上海，纽约——2020年7月28日，维亚生物科技控股集团（1873.HK）（以下简称“维亚生物”）与Schrödinger, Inc（Nasdaq: SDGR）（以下简称“Schrödinger”）宣布就早期新药研发建立战略合作伙伴关系。双方将整合各自在新药研发领域的优势资源，围绕基于结构的药物发现研究高潜力靶点的全新晶体结构，以推动首创（First-in-class）候选化合物的研发。
本次合作基于维亚生物晶体结构解析、表达方面的技术优势，结合Schrödinger在识别药物靶点及计算化学领域的丰富经验，共同研究过去未被攻克的靶点结构。Schrödinger将为维亚生物提供高成药潜力的靶点，这些靶点目前尚未有公开的晶体结构信息。基于Schrödinger提供的靶点信息，维亚生物将通过X射线晶体学解析出高分辨率的晶体结构信息。Schrödinger将依据解析后的晶体结构信息，结合其业界领先的计算平台以评估靶点的化学空间，并根据评估结果判断是否作为其内部管线产品进一步开发。
针对本次合作，维亚生物首席科学官叶志雄博士表示：“维亚生物与Schrödinger作为基于结构的药物发现领域的领军企业，本次的战略合作可谓是强强联手。Schrödinger拥有世界顶尖的计算化学平台，使得其在化学空间方面的具有高效且强大的科研能力，结合维亚生物在晶体结构领域的优势，我们将协力攻克过去未被解析的靶点，并基于此研发出造福于全球患者的首创疗法。”
Schrödinger执行副总裁，首席生物医学科学家兼研发总负责人Karen Akinsanya博士表示：“本次合作令人振奋，我们已经辨别发现了很多有潜力的靶点，但因为缺乏高分辨率的结构信息而无法进一步推进。维亚生物具备全球顶尖的X射线晶体学技术，我们坚信维亚生物解析的高质量靶点结构将完善我们基于物理作用的计算化学预测模型。我们期盼本次合作可以孕育出首创的候选化合物，并有望进一步推进到临床试验，以应对当下未被满足的医学需求。”
关于 Schrödinger
成立于1990年，Schrödinger拥有业界领先的计算平台用以加速药物研发和材料研发。我们服务于全球领先的生物制药公司、工业公司、学术机构及政府实验室。Schrödinger通过其计算平台与生物制药企业及生物技术公司联合研发了一系列新药管线项目。此外，Schrödinger正在利用其平台推进一系列自主研发的药物管线项目。Schrödinger在基础研究的持续投入，稳定推动了其计算平台的建设与发展。目前Schrödinger拥有400余名雇员，分布于纽约总部及全球其他城市。
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SHANGHAI and NEWYORK – Jul 28, 2020 -- Viva Biotech Holdings (1873.HK) and Schrödinger, Inc. (Nasdaq: SDGR) today announced a strategic collaboration to expand the reach of structure-based drug discovery by generating de novo crystal structures of high-value targets.
Under the terms of the collaboration, Schrödinger will identify drug discovery targets for which there are currently no crystal structures in the public domain, including those that could lead to first-in-class therapeutic candidates for its internal pipeline. Viva Biotech will deploy X-ray crystallography designed to structurally enable these targets by generating high-resolution structures with bound ligands. Schrödinger will then leverage its advanced computational platform at scale to explore large portions of chemical space with the goal of designing novel therapeutic candidates for such targets.
“This collaboration brings together two leaders in the field of structure-based drug discovery,” said Zhixiong Ye, Ph.D., Chief Scientific Officer at Viva Biotech. “Our expertise in x-ray crystallography and in other key related areas enables us to generate de novo structures for previously unsolved targets. Schrödinger’s industry-leading platform enables broad and rapid exploration of chemical space. Together, we hope to create innovative therapeutics with the potential to benefit patients around the world.”
“This is an exciting collaboration. We have identified numerous promising targets that are challenging to drug in part because they lack high-resolution crystal structures. Viva Biotech is widely recognized as a world leader in x-ray crystallography, and we believe they will be able to generate high-quality structures that are amenable to our physics-based predictive modeling,” said Karen Akinsanya, Ph.D., Executive Vice President, Chief Biomedical Scientist and Head of Discovery R&D at Schrödinger. “We hope this collaboration will lead to the discovery of therapeutic candidates that can be advanced into human trials in areas with critical unmet medical needs.”
About Schrödinger
Schrödinger’s industry-leading computational platform to accelerate drug discovery and materials design is deployed by leading biopharmaceutical and industrial companies, academic institutions, and government laboratories worldwide. In addition to this global business, Schrödinger is also applying its computational platform to a robust pipeline of drug discovery programs in collaboration with pharmaceutical companies and has co-founded leading biotech companies. In addition, Schrödinger is using its platform to advance a pipeline of internal, wholly-owned drug discovery programs. Schrödinger’s significant and ongoing investment in basic research continues to drive advances in its computational platform. Founded in 1990, Schrödinger has over 400 employees in its New York City headquarters and around the world.
Visit www.schrodinger.com for more information.
