Dec. 2021
热门新产品
CTLA-4 (E2V1Z) Rabbit mAb #53560
| 货号 | 规格 | 2021 年目录价 |
| 53560T |
20 µl | ￥1,400.00 |
| 53560S | 100 µl | ￥3,850.00 |
CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893
| 货号 | 规格 | 2021 年目录价 |
| 26893SF |
100 µg | ￥7,400.00 |
细胞毒性 T 淋巴细胞蛋白 4 (CTLA-4, CD152) 是 Ig 超家族的一员，能够负向调控 T 细胞的早期激活 (1-4)。CTLA-4 蛋白主要在 T 细胞中表达，包括 CD8+ 细胞毒性 T 细胞、CD4+ 辅助 T 细胞和 CD4+/FoxP3+ 调节性 T 细胞（1,2）。CTLA-4 蛋白与 CD28 在细胞表面争相结合 B7.1 (CD80) 和 B7.2 (CD86)，导致 T 细胞活性下调 (5)。CTLA-4 下游 SHP-2 和 PP2A 的激活会减弱 TCR 信号转导 (6)。研究表明，CTLA4 敲除小鼠患有引起过早死亡的淋巴组织增殖性疾病，表明 CTLA-4 可负向调控 T 细胞 (7)。相应 CTLA4 基因突变与多种疾病有关，包括胰岛素依赖性糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻、系统性红斑狼疮和 V 型自身免疫性淋巴细胞增殖性综合征 (8,9)。其他研究表明，CTLA-4 阻滞是肿瘤免疫治疗的有效策略 (10-12)。
同时，无载体配方CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893 也可以满足包括质谱流式，成像质谱流式等各种需要特殊抗体偶联的需求，是助力研究人员深入了解肿瘤免疫以及肿瘤微环境并开展转化医学研究的不二选择。
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产品名称 |
实验应用 |
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Developmental Biology |
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IF-IC, F |
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10179S |
YAP/TAZ (D24E4) Rabbit mAb (Alexa Fluor® 647 Conjugate) |
F |
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Glucose / Energy Metabolism |
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Immunology and Inflammation |
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53560S |
CTLA-4 (E2V1Z) Rabbit mAb |
WB, IP, IHC-Bond, IHC-P |
H, M |
26893SF |
CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) |
WB, IHC |
H, M |
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89368S |
LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor® 488 Conjugate) |
IF-F, IF-IC |
M |
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73582C |
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Infectious Diseases |
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MAP Kinase Signaling |
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40737S |
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Metabolism |
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58662S |
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Motif Antibodies |
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46784S |
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56161C |
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ELISA |
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RTK |
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Translational Control |
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DIMT1 Antibody |
WB |
H, M, R, Mk |
Ubiquitin and Ubiquitin-like proteins |
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10% SDS Solution |
C&R |
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7005S |
Glycine Solution (10X) |
ChIP, C&R |
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参考文献：
1. Brunet, J.F. et al. (1988) Immunol Rev 103, 21-36.
2. Brunet, J.F. et al. (1987) Nature 328, 267-70.
3. Dariavach, P. et al. (1988) Eur J Immunol 18, 1901-5.
4. Linsley, P.S. (1995) J Exp Med 182, 289-92.
5. Collins, A.V. et al. (2002) Immunity 17, 201-10.
6. Rudd, C.E. et al. (2009) Immunol Rev 229, 12-26.
7. Waterhouse, P. et al. (1995) Science 270, 985-8.
8. Romo-Tena, J. et al. (2013) Autoimmun Rev 12, 1171-6.
9. Wang, J. et al. (2014) PLoS One 9, e85982.
10. Egen, J.G. et al. (2002) Nat Immunol 3, 611-8.
11. Hodi, F.S. et al. (2003) Proc Natl Acad Sci U S A 100, 4712-7.
12. Pardoll, D.M. (2012) Nat Rev Cancer 12, 252-64.
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