50.3 | Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling |
【泪部资料】蛋白芯片案例集锦 | 肿瘤/癌症专题（一）科研重器15篇
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